DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgcl and CG31926

DIOPT Version :9

Sequence 1:	NP_525030.1	Gene:	Pgcl / 30984	FlyBaseID:	FBgn0011822	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001259870.1	Gene:	CG31926 / 326174	FlyBaseID:	FBgn0051926	Length:	410	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	148/396 - (37%)
Similarity:	207/396 - (52%)	Gaps:	26/396 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LVFLAGLIVLVGEANSTLR-RIPIQKSP-----NFKRSHKNIVAER----DFVQQKYNRQYTANG 63
            |.:|..|.||..||.:..| ||.:.|:|     |.|...|.:..:.    |..:.|........|
  Fly    12 LFWLTVLAVLAFEAEARKRVRIGLHKNPEPIEENIKNELKTLSIKHNLNVDDTKAKTKTDTKVPG 76

  Fly    64 YPMEHLSNYDNFQYYGNISIGTPGQDFLVQFDTGSSNLWVPGSSCISTA--CQDHQVFYKNKSST 126
            ..:..|.|..|.:||..:..|.|.||..|..||||:||||..|.|..:.  |.:...:..:.|:|
  Fly    77 SKVATLENLYNTEYYTTLGFGNPPQDLKVLIDTGSANLWVLSSKCPDSVAPCANRIKYNSSASTT 141

  Fly   127 YVANGTAFSITYGTGS------VSGYLSVDCVGFAGLTIQSQTFGEVTTEQGTNFVDAYFDGILG 185
            |.|..|||:|.||:.|      :||:.|.|.|.|||.:|::|.|.|:|....|.|:.:..|||||
  Fly   142 YRAINTAFNIAYGSNSEEGPIALSGFQSQDTVNFAGYSIKNQIFAEITNAPETAFLKSQLDGILG 206

  Fly   186 MGFPSLAVDGVTPTFQNMMQQGLVQSPVFSFFLRDNGSVTFYGGELILGGSDPSLYSGSLTYVNV 250
            :||.|:|::.:||.|.|:|.||||...|||.:|..||:....||||||||||..||||.||||.|
  Fly   207 LGFASIAINSITPPFYNLMAQGLVNRSVFSIYLNRNGTNAINGGELILGGSDSGLYSGCLTYVPV 271

  Fly   251 VQAAYWKFQTDYIKVGSTSISTFAQAIADTGTSLIIAPQAQYDQISQLFN----ANSEGLF--EC 309
            ..|.||:|......:.........:||.|.|||||:.|:...|.|:|:..    ..|.|:|  :|
  Fly   272 SSAGYWQFTMTSANLNGFQFCENCEAILDVGTSLIVVPEQVLDTINQILGVLNPTASNGVFLVDC 336

  Fly   310 SST-SYPDLIININGVDFKIPAKYYIIEEEDFCSLAIQSIN-QDFWIMGDVFLGRIYTEFDVGNQ 372
            ||. ..||::..:....|.:.:..|::...:.|.....|:| ....|:|::|||..||.:|:..:
  Fly   337 SSIGDLPDIVFTVARRKFPLKSSDYVLRYGNTCVSGFTSMNGNSLLILGEIFLGAYYTTYDIVYK 401

  Fly   373 RLGFAP 378
            .:|.||
  Fly   402 LIGLAP 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	pepsin_retropepsin_like	67..378	CDD:299705	128/326 (39%)
Pgcl	NP_525030.1	Asp	76..379	CDD:278455	127/319 (40%)
CG31926	NP_001259870.1	pepsin_retropepsin_like	82..406	CDD:299705	128/323 (40%)
CG31926	NP_001259870.1	Asp	89..408	CDD:278455	127/319 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439956
Domainoid	1	1.000	97	1.000	Domainoid score	I1884
eggNOG	1	0.900	-	-		E1_KOG1339
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I1684
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D356089at33208
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.910