Protein Alignment Pgcl and BACE2

DIOPT Version :9

• Sequence 1: NP_525030.1
• Gene: Pgcl / 30984
• FlyBaseID: FBgn0011822
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_036237.2
• Gene: BACE2 / 25825
• HGNCID: 934
• Length: 518
• Species: Homo sapiens
• Alignment Length: 420
• Identity: 107/420 - (25%)
• Similarity: 175/420 - (41%)
• Gaps: 104/420 - (24%)

  Fly    69 LSNYDNFQ------YYGNISIGTPGQDFLVQFDTGSSNLWVPGS--SCISTACQDHQVFYKNKSS 125
            |:..||.|      ||..:.||||.|...:..||||||..|.|:  |.|.|      .|...:||
Human    78 LAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDT------YFDTERSS 136

  Fly   126 TYVANGTAFSITYGTGSVSGYLSVDCV----GFAGLTIQSQTFGEVTTEQGTNFV--DAYFDGIL 184
            ||.:.|...::.|..||.:|::..|.|    ||.    .|......|..:..||.  ...::|||
Human   137 TYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFN----TSFLVNIATIFESENFFLPGIKWNGIL 197

  Fly   185 GMGFPSLA--VDGVTPTFQNMMQQGLVQSPVFSF-----FLRDNGSVTFYGGELILGGSDPSLYS 242
            |:.:.:||  ...:...|.:::.|..:.: |||.     .|...||.| .||.|:|||.:||||.
Human   198 GLAYATLAKPSSSLETFFDSLVTQANIPN-VFSMQMCGAGLPVAGSGT-NGGSLVLGGIEPSLYK 260

  Fly   243 GSLTYVNVVQAAYWKFQTDYIKVGSTSIS------TFAQAIADTGTSLIIAPQAQYDQI------ 295
            |.:.|..:.:..|::.:...:::|..|::      ...:||.|:||:|:..||..:|.:
Human   261 GDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVAR 325

  Fly   296 SQLFNANSEGLF-----ECSSTS------YPDLIININGVDFKIPAKYYIIEEEDFCSLAIQ--- 346
            :.|....|:|.:     .|.:.|      :|.:.|.:...:.....:..|:.:     |.||
Human   326 ASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQ-----LYIQPMM 385

  Fly   347 --SINQDFW-----------IMGDVFLGRIYTEFDVGNQRLGFA-----------------PVNS 381
              .:|.:.:           ::|...:...|..||...:|:|||                 |.::
Human   386 GAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFST 450

  Fly   382 ---------AVGLRKAVLWRI-FTLLLACG 401
                     |..|.:.:||.: :.|:..||
Human   451 EDVASNCVPAQSLSEPILWIVSYALMSVCG 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	pepsin_retropepsin_like	67..378	CDD:299705	99/385 (26%)
		Asp	76..379	CDD:278455	96/379 (25%)
BACE2	NP_036237.2	beta_secretase_like	89..450	CDD:133140	96/377 (25%)
		Asp	92..430	CDD:278455	94/354 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810