Protein Alignment Pgcl and bace1

DIOPT Version :9

• Sequence 1: NP_525030.1
• Gene: Pgcl / 30984
• FlyBaseID: FBgn0011822
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_001072485.1
• Gene: bace1 / 779940
• XenbaseID: XB-GENE-5787150
• Length: 502
• Species: Xenopus tropicalis
• Alignment Length: 445
• Identity: 97/445 - (21%)
• Similarity: 170/445 - (38%)
• Gaps: 117/445 - (26%)

  Fly     9 LVFLAGLIVLVGEANSTLRRIPIQKSP--------NFKRS-HKNIVAERDFVQQKYNRQYTANGY 64
            ||.|...:.:.|:   ...::|::..|        ..||| .|.:..:.:|:..
 Frog    14 LVLLPCFLPVTGQ---VAIKLPLKNCPGTCSPMAYRAKRSAEKGMELDTNFLDM----------- 64

  Fly    65 PMEHLSNYDNFQYYGNISIGTPGQDFLVQFDTGSSNLWVPGSSCISTACQDH----QVFYKNKSS 125
             :::|.......||..:.:|||.|...:..||||||        .:.....|    :.:::..|.
 Frog    65 -IDNLRGKSGQGYYVEMRVGTPPQTLNILVDTGSSN--------FAVGAAPHPFLKRYYHRQHSR 120

  Fly   126 TYVANGTAFSITYGTGSVSGYLSVDCV------------GFAGLTIQSQTFGEVTTEQGTNFVDA 178
            ||........:.|..|...|.|..|.|            ..|.:|...:.|     ..|:|
 Frog   121 TYRDVRRGVYVPYTQGKWEGELGTDLVTIPHGPNVTVTANIAAITDSDKFF-----INGSN---- 176

  Fly   179 YFDGILGMGFPSLA--VDGVTPTFQNMMQQGLVQSPVFS-------FFLRDNGSVTFYGGELILG 234
             ::||||:.:..:|  .|.:.|.|.::::|..|.: :||       |...::.:....||.:::|
 Frog   177 -WEGILGLAYAEIARPDDTLEPFFDSLVKQTRVPN-IFSLQLCGTGFHFNESDTSASVGGSMVIG 239

  Fly   235 GSDPSLYSGSLTYVNVVQAAYWKFQTDYIKVGSTSIS------TFAQAIADTGTSLIIAPQAQYD 293
            |.|||||.||:.|..:.:..|::.....|::....:.      .:.::|.|:||:.:..|:..:|
 Frog   240 GIDPSLYIGSIWYTPIRKEWYYEVIIVKIEINGQDLHMDCKEYNYDKSIVDSGTTNLRLPKRVFD 304

  Fly   294 QISQLFNANSEGLFECSSTSYPD---------------------------LIININGVDFKI--- 328
            ...:...|.|      |:..:||                           |:..:....|||
 Frog   305 AAVKSIKAAS------STEKFPDGFWLGEQLVCWQEGTTPWHIFPVISLYLMGEVANQSFKITIL 363

  Fly   329 ------PAKYYIIEEEDFCSLAIQSINQDFWIMGDVFLGRIYTEFDVGNQRLGFA 377
                  |.:.....:||....|: |.:....:||.|.:...|..||..|:|:|||
 Frog   364 PQQYLRPVEDIATAQEDCYKFAV-SQSTTGTVMGAVIMEGFYVVFDRANKRIGFA 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	pepsin_retropepsin_like	67..378	CDD:299705	86/378 (23%)
		Asp	76..379	CDD:278455	85/369 (23%)
bace1	NP_001072485.1	beta_secretase_like	73..438	CDD:133140	85/371 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910