Protein Alignment Pgcl and CTSE

DIOPT Version :10

• Sequence 1: NP_525030.1
• Gene: Pgcl / 30984
• FlyBaseID: FBgn0011822
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: XP_011507546.1
• Gene: CTSE / 1510
• HGNCID: 2530
• Length: 401
• Species: Homo sapiens
• Alignment Length: 411
• Identity: 177/411 - (43%)
• Similarity: 237/411 - (57%)
• Gaps: 51/411 - (12%)

  Fly     6 IKSLVFLAGLIVLVGEANSTLRRIPIQKSPNFK-------------RSHKNIVAERDFVQQKYNR 57
            :|:|:.|..:::.:|||..:|.|:|:::.|:.|             :|| |:    |.:|  :..
Human     1 MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSH-NL----DMIQ--FTE 58

  Fly    58 QYTANGYPMEHLSNYDNFQYYGNISIGTPGQDFLVQFDTGSSNLWVPGSSCISTACQDHQVFYKN 122
            ..:.:....|.|.||.:.:|:|.||||:|.|:|.|.|||||||||||...|.|.||:.|..|..:
Human    59 SCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPS 123

  Fly   123 KSSTYVANGTAFSITYGTGSVSGYLSVDCVG-----FAGLTIQSQTFGEVTTEQGTNFVDAYFDG 182
            :||||...|.:|||.|||||:||.:..|.|.     ..|||:..|.|||..||.|..||||.|||
Human   124 QSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFSYQVEGLTVVGQQFGESVTEPGQTFVDAEFDG 188

  Fly   183 ILGMGFPSLAVDGVTPTFQNMMQQGLVQSPVFSFFLRDN--GSVTFYGGELILGGSDPSLYSGSL 245
            |||:|:|||||.||||.|.|||.|.||..|:||.::..|  |..   |.|||.||.|.|.:||||
Human   189 ILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGA---GSELIFGGYDHSHFSGSL 250

  Fly   246 TYVNVVQAAYWKFQTDYIKVGSTSI--STFAQAIADTGTSLIIAPQAQYDQISQLFNA------N 302
            .:|.|.:.|||:...|.|:||.|.:  |...|||.|||||||..|.   |:|.||.||      :
Human   251 NWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPS---DKIKQLQNAIGAAPVD 312

  Fly   303 SEGLFECSSTS-YPDLIININGVDFKI-PAKYYIIEEED---FCSLAIQSIN-----QDFWIMGD 357
            .|...||::.: .||:...||||.:.: |..|.:::..|   |||...|.::     ...||:||
Human   313 GEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGD 377

  Fly   358 VFLGRIYTEFDVGNQRLGFAP 378
            ||:.:.|:.||.||.|:|.||
Human   378 VFIRQFYSVFDRGNNRVGLAP 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	Asp	76..379	CDD:394983	157/328 (48%)
CTSE	XP_011507546.1	A1_Propeptide	23..49	CDD:462326	4/25 (16%)
		Cathespin_E	78..398	CDD:133153	155/325 (48%)