DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pgcl and CTSE

DIOPT Version :9

Sequence 1:NP_525030.1 Gene:Pgcl / 30984 FlyBaseID:FBgn0011822 Length:407 Species:Drosophila melanogaster
Sequence 2:XP_011507546.1 Gene:CTSE / 1510 HGNCID:2530 Length:401 Species:Homo sapiens


Alignment Length:411 Identity:177/411 - (43%)
Similarity:237/411 - (57%) Gaps:51/411 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 IKSLVFLAGLIVLVGEANSTLRRIPIQKSPNFK-------------RSHKNIVAERDFVQQKYNR 57
            :|:|:.|..:::.:|||..:|.|:|:::.|:.|             :|| |:    |.:|  :..
Human     1 MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSH-NL----DMIQ--FTE 58

  Fly    58 QYTANGYPMEHLSNYDNFQYYGNISIGTPGQDFLVQFDTGSSNLWVPGSSCISTACQDHQVFYKN 122
            ..:.:....|.|.||.:.:|:|.||||:|.|:|.|.|||||||||||...|.|.||:.|..|..:
Human    59 SCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPS 123

  Fly   123 KSSTYVANGTAFSITYGTGSVSGYLSVDCVG-----FAGLTIQSQTFGEVTTEQGTNFVDAYFDG 182
            :||||...|.:|||.|||||:||.:..|.|.     ..|||:..|.|||..||.|..||||.|||
Human   124 QSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFSYQVEGLTVVGQQFGESVTEPGQTFVDAEFDG 188

  Fly   183 ILGMGFPSLAVDGVTPTFQNMMQQGLVQSPVFSFFLRDN--GSVTFYGGELILGGSDPSLYSGSL 245
            |||:|:|||||.||||.|.|||.|.||..|:||.::..|  |..   |.|||.||.|.|.:||||
Human   189 ILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGA---GSELIFGGYDHSHFSGSL 250

  Fly   246 TYVNVVQAAYWKFQTDYIKVGSTSI--STFAQAIADTGTSLIIAPQAQYDQISQLFNA------N 302
            .:|.|.:.|||:...|.|:||.|.:  |...|||.|||||||..|.   |:|.||.||      :
Human   251 NWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPS---DKIKQLQNAIGAAPVD 312

  Fly   303 SEGLFECSSTS-YPDLIININGVDFKI-PAKYYIIEEED---FCSLAIQSIN-----QDFWIMGD 357
            .|...||::.: .||:...||||.:.: |..|.:::..|   |||...|.::     ...||:||
Human   313 GEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGD 377

  Fly   358 VFLGRIYTEFDVGNQRLGFAP 378
            ||:.:.|:.||.||.|:|.||
Human   378 VFIRQFYSVFDRGNNRVGLAP 398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PgclNP_525030.1 pepsin_retropepsin_like 67..378 CDD:299705 159/335 (47%)
Asp 76..379 CDD:278455 157/328 (48%)
CTSEXP_011507546.1 A1_Propeptide 21..49 CDD:285240 5/27 (19%)
Asp 77..399 CDD:278455 157/328 (48%)
Cathespin_E 78..398 CDD:133153 155/325 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151486
Domainoid 1 1.000 297 1.000 Domainoid score I1463
eggNOG 1 0.900 - - E1_KOG1339
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 319 1.000 Inparanoid score I2536
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54317
OrthoDB 1 1.010 - - D1619495at2759
OrthoFinder 1 1.000 - - FOG0000066
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR47966
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.910

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