Protein Alignment Pgcl and Ren2

DIOPT Version :10

• Sequence 1: NP_525030.1
• Gene: Pgcl / 30984
• FlyBaseID: FBgn0011822
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_112470.2
• Gene: Ren2 / 19702
• MGIID: 97899
• Length: 424
• Species: Mus musculus
• Alignment Length: 381
• Identity: 142/381 - (37%)
• Similarity: 213/381 - (55%)
• Gaps: 35/381 - (9%)

  Fly    24 STLRRIPIQKSPNFKRSHKNIVAERDFVQQKYNRQY---------TANGYPMEHLSNYDNFQYYG 79
            :|..|||::|.|    |.:.|:.||.....:.:.::         |....|:. |:||.|.||||
Mouse    49 TTFERIPLKKMP----SVREILEERGVDMTRLSAEWDVFTKRSSLTDLISPVV-LTNYLNSQYYG 108

  Fly    80 NISIGTPGQDFLVQFDTGSSNLWVPGSSC--ISTACQDHQVFYKNKSSTYVANGTAFSITYGTGS 142
            .|.||||.|.|.|.|||||:|||||.:.|  :..||..|.::..:.||:|:.||..|:|.||:|.
Mouse   109 EIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENGDDFTIHYGSGR 173

  Fly   143 VSGYLSVDCVGFAGLTIQSQTFGEVTTEQGTNFVDAYFDGILGMGFPSLAVDGVTPTFQNMMQQG 207
            |.|:||.|.|...|:|: :|||||||......|:.|.|||:||||||:.||.||||.|.:::.||
Mouse   174 VKGFLSQDSVTVGGITV-TQTFGEVTELPLIPFMLAQFDGVLGMGFPAQAVGGVTPVFDHILSQG 237

  Fly   208 LVQSPVFSFFLRDNGSVTFYGGELILGGSDPSLYSGSLTYVNVVQAAYWKFQTDYIKVGSTSI-- 270
            :::..|||.:.  |......|||::||||||..|.|...||::.:...|:.....:.|||:::
Mouse   238 VLKEKVFSVYY--NRGPHLLGGEVVLGGSDPEHYQGDFHYVSLSKTDSWQITMKGVSVGSSTLLC 300

  Fly   271 STFAQAIADTGTSLIIAPQAQYDQISQLFNANSEGLFE----CSST-SYPDLIININGVDFKIPA 330
            ....:.:.|||:|.|.||.:....|.|...|..:.|.|    ||.. :.||:..|:.|..:.:.:
Mouse   301 EEGCEVVVDTGSSFISAPTSSLKLIMQALGAKEKRLHEYVVSCSQVPTLPDISFNLGGRAYTLSS 365

  Fly   331 KYYIIE----EEDFCSLAIQSIN-----QDFWIMGDVFLGRIYTEFDVGNQRLGFA 377
            ..|:::    .:..|::|:.:::     ...|::|..|:.:.|||||..|.|:|||
Mouse   366 TDYVLQYPNRRDKLCTVALHAMDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFA 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	Asp	76..379	CDD:394983	126/320 (39%)
Ren2	NP_112470.2	A1_Propeptide	53..>71	CDD:462326	9/21 (43%)
		renin_like	98..423	CDD:133154	130/327 (40%)