DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sc and ascl1a

DIOPT Version :9

Sequence 1:	NP_476803.1	Gene:	sc / 30982	FlyBaseID:	FBgn0004170	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_571294.1	Gene:	ascl1a / 30466	ZFINID:	ZDB-GENE-980526-90	Length:	196	Species:	Danio rerio

Alignment Length:	199	Identity:	65/199 - (32%)
Similarity:	97/199 - (48%)	Gaps:	37/199 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 QHIMPAPS--------PLIPGGNQ--NQPAGTMPIKTRKYTPRGMALTRCSESVSSLSPGSSPAP 92
            |..|| |:        .|.|..:|  |:.|.....:.|..:|.   |.||...::....|
Zfish    14 QQFMP-PACFFASQSIQLSPTDSQCSNKSASKQAKRQRSSSPE---LLRCKRRLNFAGFG----- 69

  Fly    93 YNVDQSQ--SVQRRNARERNRVKQVNNSFARLRQHIPQSIITDLTKGGGRGPHKKISKVDTLRIA 155
            |::.|.|  :|.|||.|||||||.|||.||.||:|:|..           ..:||:|||:|||.|
Zfish    70 YSLPQQQPHAVARRNERERNRVKLVNNGFATLREHVPNG-----------AANKKMSKVETLRSA 123

  Fly   156 VEYIRRLQDLVDDLNGGSNIGANNAVTQLQLCLDESSSHSSSSSTCSSSGHNTYYQNTISVSPLQ 220
            |||||.||.|:|:.:..|....:..::.     ..|.::|:..::.:.|..::|..:..|..||.
Zfish   124 VEYIRALQQLLDEHDAVSAAFQSGVLSP-----TISQNYSNDMNSMAGSPVSSYSSDEGSYDPLS 183

  Fly   221 QQQQ 224
            .::|
Zfish   184 PEEQ 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sc	NP_476803.1	HLH	105..163	CDD:278439	31/57 (54%)
ascl1a	NP_571294.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..54		4/20 (20%)
		HLH	94..136	CDD:197674	26/52 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..186		5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594069
Domainoid	1	1.000	69	1.000	Domainoid score	I9565
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I5117
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1131543at2759
OrthoFinder	1	1.000	-	-		FOG0001993
OrthoInspector	1	1.000	-	-		mtm6567
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.760