Protein Alignment Pgcl and bace2

DIOPT Version :9

• Sequence 1: NP_525030.1
• Gene: Pgcl / 30984
• FlyBaseID: FBgn0011822
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: XP_009289748.1
• Gene: bace2 / 449818
• ZFINID: ZDB-GENE-041010-68
• Length: 503
• Species: Danio rerio
• Alignment Length: 478
• Identity: 119/478 - (24%)
• Similarity: 197/478 - (41%)
• Gaps: 111/478 - (23%)

  Fly    10 VFLAGLIVLVGEANST----LRRIPIQKSPNFKRSHKNIVAER----DFVQQKYNRQYTANGYPM 66
            ||...|.:..|:.|::    ||  |:||:....:|..::.::.    :|:..            :
Zfish    19 VFKIPLNIFAGKFNASVQLDLR--PLQKNEAAAKSGLSLASDPAGIVNFLDM------------I 69

  Fly    67 EHLSNYDNFQYYGNISIGTPGQDFLVQFDTGSSNLWVPGSSCISTACQDHQVFYKNK--SSTYVA 129
            .:|.......||..:.||||||...:..||||||.      .::.|...:...|.|:  ||||.:
Zfish    70 NNLKGDSGRGYYMQMIIGTPGQTLNILVDTGSSNF------AVAAAAHPYITHYFNRALSSTYQS 128

  Fly   130 NGTAFSITYGTGSVSGYLSVDCVGFAGLTIQSQTFGEVT-------TEQGTNFVDAYFDGILGMG 187
            ...|.::.|..|...|.|..|.:     ||.....|.:|       |.:|.......:.||||:.
Zfish   129 TERAVAVKYTQGEWEGELGTDLI-----TIPEGPSGAITINIAAILTSEGFFLPGINWQGILGLA 188

  Fly   188 FPSLA--VDGVTPTFQNMMQQGLVQSPVFSFFLRDNG---SVTF--YGGELILGGSDPSLYSGSL 245
            :|.||  ...|.|.|.::::|..:.. |||..:...|   |.|.  .||.||:||.:|:|:.|.:
Zfish   189 YPLLARPDPSVEPFFNSVVRQTGIPD-VFSLQMCGAGVPASTTGDPAGGSLIMGGVEPTLHRGPI 252

  Fly   246 TYVNVVQAAYWKFQTDYIKVGSTSIS------TFAQAIADTGTSLIIAP----QAQYDQISQ--L 298
            .|..|::..|::.:...::||..:::      ...:||.|:||:|:..|    .|..|.|.|  |
Zfish   253 WYTPVLEEWYYQVEVLKLEVGDQNLNLDCKEYNSDKAIVDSGTTLLRLPANVFTAVVDTIMQTSL 317

  Fly   299 FNANSEGLFECSSTS-----------YPDLIININGVD----FKIP--AKYYIIEEEDF-----C 341
            .:..|.|.|:.:..:           :|.:.|.:.|.:    |:|.  .:.||....|.     |
Zfish   318 IDDFSAGFFDGTKLACWMRGESPWRFFPKVSIYLRGTNTSQSFRITILPQLYIQPVTDIDGTLDC 382

  Fly   342 SLAIQSINQDFWIMGDVFLGRIYTEFDVGNQRLGFA--------------------------PVN 380
            .....|.:.:..::|...:...|..||...:|:|||                          ...
Zfish   383 FRFGISPSANGLVIGATVMEGFYVIFDRAQKRVGFAVSTCAENGGVPFAEIAGPFLAEGVASDCT 447

  Fly   381 SAVGLRKAVLWRI-FTLLLACGM 402
            |.:.||:.|:|.| :||:..|.:
Zfish   448 SGMTLREPVMWVIAYTLMGVCAV 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	pepsin_retropepsin_like	67..378	CDD:299705	98/386 (25%)
		Asp	76..379	CDD:278455	97/378 (26%)
bace2	XP_009289748.1	beta_secretase_like	77..439	CDD:133140	97/373 (26%)
		Asp	80..418	CDD:278455	95/349 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810