Protein Alignment Pgcl and Bace1

DIOPT Version :9

• Sequence 1: NP_525030.1
• Gene: Pgcl / 30984
• FlyBaseID: FBgn0011822
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_062077.1
• Gene: Bace1 / 29392
• RGDID: 2191
• Length: 501
• Species: Rattus norvegicus
• Alignment Length: 368
• Identity: 86/368 - (23%)
• Similarity: 154/368 - (41%)
• Gaps: 79/368 - (21%)

  Fly    73 DNFQ------YYGNISIGTPGQDFLVQFDTGSSNLWVPGSSCISTACQD--HQVFYKNKSSTYVA 129
            ||.:      ||..:::|:|.|...:..||||||.      .:..|...  |:.:.:..||||..
  Rat    65 DNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF------AVGAAPHPFLHRYYQRQLSSTYRD 123

  Fly   130 NGTAFSITYGTGSVSGYLSVDCVGF---AGLTIQSQTFGEVTTEQGTNFVD-AYFDGILGMGFPS 190
            ...:..:.|..|...|.|..|.|..   ..:|:::..  ...||....|:: :.::||||:.:..
  Rat   124 LRKSVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANI--AAITESDKFFINGSNWEGILGLAYAE 186

  Fly   191 LA--VDGVTPTFQNMMQQGLVQSPVFS-------FFLRDNGSVTFYGGELILGGSDPSLYSGSLT 246
            :|  .|.:.|.|.::::|..:.: :||       |.|....::...||.:|:||.|.|||:|||.
  Rat   187 IARPDDSLEPFFDSLVKQTHIPN-IFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLW 250

  Fly   247 YVNVVQAAYWKFQTDYIKVGSTSIS------TFAQAIADTGTSLIIAPQAQYDQISQLFNANSEG 305
            |..:.:..|::.....:::....:.      .:.::|.|:||:.:..|:       ::|.|..:.
  Rat   251 YTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPK-------KVFEAAVKS 308

  Fly   306 LFECSST-SYPD---------------------------LIININGVDFKI---PAKYY-----I 334
            :...||| .:||                           |:..:....|:|   |.:|.     :
  Rat   309 IKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDV 373

  Fly   335 IEEEDFCSLAIQSINQDFWIMGDVFLGRIYTEFDVGNQRLGFA 377
            ...:|.|.....|.:....:||.|.:...|..||...:|:|||
  Rat   374 ATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	pepsin_retropepsin_like	67..378	CDD:299705	86/368 (23%)
		Asp	76..379	CDD:278455	84/365 (23%)
Bace1	NP_062077.1	beta_secretase_like	72..437	CDD:133140	84/361 (23%)
		Interaction with RTN3. /evidence=ECO:0000250	479..501
		DXXLL. /evidence=ECO:0000250|UniProtKB:P56817	496..500

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810