DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)sc and Ascl1

DIOPT Version :9

Sequence 1:	NP_476623.1	Gene:	l(1)sc / 30983	FlyBaseID:	FBgn0002561	Length:	257	Species:	Drosophila melanogaster
Sequence 2:	NP_071779.1	Gene:	Ascl1 / 64186	RGDID:	71010	Length:	233	Species:	Rattus norvegicus

Alignment Length:	242	Identity:	79/242 - (32%)
Similarity:	109/242 - (45%)	Gaps:	69/242 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QHQHHHQTQQHQLIAPKI-PLGTSQLQN-------MQQSQQSNVGPMLSSQKKKFNYNNMPYG-- 79
            |.|...|..|.|  ||:: |:...|...       .|..:|.:..|.|...|::.|::...|.
  Rat    48 QQQQQQQAPQQQ--APQLSPVADGQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNFSGFGYSLP 110

  Fly    80 -EQLPSVARRNARERNRVKQVNNGFVNLRQHLPQTVVNSLSNGGRGSSKKLSKVDTLRIAVEYIR 143
             :|..:|||||.|||||||.||.||..||:|:|        ||  .::||:|||:|||.||||||
  Rat   111 QQQPAAVARRNERERNRVKLVNLGFATLREHVP--------NG--AANKKMSKVETLRSAVEYIR 165

  Fly   144 GLQDMLDDGTASSTRHIYNSADESSNDGSSY-NDYNDSLDSSQQFLTGATQSAQSHSYHSASPTP 207
            .||.:||:..|.|.  .:.:...|.....:| ||.|..                     :.||..
  Rat   166 ALQQLLDEHDAVSA--AFQAGVLSPTISPNYSNDLNSM---------------------AGSPVS 207

  Fly   208 SYSGSEISGGGYIKQELQEQDLKFDSFDSFSDEQPDDEELLDYISSW 254
            |||..|                  .|:|..|   |:::||||: ::|
  Rat   208 SYSSDE------------------GSYDPLS---PEEQELLDF-TNW 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)sc	NP_476623.1	HLH	<96..146	CDD:278439	26/49 (53%)
l(1)sc	NP_476623.1	Peptidase_C11	<128..218	CDD:304483	30/90 (33%)
Ascl1	NP_071779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..95		13/48 (27%)
		HLH	131..173	CDD:197674	27/51 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9554
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I5061
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1131543at2759
OrthoFinder	1	1.000	-	-		FOG0001993
OrthoInspector	1	1.000	-	-		mtm9108
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13935
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2717
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930