DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ase and MESP2

DIOPT Version :9

Sequence 1:	NP_476694.1	Gene:	ase / 30985	FlyBaseID:	FBgn0000137	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001035047.1	Gene:	MESP2 / 145873	HGNCID:	29659	Length:	397	Species:	Homo sapiens

Alignment Length:	162	Identity:	41/162 - (25%)
Similarity:	59/162 - (36%)	Gaps:	56/162 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 ERPPKAGTISHPH------------------KSQSDQSFGTP--GRKGLPLPQ----------AV 161
            :.||....:.|.|                  .|.||.|...|  |.:|||.||          |.
Human     3 QSPPPQSLLGHDHWIFAQGWGWAGHWDSTSPASSSDSSGSCPCDGARGLPQPQPPSCSSRAAEAA 67

  Fly   162 A--------------RRNARERNRVKQVNNGFAL--LREKIPEEVSEAFEAQGAGRGASKKLSKV 210
            |              |::|.||.:::......||  ||..:|..::.          |.:.|:|:
Human    68 ATTPRRARTGPAGGQRQSASEREKLRMRTLARALHELRRFLPPSLAP----------AGQSLTKI 122

  Fly   211 ETLRMAVEYIRSLEKLLGFDFPPLNSQGNSSG 242
            ||||:|:.||..|..:||.....|..:....|
Human   123 ETLRLAIRYIGHLSAVLGLSEESLQCRRRQRG 154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ase	NP_476694.1	HLH	<172..224	CDD:278439	15/53 (28%)
MESP2	NP_001035047.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..92		17/63 (27%)
		HLH	82..135	CDD:278439	19/62 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..208		1/3 (33%)
		13 X 2 AA tandem repeats of G-Q	179..204
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..295
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..376
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900