DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(1)sc and TWIST1

DIOPT Version :10

Sequence 1:NP_476623.1 Gene:l(1)sc / 30983 FlyBaseID:FBgn0002561 Length:257 Species:Drosophila melanogaster
Sequence 2:NP_000465.1 Gene:TWIST1 / 7291 HGNCID:12428 Length:202 Species:Homo sapiens


Alignment Length:72 Identity:26/72 - (36%)
Similarity:33/72 - (45%) Gaps:16/72 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 NARERNRVKQVNNGFVNLRQHLPQTVVNSLSNGGRGSSKKLSKVDTLRIAVEYIRGL-----QDM 148
            |.|||.|.:.:|..|..||:.:|..           .|.||||:.||::|..||..|     .|.
Human   114 NVRERQRTQSLNEAFAALRKIIPTL-----------PSDKLSKIQTLKLAARYIDFLYQVLQSDE 167

  Fly   149 LDDGTAS 155
            ||...||
Human   168 LDSKMAS 174

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(1)scNP_476623.1 bHLH_TS_dAS-C_like 94..149 CDD:381587 18/59 (31%)
TWIST1NP_000465.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..105
bHLH_TS_TWIST1 98..174 CDD:381418 24/70 (34%)
Sufficient for transactivation activity. /evidence=ECO:0000250 161..191 5/14 (36%)
Blue background indicates that the domain is not in the aligned region.

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