Protein Alignment Pgcl and PGC

DIOPT Version :9

• Sequence 1: NP_525030.1
• Gene: Pgcl / 30984
• FlyBaseID: FBgn0011822
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_002621.1
• Gene: PGC / 5225
• HGNCID: 8890
• Length: 388
• Species: Homo sapiens
• Alignment Length: 379
• Identity: 146/379 - (38%)
• Similarity: 206/379 - (54%)
• Gaps: 42/379 - (11%)

  Fly    28 RIPIQKSPNFKRSHKNIVAERDFVQ-QKYNRQYTANGYPMEHLS------NYDNFQYYGNISIGT 85
            ::|::|..:.:.:.|......:|:: .||:..:.   |....||      .|.:..|:|.|||||
Human    20 KVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWK---YRFGDLSVTYEPMAYMDAAYFGEISIGT 81

  Fly    86 PGQDFLVQFDTGSSNLWVPGSSCISTACQDHQVFYKNKSSTYVANGTAFSITYGTGSVSGYLSVD 150
            |.|:|||.|||||||||||...|.|.||..|..|..::||||..||..||:.||:||::|:...|
Human    82 PPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYD 146

  Fly   151 CVGFAGLTIQSQTFGEVTTEQGTNFVDAYFDGILGMGFPSLAVDGVTPTFQNMMQQGLVQSPVFS 215
            .:....:.:.:|.||....|.|||||.|.||||:|:.:|:|:||..|...|.|:|:|.:.|||||
Human   147 TLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFS 211

  Fly   216 FFL-RDNGSVTFYGGELILGGSDPSLYSGSLTYVNVVQAAYWKFQTDYIKVGSTS---ISTFAQA 276
            .:| ...||   .||.::.||.|.|||:|.:.:..|.|..||:...:...:|..:   .|...||
Human   212 VYLSNQQGS---SGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQA 273

  Fly   277 IADTGTSLIIAPQ-----------AQYDQISQ-LFNANSEGLFECSSTSYPDLIININGVDFKIP 329
            |.||||||:..||           ||.|:..| |.|.|       |..:.|.|...||||:|.:|
Human   274 IVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCN-------SIQNLPSLTFIINGVEFPLP 331

  Fly   330 AKYYIIEEEDFCSLAIQSI------NQDFWIMGDVFLGRIYTEFDVGNQRLGFA 377
            ...||:....:|::.::..      .|..||:|||||...|:.:|:||.|:|||
Human   332 PSSYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFA 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	pepsin_retropepsin_like	67..378	CDD:299705	139/339 (41%)
		Asp	76..379	CDD:278455	136/324 (42%)
PGC	NP_002621.1	A1_Propeptide	18..46	CDD:285240	4/25 (16%)
		gastricsin	70..387	CDD:133144	136/326 (42%)
		Asp	72..387	CDD:278455	136/324 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I1463
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2536
Isobase	1	0.950	-	0	Normalized mean entropy	S1195
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1456
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.830