Protein Alignment Pgcl and CTSD

DIOPT Version :9

• Sequence 1: NP_525030.1
• Gene: Pgcl / 30984
• FlyBaseID: FBgn0011822
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_001900.1
• Gene: CTSD / 1509
• HGNCID: 2529
• Length: 412
• Species: Homo sapiens
• Alignment Length: 413
• Identity: 164/413 - (39%)
• Similarity: 224/413 - (54%)
• Gaps: 47/413 - (11%)

  Fly     5 QIKSLVFLAGLIVLVGEANSTLRRIPIQKSPNFKRSHKNIVAE-RDFVQQ----KYNRQYTA--N 62
            |..||:.||  :.|:....|.|.|||:.|..:.:|:...:... .|.:.:    ||::...|  .
Human     2 QPSSLLPLA--LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTE 64

  Fly    63 GYPMEHLSNYDNFQYYGNISIGTPGQDFLVQFDTGSSNLWVPGSSC--ISTACQDHQVFYKNKSS 125
            |...|.|.||.:.||||.|.||||.|.|.|.|||||||||||...|  :..||..|..:..:|||
Human    65 GPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSS 129

  Fly   126 TYVANGTAFSITYGTGSVSGYLSVDCV-----------GFAGLTIQSQTFGEVTTEQGTNFVDAY 179
            |||.|||:|.|.||:||:|||||.|.|           ...|:.::.|.|||.|.:.|..|:.|.
Human   130 TYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAK 194

  Fly   180 FDGILGMGFPSLAVDGVTPTFQNMMQQGLVQSPVFSFFL-RDNGSVTFYGGELILGGSDPSLYSG 243
            |||||||.:|.::|:.|.|.|.|:|||.||...:|||:| ||..:..  ||||:|||:|...|.|
Human   195 FDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQP--GGELMLGGTDSKYYKG 257

  Fly   244 SLTYVNVVQAAYWKFQTDYIKV--GSTSISTFAQAIADTGTSLIIAPQAQYDQISQLFNA----- 301
            ||:|:||.:.|||:...|.::|  |.|......:||.||||||::.|   .|::.:|..|
Human   258 SLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGP---VDEVRELQKAIGAVP 319

  Fly   302 --NSEGLFECSSTS-YPDLIININGVDFKIPAKYYIIEEED---------FCSLAIQSINQDFWI 354
              ..|.:..|...| .|.:.:.:.|..:|:..:.|.::...         |..:.|...:...||
Human   320 LIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWI 384

  Fly   355 MGDVFLGRIYTEFDVGNQRLGFA 377
            :||||:||.||.||..|.|:|||
Human   385 LGDVFIGRYYTVFDRDNNRVGFA 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	pepsin_retropepsin_like	67..378	CDD:299705	146/344 (42%)
		Asp	76..379	CDD:278455	142/335 (42%)
CTSD	NP_001900.1	A1_Propeptide	22..49	CDD:400357	6/26 (23%)
		Cathepsin_D2	73..408	CDD:133157	144/340 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.890