DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)sc and MESP1

DIOPT Version :9

Sequence 1:	NP_476623.1	Gene:	l(1)sc / 30983	FlyBaseID:	FBgn0002561	Length:	257	Species:	Drosophila melanogaster
Sequence 2:	NP_061140.1	Gene:	MESP1 / 55897	HGNCID:	29658	Length:	268	Species:	Homo sapiens

Alignment Length:	104	Identity:	29/104 - (27%)
Similarity:	43/104 - (41%)	Gaps:	23/104 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PSVARRNA---------------RERNRVKQVNNGFVNLRQHLPQTVVNSLSNGGRGSSKKLSKV 132
            |||.||.|               ||:.|::.:......||:.||.:|.        .:.:.|:|:
Human    67 PSVGRRGARSSRLGSGQRQSASEREKLRMRTLARALHELRRFLPPSVA--------PAGQSLTKI 123

  Fly   133 DTLRIAVEYIRGLQDMLDDGTASSTRHIYNSADESSNDG 171
            :|||:|:.||..|..:|.....|..|......|..|..|
Human   124 ETLRLAIRYIGHLSAVLGLSEESLQRRCRQRGDAGSPRG 162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)sc	NP_476623.1	HLH	<96..146	CDD:278439	13/49 (27%)
l(1)sc	NP_476623.1	Peptidase_C11	<128..218	CDD:304483	15/44 (34%)
MESP1	NP_061140.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..93		8/25 (32%)
		bHLH_TS_Mesp	83..147	CDD:381508	18/71 (25%)
		CPLCP	163..167		29/104 (28%)
		2 X 2 AA tandem repeats of G-Q	182..185
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810