DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ase and Ascl1

DIOPT Version :9

Sequence 1:	NP_476694.1	Gene:	ase / 30985	FlyBaseID:	FBgn0000137	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_071779.1	Gene:	Ascl1 / 64186	RGDID:	71010	Length:	233	Species:	Rattus norvegicus

Alignment Length:	230	Identity:	78/230 - (33%)
Similarity:	102/230 - (44%)	Gaps:	52/230 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SAAASTTNTTPISSQRKRPLGESQKQNRHNQQNQQLSKTSVPAKKCKTNKKLAVERPPKAGTISH 137
            :|||:.......|:|      :.|:|....||..|||..:........:|..|  :..|....|.
  Rat    34 AAAAAAAAAAAQSAQ------QQQQQQAPQQQAPQLSPVADGQPSGGGHKSAA--KQVKRQRSSS 90

  Fly   138 PHKSQSDQSFGTPGRKGLPLPQ----AVARRNARERNRVKQVNNGFALLREKIPEEVSEAFEAQG 198
            |...:..:.....| .|..|||    ||||||.|||||||.||.|||.|||.:|         .|
  Rat    91 PELMRCKRRLNFSG-FGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVP---------NG 145

  Fly   199 AGRGASKKLSKVETLRMAVEYIRSLEKLL--------GFDFPPLNSQGNSSGSGDDSFMFIKDEF 255
            |   |:||:|||||||.||||||:|::||        .|....|:...:.:.|.|
  Rat   146 A---ANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSND---------- 197

  Fly   256 DCLDEHFDDSLSNYEMDEQQTVQQTLSEDMLNPPQ 290
              |:......:|:|..||.       |.|.|:|.:
  Rat   198 --LNSMAGSPVSSYSSDEG-------SYDPLSPEE 223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ase	NP_476694.1	HLH	<172..224	CDD:278439	29/51 (57%)
Ascl1	NP_071779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..95		14/63 (22%)
		HLH	131..173	CDD:197674	30/53 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352164
Domainoid	1	1.000	67	1.000	Domainoid score	I9554
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1131543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9108
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13935
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.900