DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sc and ASCL1

DIOPT Version :9

Sequence 1:	NP_476803.1	Gene:	sc / 30982	FlyBaseID:	FBgn0004170	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_004307.2	Gene:	ASCL1 / 429	HGNCID:	738	Length:	236	Species:	Homo sapiens

Alignment Length:	187	Identity:	61/187 - (32%)
Similarity:	93/187 - (49%)	Gaps:	29/187 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SPLIPGGNQNQPAG----TMPIKTRKYTPRGMALTRCSESVSSLSPGSSPAPYNVDQSQ--SVQR 103
            :|.:......||:|    :.|.:.::.......|.||...::....|     |::.|.|  :|.|
Human    63 APQLRPAADGQPSGGGHKSAPKQVKRQRSSSPELMRCKRRLNFSGFG-----YSLPQQQPAAVAR 122

  Fly   104 RNARERNRVKQVNNSFARLRQHIPQSIITDLTKGGGRGPHKKISKVDTLRIAVEYIRRLQDLVDD 168
            ||.|||||||.||..||.||:|:|..           ..:||:|||:|||.||||||.||.|:|:
Human   123 RNERERNRVKLVNLGFATLREHVPNG-----------AANKKMSKVETLRSAVEYIRALQQLLDE 176

  Fly   169 LNGGSNIGANNAVTQL-QLCLDESSSHSSSSSTCSSSGHNTYYQNTISVSPLQQQQQ 224
            .:      |.:|..|. .|....|.::|:..::.:.|..::|..:..|..||..::|
Human   177 HD------AVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQ 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sc	NP_476803.1	HLH	105..163	CDD:278439	30/57 (53%)
ASCL1	NP_004307.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..98		6/34 (18%)
		bHLH_TS_ASCL1_Mash1	115..185	CDD:381585	40/86 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9706
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	87	1.000	Inparanoid score	I5142
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1131543at2759
OrthoFinder	1	1.000	-	-		FOG0001993
OrthoInspector	1	1.000	-	-		otm41464
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.830