DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sc and Ascl1

DIOPT Version :9

Sequence 1:	NP_476803.1	Gene:	sc / 30982	FlyBaseID:	FBgn0004170	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_032579.2	Gene:	Ascl1 / 17172	MGIID:	96919	Length:	231	Species:	Mus musculus

Alignment Length:	189	Identity:	64/189 - (33%)
Similarity:	94/189 - (49%)	Gaps:	31/189 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 PAPSPLI---PGGNQNQPAGTMPIKTRKYTPRGMALTRCSESVSSLSPGSSPAPYNVDQSQ--SV 101
            |..||:.   |.|..::.|.....:.|..:|.   |.||...::....|     |::.|.|  :|
Mouse    59 PQLSPVADSQPSGGGHKSAAKQVKRQRSSSPE---LMRCKRRLNFSGFG-----YSLPQQQPAAV 115

  Fly   102 QRRNARERNRVKQVNNSFARLRQHIPQSIITDLTKGGGRGPHKKISKVDTLRIAVEYIRRLQDLV 166
            .|||.|||||||.||..||.||:|:|..           ..:||:|||:|||.||||||.||.|:
Mouse   116 ARRNERERNRVKLVNLGFATLREHVPNG-----------AANKKMSKVETLRSAVEYIRALQQLL 169

  Fly   167 DDLNGGSNIGANNAVTQL-QLCLDESSSHSSSSSTCSSSGHNTYYQNTISVSPLQQQQQ 224
            |:.:      |.:|..|. .|....|.::|:..::.:.|..::|..:..|..||..::|
Mouse   170 DEHD------AVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQ 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sc	NP_476803.1	HLH	105..163	CDD:278439	30/57 (53%)
Ascl1	NP_032579.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..92		8/35 (23%)
		HLH	129..171	CDD:197674	25/52 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9760
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I5162
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1131543at2759
OrthoFinder	1	1.000	-	-		FOG0001993
OrthoInspector	1	1.000	-	-		mtm11115
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.830