DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgcl and APA1

DIOPT Version :9

Sequence 1:	NP_525030.1	Gene:	Pgcl / 30984	FlyBaseID:	FBgn0011822	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001322792.1	Gene:	APA1 / 837740	AraportID:	AT1G11910	Length:	517	Species:	Arabidopsis thaliana

Alignment Length:	510	Identity:	158/510 - (30%)
Similarity:	221/510 - (43%)	Gaps:	137/510 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRFQIKSLVFLAGLIV-------LVGEANSTLRRIPIQKSPNFKRSHKNIVAER-DFVQQKYNR 57
            |.:.:|.|......|||       ...|.|....|:.::|   .|...||.:|.| :..|:|..|
plant     9 MGKMKIYSRTVAVSLIVSFLLCFSAFAERNDGTFRVGLKK---LKLDSKNRLAARVESKQEKPLR 70

  Fly    58 QY---TANGYPMEHLSNYDNFQYYGNISIGTPGQDFLVQFDTGSSNLWVPGSSC-ISTACQDHQV 118
            .|   .:....:..|.||.:.||||.|:||||.|.|.|.|||||||||||.|.| .|.||..|..
plant    71 AYRLGDSGDADVVVLKNYLDAQYYGEIAIGTPPQKFTVVFDTGSSNLWVPSSKCYFSLACLLHPK 135

  Fly   119 FYKNKSSTYVANGTAFSITYGTGSVSGYLSVDCVGFAGLTIQSQTFGEVTTEQGTNFVDAYFDGI 183
            :..::||||..||.|.:|.||||:::|:.|.|.|....|.::.|.|.|.|.|.|..||.|.||||
plant   136 YKSSRSSTYEKNGKAAAIHYGTGAIAGFFSNDAVTVGDLVVKDQEFIEATKEPGITFVVAKFDGI 200

  Fly   184 LGMGFPSLAVDGVTPTFQNMMQQGLVQSPVFSFFLRDNGSVTFYGGELILGGSDPSLYSGSLTYV 248
            ||:||..::|....|.:.||::|||::.|||||:|..|.... .||||:.||.||:.:.|..|||
plant   201 LGLGFQEISVGKAAPVWYNMLKQGLIKEPVFSFWLNRNADEE-EGGELVFGGVDPNHFKGKHTYV 264

  Fly   249 NVVQAAYWKFQTDYIKVGSTS---ISTFAQAIADTGTSLIIAPQA-------------------- 290
            .|.|..||:|....:.:|...   ..:...||||:||||:..|..
plant   265 PVTQKGYWQFDMGDVLIGGAPTGFCESGCSAIADSGTSLLAGPTTIITMINHAIGAAGVVSQQCK 329

  Fly   291 ----QYDQ---------------ISQL----FN--------------------ANSEGLFECSS- 311
                ||.|               .||:    |:                    :|..|...||:
plant   330 TVVDQYGQTILDLLLSETQPKKICSQIGLCTFDGTRGVSMGIESVVDKENAKLSNGVGDAACSAC 394

  Fly   312 ---------------------------------------------TSYPDLIININGVDFKIPAK 331
                                                         ::.|.:.:.|.|..|.:..:
plant   395 EMAVVWIQSQLRQNMTQERILNYVNELCERLPSPMGESAVDCAQLSTMPTVSLTIGGKVFDLAPE 459

  Fly   332 YYIIEEED---------FCSLAIQSINQDFWIMGDVFLGRIYTEFDVGNQRLGFA 377
            .|:::..:         |.:|.:.......||:||||:|:.:|.||.||:::|||
plant   460 EYVLKVGEGPVAQCISGFIALDVAPPRGPLWILGDVFMGKYHTVFDFGNEQVGFA 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	pepsin_retropepsin_like	67..378	CDD:299705	139/433 (32%)
Pgcl	NP_525030.1	Asp	76..379	CDD:278455	136/424 (32%)
APA1	NP_001322792.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.890