Protein Alignment Pgcl and PGA3

DIOPT Version :10

• Sequence 1: NP_525030.1
• Gene: Pgcl / 30984
• FlyBaseID: FBgn0011822
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_001073275.1
• Gene: PGA3 / 643834
• HGNCID: 8885
• Length: 388
• Species: Homo sapiens
• Alignment Length: 398
• Identity: 155/398 - (38%)
• Similarity: 219/398 - (55%)
• Gaps: 42/398 - (10%)

  Fly    10 VFLAGLIVLVGEANSTLRRIPIQKSPNFKRSHKNIVAER----DFVQ-------QKYNRQYTA-- 61
            :.|.||:.|   :...:.::|:.:    |:|.:..::||    ||::       :||..|:.|
Human     4 LLLLGLVAL---SECIMYKVPLIR----KKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPT 61

  Fly    62 --NGYPMEHLSNYDNFQYYGNISIGTPGQDFLVQFDTGSSNLWVPGSSCISTACQDHQVFYKNKS 124
              :..|:|   ||.:.:|:|.|.||||.|||.|.|||||||||||...|.|.||.:|..|....|
Human    62 LVDEQPLE---NYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDS 123

  Fly   125 STYVANGTAFSITYGTGSVSGYLSVDCVGFAGLTIQSQTFGEVTTEQGTNFVDAYFDGILGMGFP 189
            |||.:.....||||||||::|.|..|.|...|::..:|.||...||.|:....|.||||||:.:|
Human   124 STYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYP 188

  Fly   190 SLAVDGVTPTFQNMMQQGLVQSPVFSFFL-RDNGSVTFYGGELILGGSDPSLYSGSLTYVNVVQA 253
            |::..|.||.|.|:..||||...:||.:| .|:.|    |..:|.||.|.|.|:|||.:|.|...
Human   189 SISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQS----GSVVIFGGIDSSYYTGSLNWVPVTVE 249

  Fly   254 AYWKFQTDYIKVGSTSISTF--AQAIADTGTSLIIAPQAQYDQISQLFNA--NSEG--LFECSS- 311
            .||:...|.|.:...:|:..  .|||.||||||:..|.:....|.....|  ||:|  :..||:
Human   250 GYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAI 314

  Fly   312 TSYPDLIININGVDFKIPAKYYIIEEEDFCSLAIQSIN-----QDFWIMGDVFLGRIYTEFDVGN 371
            :|.||::..||||.:.:|...||::.|..|....|.:|     .:.||:||||:.:.:|.||..|
Human   315 SSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRAN 379

  Fly   372 QRLGFAPV 379
            .::|.|||
Human   380 NQVGLAPV 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	Asp	76..379	CDD:394983	134/315 (43%)
PGA3	NP_001073275.1	A1_Propeptide	19..45	CDD:462326	7/29 (24%)
		pepsin_A	66..386	CDD:133145	137/326 (42%)