Protein Alignment Pgcl and bace2

DIOPT Version :9

• Sequence 1: NP_525030.1
• Gene: Pgcl / 30984
• FlyBaseID: FBgn0011822
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_001135590.1
• Gene: bace2 / 100216145
• XenbaseID: XB-GENE-1014090
• Length: 499
• Species: Xenopus tropicalis
• Alignment Length: 404
• Identity: 108/404 - (26%)
• Similarity: 171/404 - (42%)
• Gaps: 92/404 - (22%)

  Fly    77 YYGNISIGTPGQDFLVQFDTGSSNLWVPGSSCISTACQDHQVFYKNKSST-YVANGTAFSITYGT 140
            ||..:.||||.|...:..||||||..|.|:     ...|...|:.:|.|| |....|..::.|..
 Frog    75 YYLELLIGTPPQKMNILVDTGSSNFAVAGA-----LNPDITTFFDSKLSTSYEPLNTQVTVRYTQ 134

  Fly   141 GSVSGYLSVDCV----GFAGLTIQSQTF--GEVTTEQGTNFV--DAYFDGILGMGFPSLA--VDG 195
            ||.:|.|..|.:    |..|      ||  ...:..|..||.  :..:.||||:.:.:||  ...
 Frog   135 GSWTGLLGKDVISMPKGVNG------TFLINIASIFQSENFFLPNINWQGILGLAYSTLAKPSSS 193

  Fly   196 VTPTFQNMMQQGLVQSPVFSFFLRDNG----SVTFYGGELILGGSDPSLYSGSLTYVNVVQAAYW 256
            |.|.|.:::||..:.: :||..:...|    .:....|.|:|||.:||||.|.:.|..:.:.  |
 Frog   194 VEPFFDSLVQQENIPN-IFSMQMCGAGQPSPGIGINAGSLVLGGIEPSLYQGDIWYTPITEE--W 255

  Fly   257 KFQTDYIK--VGSTSIS------TFAQAIADTGTSLIIAPQAQYD-------QISQLFNANSE-- 304
            .:|.:.:|  ||..:::      ...:||.|:||:|:..|...::       |.|.:.|.|:|
 Frog   256 YYQVEVLKFEVGGQNLNLDCTVYNSDKAIVDSGTTLLRLPDKVFNAMVDAIVQTSLIQNFNAEFW 320

  Fly   305 -GL-FECSSTS------YPDLIININGVD----FKIPAK--YYI-----IEEEDFCSLAIQSINQ 350
             || ..|...:      :||:.|.:...:    |::..|  .||     .:|...|.....|.:.
 Frog   321 AGLQLACWDKTQDPWNYFPDISIYLRDTNSSRSFRLTLKPQLYIQSVLTFQESLNCFRFGISQSA 385

  Fly   351 DFWIMGDVFLGRIYTEFDVGNQRLGFA----------PVNSAVG----------------LRKAV 389
            ...::|...:...|..||...:|:|||          .|:...|                ||:.:
 Frog   386 SALVIGATVMEGFYVIFDRAEKRVGFAVSSCAEVSGITVSEIAGPFGTSDVSSNCIARNPLREPI 450

  Fly   390 LWRI-FTLLLACGM 402
            :|.| ::|:..|||
 Frog   451 MWIISYSLMSLCGM 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgcl	NP_525030.1	pepsin_retropepsin_like	67..378	CDD:299705	98/361 (27%)
		Asp	76..379	CDD:278455	98/362 (27%)
bace2	NP_001135590.1	beta_secretase_like	72..433	CDD:133140	100/371 (27%)
		Asp	75..412	CDD:278455	96/350 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910