DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)sc and LYL1

DIOPT Version :9

Sequence 1:	NP_476623.1	Gene:	l(1)sc / 30983	FlyBaseID:	FBgn0002561	Length:	257	Species:	Drosophila melanogaster
Sequence 2:	NP_005574.2	Gene:	LYL1 / 4066	HGNCID:	6734	Length:	280	Species:	Homo sapiens

Alignment Length:	206	Identity:	53/206 - (25%)
Similarity:	77/206 - (37%)	Gaps:	57/206 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LLQHQHHHQTQQHQLIAPKIPLGTSQLQNMQQSQQSNVGPMLSSQKKKFNYN---NMPYGEQLPS 84
            |..|.|.|.......|.|..|.              ::.|  ||:.|:...:   ::..|.|...
Human   100 LALHYHPHPFLNSVYIGPAGPF--------------SIFP--SSRLKRRPSHCELDLAEGHQPQK 148

  Fly    85 VARR---NARERNRVKQVNNGFVNLRQHLPQTVVNSLSNGGRGSSKKLSKVDTLRIAVEYIRGLQ 146
            ||||   |:|||.|.:.||..|..||:.||.          ....:||||.:.||:|::||..|.
Human   149 VARRVFTNSRERWRQQNVNGAFAELRKLLPT----------HPPDRKLSKNEVLRLAMKYIGFLV 203

  Fly   147 DMLDDGTAS----------STRHIYNSADESSNDGSSYNDYNDSLDSSQQFLTGATQSAQSHSYH 201
            .:|.|..|:          ..|.::...|:.:..||...               |..:|:|....
Human   204 RLLRDQAAALAAGPTPPGPRKRPVHRVPDDGARRGSGRR---------------AEAAARSQPAP 253

  Fly   202 SASPTPSYSGS 212
            .|.|..|..|:
Human   254 PADPDGSPGGA 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)sc	NP_476623.1	HLH	<96..146	CDD:278439	16/49 (33%)
l(1)sc	NP_476623.1	Peptidase_C11	<128..218	CDD:304483	24/95 (25%)
LYL1	NP_005574.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..60
		HLH	156..208	CDD:197674	23/61 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..280		11/66 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810