DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sc and TCF23

DIOPT Version :9

Sequence 1:	NP_476803.1	Gene:	sc / 30982	FlyBaseID:	FBgn0004170	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_786951.1	Gene:	TCF23 / 150921	HGNCID:	18602	Length:	214	Species:	Homo sapiens

Alignment Length:	135	Identity:	36/135 - (26%)
Similarity:	55/135 - (40%)	Gaps:	43/135 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 APSPLIPGGNQNQPAGTM----PIKTRKYT----------PRGMALTRCSESVSSLSPGSSPA-P 92
            |.:.|:||.::.:...:.    |.:.|.::          |||   ||    ...|:.|.|.| |
Human    22 AKARLLPGADRKRSRLSRTRQDPWEERSWSNQRWSRATPGPRG---TR----AGGLALGRSEASP 79

  Fly    93 YNVDQSQSVQRRNARERNRVKQVNNSFARLRQHIPQSIITDLTKGGGRGPHKKISKVDTLRIAVE 157
            .|.          ||||:||:.:..:|..|:..:|           ...|..|:||:|.|.:|..
Human    80 ENA----------ARERSRVRTLRQAFLALQAALP-----------AVPPDTKLSKLDVLVLAAS 123

  Fly   158 YIRRL 162
            ||..|
Human   124 YIAHL 128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sc	NP_476803.1	HLH	105..163	CDD:278439	19/58 (33%)
TCF23	NP_786951.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..86		19/80 (24%)
		HLH	83..132	CDD:197674	19/57 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..214
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810