DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)sc and Ascl1

DIOPT Version :9

Sequence 1:	NP_476623.1	Gene:	l(1)sc / 30983	FlyBaseID:	FBgn0002561	Length:	257	Species:	Drosophila melanogaster
Sequence 2:	NP_032579.2	Gene:	Ascl1 / 17172	MGIID:	96919	Length:	231	Species:	Mus musculus

Alignment Length:	241	Identity:	80/241 - (33%)
Similarity:	106/241 - (43%)	Gaps:	76/241 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QQHQLIAPKIPLGTSQLQNMQQSQQSNVG---------------PMLSSQKKKFNYNNMPYG--- 79
            ||.|..||  |....||..:..||.|..|               |.|...|::.|::...|.
Mouse    47 QQQQPQAP--PQQAPQLSPVADSQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQ 109

  Fly    80 EQLPSVARRNARERNRVKQVNNGFVNLRQHLPQTVVNSLSNGGRGSSKKLSKVDTLRIAVEYIRG 144
            :|..:|||||.|||||||.||.||..||:|:|        ||  .::||:|||:|||.||||||.
Mouse   110 QQPAAVARRNERERNRVKLVNLGFATLREHVP--------NG--AANKKMSKVETLRSAVEYIRA 164

  Fly   145 LQDMLDDGTASSTRHIYNSADESSNDGSSY-NDYNDSLDSSQQFLTGATQSAQSHSYHSASPTPS 208
            ||.:||:..|.|.  .:.:...|.....:| ||.|..                     :.||..|
Mouse   165 LQQLLDEHDAVSA--AFQAGVLSPTISPNYSNDLNSM---------------------AGSPVSS 206

  Fly   209 YSGSEISGGGYIKQELQEQDLKFDSFDSFSDEQPDDEELLDYISSW 254
            ||..|                  .|:|..|   |:::||||: ::|
Mouse   207 YSSDE------------------GSYDPLS---PEEQELLDF-TNW 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)sc	NP_476623.1	HLH	<96..146	CDD:278439	26/49 (53%)
l(1)sc	NP_476623.1	Peptidase_C11	<128..218	CDD:304483	30/90 (33%)
Ascl1	NP_032579.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..92		13/46 (28%)
		HLH	129..171	CDD:197674	27/51 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9760
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I5162
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1131543at2759
OrthoFinder	1	1.000	-	-		FOG0001993
OrthoInspector	1	1.000	-	-		mtm11115
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13935
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3926
SonicParanoid	1	1.000	-	-		X2717
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.960