Protein Alignment Pgcl and Ctsd

DIOPT Version :9

• Sequence 1: NP_525030.1
• Gene: Pgcl / 30984
• FlyBaseID: FBgn0011822
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_599161.2
• Gene: Ctsd / 171293
• RGDID: 621511
• Length: 407
• Species: Rattus norvegicus
• Alignment Length: 405
• Identity: 158/405 - (39%)
• Similarity: 224/405 - (55%)
• Gaps: 45/405 - (11%)

  Fly     9 LVFLAGLIVLVGEANSTLRRIPIQKSPNFKRSHKNIVAE-RDFVQQKYNRQYTANGYP------M 66
            |:.:.||:   ..::|.|.|||::|..:.:|:...:... .|.:.:....:|:....|      .
  Rat     7 LLLILGLL---AASSSALIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPRTKEPVS 68

  Fly    67 EHLSNYDNFQYYGNISIGTPGQDFLVQFDTGSSNLWVPGSSC--ISTACQDHQVFYKNKSSTYVA 129
            |.|.||.:.||||.|.||||.|.|.|.|||||||||||...|  :..||..|..:..:||||||.
  Rat    69 ELLKNYLDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWVHHKYNSDKSSTYVK 133

  Fly   130 NGTAFSITYGTGSVSGYLSVDCVG------FAGLTIQSQTFGEVTTEQGTNFVDAYFDGILGMGF 188
            |||:|.|.||:||:|||||.|.|.      ..|:.::.|.|||.|.:.|..|:.|.||||||||:
  Rat   134 NGTSFDIHYGSGSLSGYLSQDTVSVPCKSDLGGIKVEKQIFGEATKQPGVVFIAAKFDGILGMGY 198

  Fly   189 PSLAVDGVTPTFQNMMQQGLVQSPVFSFFL-RD-NGSVTFYGGELILGGSDPSLYSGSLTYVNVV 251
            |.::|:.|.|.|.|:|:|.||:..:|||:| || .|..   ||||:|||:|...|.|.|:|:||.
  Rat   199 PFISVNNVLPVFDNLMKQKLVEKNIFSFYLNRDPTGQP---GGELMLGGTDSRYYHGELSYLNVT 260

  Fly   252 QAAYWKFQTDYIKVGS--TSISTFAQAIADTGTSLIIAPQAQYDQISQLFNA-------NSEGLF 307
            :.|||:...|.::|||  |......:||.||||||::.|   .|::.:|..|       ..|.:.
  Rat   261 RKAYWQVHMDQLEVGSELTLCKGGCEAIVDTGTSLLVGP---VDEVKELQKAIGAVPLIQGEYMI 322

  Fly   308 ECSS-TSYPDLIININGVDFKIPAKYYIIEEED---------FCSLAIQSINQDFWIMGDVFLGR 362
            .|.. :|.|.:...:.|.::::..:.||::...         |..:.|...:...||:||||:|.
  Rat   323 PCEKVSSLPIITFKLGGQNYELHPEKYILKVSQAGKTICLSGFMGMDIPPPSGPLWILGDVFIGC 387

  Fly   363 IYTEFDVGNQRLGFA 377
            .||.||....|:|||
  Rat   388 YYTVFDREYNRVGFA 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	pepsin_retropepsin_like	67..378	CDD:299705	145/340 (43%)
		Asp	76..379	CDD:278455	141/331 (43%)
Ctsd	NP_599161.2	A1_Propeptide	21..46	CDD:285240	6/24 (25%)
		Cathepsin_D2	73..403	CDD:133157	143/336 (43%)
		Asp	78..404	CDD:278455	141/331 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930