DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sc and Ascl1

DIOPT Version :9

Sequence 1:	NP_476803.1	Gene:	sc / 30982	FlyBaseID:	FBgn0004170	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_071779.1	Gene:	Ascl1 / 64186	RGDID:	71010	Length:	233	Species:	Rattus norvegicus

Alignment Length:	193	Identity:	65/193 - (33%)
Similarity:	95/193 - (49%)	Gaps:	31/193 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 QHIMPAPSPLI---PGGNQNQPAGTMPIKTRKYTPRGMALTRCSESVSSLSPGSSPAPYNVDQSQ 99
            |...|..||:.   |.|..::.|.....:.|..:|.   |.||...::....|     |::.|.|
  Rat    57 QQQAPQLSPVADGQPSGGGHKSAAKQVKRQRSSSPE---LMRCKRRLNFSGFG-----YSLPQQQ 113

  Fly   100 --SVQRRNARERNRVKQVNNSFARLRQHIPQSIITDLTKGGGRGPHKKISKVDTLRIAVEYIRRL 162
              :|.|||.|||||||.||..||.||:|:|..           ..:||:|||:|||.||||||.|
  Rat   114 PAAVARRNERERNRVKLVNLGFATLREHVPNG-----------AANKKMSKVETLRSAVEYIRAL 167

  Fly   163 QDLVDDLNGGSNIGANNAVTQL-QLCLDESSSHSSSSSTCSSSGHNTYYQNTISVSPLQQQQQ 224
            |.|:|:.:      |.:|..|. .|....|.::|:..::.:.|..::|..:..|..||..::|
  Rat   168 QQLLDEHD------AVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQ 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sc	NP_476803.1	HLH	105..163	CDD:278439	30/57 (53%)
Ascl1	NP_071779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..95		10/40 (25%)
		HLH	131..173	CDD:197674	25/52 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9554
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I5061
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1131543at2759
OrthoFinder	1	1.000	-	-		FOG0001993
OrthoInspector	1	1.000	-	-		mtm9108
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.830