Protein Alignment Pgcl and PGA5

DIOPT Version :9

• Sequence 1: NP_525030.1
• Gene: Pgcl / 30984
• FlyBaseID: FBgn0011822
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_055039.1
• Gene: PGA5 / 5222
• HGNCID: 8887
• Length: 388
• Species: Homo sapiens
• Alignment Length: 398
• Identity: 155/398 - (38%)
• Similarity: 219/398 - (55%)
• Gaps: 42/398 - (10%)

  Fly    10 VFLAGLIVLVGEANSTLRRIPIQKSPNFKRSHKNIVAER----DFVQ-------QKYNRQYTA-- 61
            :.|.||:.|   :...:.::|:.:    |:|.:..::||    ||::       :||..|:.|
Human     4 LLLLGLVAL---SECIMYKVPLIR----KKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPT 61

  Fly    62 --NGYPMEHLSNYDNFQYYGNISIGTPGQDFLVQFDTGSSNLWVPGSSCISTACQDHQVFYKNKS 124
              :..|:|   ||.:.:|:|.|.||||.|||.|.|||||||||||...|.|.||.:|..|....|
Human    62 LVDEQPLE---NYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDS 123

  Fly   125 STYVANGTAFSITYGTGSVSGYLSVDCVGFAGLTIQSQTFGEVTTEQGTNFVDAYFDGILGMGFP 189
            |||.:.....||||||||::|.|..|.|...|::..:|.||...||.|:....|.||||||:.:|
Human   124 STYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYP 188

  Fly   190 SLAVDGVTPTFQNMMQQGLVQSPVFSFFL-RDNGSVTFYGGELILGGSDPSLYSGSLTYVNVVQA 253
            |::..|.||.|.|:..||||...:||.:| .|:.|    |..:|.||.|.|.|:|||.:|.|...
Human   189 SISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKS----GSVVIFGGIDSSYYTGSLNWVPVTVE 249

  Fly   254 AYWKFQTDYIKVGSTSISTF--AQAIADTGTSLIIAPQAQYDQISQLFNA--NSEG--LFECSS- 311
            .||:...|.|.:...:|:..  .|||.||||||:..|.:....|.....|  ||:|  :..||:
Human   250 GYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAI 314

  Fly   312 TSYPDLIININGVDFKIPAKYYIIEEEDFCSLAIQSIN-----QDFWIMGDVFLGRIYTEFDVGN 371
            :|.||::..||||.:.:|...||::.|..|....|.:|     .:.||:||||:.:.:|.||..|
Human   315 SSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNVPTESGELWILGDVFIRQYFTVFDRAN 379

  Fly   372 QRLGFAPV 379
            .::|.|||
Human   380 NQVGLAPV 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	pepsin_retropepsin_like	67..378	CDD:299705	136/323 (42%)
		Asp	76..379	CDD:278455	134/315 (43%)
PGA5	NP_055039.1	A1_Propeptide	17..45	CDD:285240	7/31 (23%)
		pepsin_A	66..386	CDD:133145	137/326 (42%)
		Asp	75..387	CDD:278455	134/315 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I1463
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2536
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1456
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.980