DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgcl and Cym

DIOPT Version :9

Sequence 1:	NP_525030.1	Gene:	Pgcl / 30984	FlyBaseID:	FBgn0011822	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001104613.1	Gene:	Cym / 229697	MGIID:	2684977	Length:	379	Species:	Mus musculus

Alignment Length:	388	Identity:	130/388 - (33%)
Similarity:	192/388 - (49%)	Gaps:	23/388 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRFQIKSLVFLAGLIVLVGEANSTLRRIPIQKSPNFKRSHKNIVAERDFV---QQKYNRQYTAN 62
            |.||    ::.||.|.:   ..:..:.|||:.|..:.:.:.|......||:   |.:::.:.:..
Mouse     1 MRRF----VLLLAALAI---SQSHVVTRIPLHKGKSLRNTLKEQGLLEDFLSRQQYEFSEKNSRI 58

  Fly    63 G-YPMEHLSNYDNFQYYGNISIGTPGQDFLVQFDTGSSNLWVPGSSCISTACQDHQVFYKNKSST 126
            | ...|.|.||.:.:|:|.|.||||.|:|.|.||||||.||||...|.|..|::|..|..:||.|
Mouse    59 GVVASEPLINYLDSEYFGTIYIGTPPQEFTVVFDTGSSELWVPSVYCNSKVCRNHHRFDPSKSIT 123

  Fly   127 YVANGTAFSITYGTGSVSGYLSVDCVGFAGLTIQSQTFGEVTTEQGTNFVDAYFDGILGMGFPSL 191
            :........:.||||.:.|:|:.|.|..:.:.:..||.|..|.|.|..|..:.||||||:.:|:.
Mouse   124 FQNLSKPLFVQYGTGRMEGFLAYDTVTVSDIVVSHQTVGLSTQEPGDIFTYSPFDGILGLAYPTF 188

  Fly   192 AVDGVTPTFQNMMQQGLVQSPVFSFFLRDNGSVTFYGGELILGGSDPSLYSGSLTYVNVVQAAYW 256
            |.....|.|.|||.:.||...:||.::..|..    |..|.||..|.|.:.|||.:|.|....||
Mouse   189 ASKYSVPIFDNMMNRHLVAQDLFSVYMSRNEQ----GSMLTLGAIDQSYFIGSLHWVPVTVQGYW 249

  Fly   257 KFQTDYIKVGSTSIST--FAQAIADTGTSLIIAPQAQYDQISQLFNA----NSEGLFECSSTS-Y 314
            :|..|.|.:....::.  ...|:.||||:|:..|......|.|:..|    |.:...:|.... .
Mouse   250 QFTVDRITINGEVVACQGGCPAVLDTGTALLTGPGRDILNIQQVIGAVQGHNDQFDIDCWRLDIM 314

  Fly   315 PDLIININGVDFKIPAKYYIIEEEDFCSLAIQSINQDFWIMGDVFLGRIYTEFDVGNQRLGFA 377
            |.::..|:|.:|.:|...|..:.:.|||...:. ....||:||||:...|:.||..|.|:|.|
Mouse   315 PTVVFEIHGREFPLPPYAYTNQVQGFCSSGFKQ-GSHMWILGDVFIREFYSVFDRANNRVGLA 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	pepsin_retropepsin_like	67..378	CDD:299705	115/318 (36%)
Pgcl	NP_525030.1	Asp	76..379	CDD:278455	111/309 (36%)
Cym	NP_001104613.1	A1_Propeptide	19..44	CDD:285240	6/24 (25%)
		pepsin_retropepsin_like	64..377	CDD:299705	115/318 (36%)
		Asp	73..378	CDD:278455	111/309 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930