DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)sc and TAL1

DIOPT Version :9

Sequence 1:	NP_476623.1	Gene:	l(1)sc / 30983	FlyBaseID:	FBgn0002561	Length:	257	Species:	Drosophila melanogaster
Sequence 2:	NP_001274276.1	Gene:	TAL1 / 6886	HGNCID:	11556	Length:	331	Species:	Homo sapiens

Alignment Length:	210	Identity:	51/210 - (24%)
Similarity:	77/210 - (36%)	Gaps:	50/210 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LIAPKIPLGTSQLQNMQQSQQS---------NVGPMLSSQKKKFNYNN------MPYGEQL---- 82
            |.||..| |.:.|.::.|...|         :..||       |..||      .||..::
Human   126 LAAPAAP-GRALLYSLSQPLASLGSGFFGEPDAFPM-------FTTNNRVKRRPSPYEMEITDGP 182

  Fly    83 -PSVARR---NARERNRVKQVNNGFVNLRQHLPQTVVNSLSNGGRGSSKKLSKVDTLRIAVEYIR 143
             ..|.||   |:|||.|.:.||..|..||:.:|.          ....|||||.:.||:|::||.
Human   183 HTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPT----------HPPDKKLSKNEILRLAMKYIN 237

  Fly   144 GLQDMLDDGTASSTRHIYNSADE---------SSNDGSSYNDYNDSLDSSQQFLTGATQSAQSHS 199
            .|..:|:|.....|:......|.         ....|:..:|....:.|.......:...|.|..
Human   238 FLAKLLNDQEEEGTQRAKTGKDPVVGAGGGGGGGGGGAPPDDLLQDVLSPNSSCGSSLDGAASPD 302

  Fly   200 YHSASPTPSYSGSEI 214
            .::..|.|.::...:
Human   303 SYTEEPAPKHTARSL 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)sc	NP_476623.1	HLH	<96..146	CDD:278439	16/49 (33%)
l(1)sc	NP_476623.1	Peptidase_C11	<128..218	CDD:304483	21/96 (22%)
TAL1	NP_001274276.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..86
		HLH	193..243	CDD:197674	22/59 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..331		9/69 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810