DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)sc and ASCL1

DIOPT Version :9

Sequence 1:	NP_476623.1	Gene:	l(1)sc / 30983	FlyBaseID:	FBgn0002561	Length:	257	Species:	Drosophila melanogaster
Sequence 2:	NP_004307.2	Gene:	ASCL1 / 429	HGNCID:	738	Length:	236	Species:	Homo sapiens

Alignment Length:	240	Identity:	79/240 - (32%)
Similarity:	108/240 - (45%)	Gaps:	67/240 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QHHHQTQQHQLIAPKI-PLGTSQLQN-------MQQSQQSNVGPMLSSQKKKFNYNNMPYG---E 80
            |...|.||.|..||:: |....|...       .|..:|.:..|.|...|::.|::...|.   :
Human    51 QQQQQQQQQQQQAPQLRPAADGQPSGGGHKSAPKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQ 115

  Fly    81 QLPSVARRNARERNRVKQVNNGFVNLRQHLPQTVVNSLSNGGRGSSKKLSKVDTLRIAVEYIRGL 145
            |..:|||||.|||||||.||.||..||:|:|        ||  .::||:|||:|||.||||||.|
Human   116 QPAAVARRNERERNRVKLVNLGFATLREHVP--------NG--AANKKMSKVETLRSAVEYIRAL 170

  Fly   146 QDMLDDGTASSTRHIYNSADESSNDGSSY-NDYNDSLDSSQQFLTGATQSAQSHSYHSASPTPSY 209
            |.:||:..|.|.  .:.:...|.....:| ||.|..                     :.||..||
Human   171 QQLLDEHDAVSA--AFQAGVLSPTISPNYSNDLNSM---------------------AGSPVSSY 212

  Fly   210 SGSEISGGGYIKQELQEQDLKFDSFDSFSDEQPDDEELLDYISSW 254
            |..|                  .|:|..|   |:::||||: ::|
Human   213 SSDE------------------GSYDPLS---PEEQELLDF-TNW 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)sc	NP_476623.1	HLH	<96..146	CDD:278439	26/49 (53%)
l(1)sc	NP_476623.1	Peptidase_C11	<128..218	CDD:304483	30/90 (33%)
ASCL1	NP_004307.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..98		13/46 (28%)
		bHLH_TS_ASCL1_Mash1	115..185	CDD:381585	43/81 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9706
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	87	1.000	Inparanoid score	I5142
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1131543at2759
OrthoFinder	1	1.000	-	-		FOG0001993
OrthoInspector	1	1.000	-	-		otm41464
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13935
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3926
SonicParanoid	1	1.000	-	-		X2717
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.960