DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ase and LYL1

DIOPT Version :9

Sequence 1:	NP_476694.1	Gene:	ase / 30985	FlyBaseID:	FBgn0000137	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_005574.2	Gene:	LYL1 / 4066	HGNCID:	6734	Length:	280	Species:	Homo sapiens

Alignment Length:	254	Identity:	61/254 - (24%)
Similarity:	83/254 - (32%)	Gaps:	95/254 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAALSFSPSPPPKENPKENPNPGIKTTLKPFGKITVHNVLSESGANALQQHIANQNTIIRKIRDF 65
            :.|.|.:|:||||   ..:|.|                                     .::.:.
Human    21 VCAPSPAPAPPPK---PASPGP-------------------------------------PQVEEV 45

  Fly    66 GMLGAVQSAAASTTNTTP----ISSQRKRPLGESQKQNRHNQQNQQLSKTSVPAKKCKTNKKLAV 126
            |..|     .:|.....|    ||....||.|.:       ....:|.....|..:..|    ..
Human    46 GHRG-----GSSPPRLPPGVPVISLGHSRPPGVA-------MPTTELGTLRPPLLQLST----LG 94

  Fly   127 ERPPKAGTISHPHKSQSDQSFGTPG---------RKGLP-----------LPQAVARR---NARE 168
            ..||......|||...:....|..|         .|..|           .||.||||   |:||
Human    95 TAPPTLALHYHPHPFLNSVYIGPAGPFSIFPSSRLKRRPSHCELDLAEGHQPQKVARRVFTNSRE 159

  Fly   169 RNRVKQVNNGFALLREKIPEEVSEAFEAQGAGRGASKKLSKVETLRMAVEYIRSLEKLL 227
            |.|.:.||..||.||:.:|....:            :||||.|.||:|::||..|.:||
Human   160 RWRQQNVNGAFAELRKLLPTHPPD------------RKLSKNEVLRLAMKYIGFLVRLL 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ase	NP_476694.1	HLH	<172..224	CDD:278439	17/51 (33%)
LYL1	NP_005574.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..60		13/83 (16%)
		HLH	156..208	CDD:197674	25/63 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..280
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810