DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ac and Ascl1

DIOPT Version :9

Sequence 1:	NP_476824.1	Gene:	ac / 30981	FlyBaseID:	FBgn0000022	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_071779.1	Gene:	Ascl1 / 64186	RGDID:	71010	Length:	233	Species:	Rattus norvegicus

Alignment Length:	173	Identity:	57/173 - (32%)
Similarity:	81/173 - (46%)	Gaps:	56/173 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SVIRRNARERNRVKQVNNGFSQLRQHIPAAVIADLSNGRRGIGPGANKKLSKVSTLKMAVEYIRR 89
            :|.|||.|||||||.||.||:.||:|:|        ||      .||||:|||.||:.||||||.
  Rat   116 AVARRNERERNRVKLVNLGFATLREHVP--------NG------AANKKMSKVETLRSAVEYIRA 166

  Fly    90 LQKVLHENDQQKQKQLHLQQQHLHFQQQQQHQHLYAWHQELQLQSPTGSTSSCNSISSYCKPATS 154
            ||::|.|:|.....          ||              ..:.|||.|.:..|.::|.
  Rat   167 LQQLLDEHDAVSAA----------FQ--------------AGVLSPTISPNYSNDLNSM------ 201

  Fly   155 TIPGATPPNNFHTKLEASFEDYRNNSCSSGTEDEDILDYISLW 197
                |..|.:.::..|.|::..       ..|::::||:.: |
  Rat   202 ----AGSPVSSYSSDEGSYDPL-------SPEEQELLDFTN-W 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ac	NP_476824.1	HLH	30..96	CDD:197674	36/65 (55%)
Ascl1	NP_071779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..95
		HLH	131..173	CDD:197674	28/55 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352165
Domainoid	1	1.000	67	1.000	Domainoid score	I9554
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I5061
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1131543at2759
OrthoFinder	1	1.000	-	-		FOG0001993
OrthoInspector	1	1.000	-	-		mtm9108
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2717
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.760