DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ac and ascl1a

DIOPT Version :9

Sequence 1:	NP_476824.1	Gene:	ac / 30981	FlyBaseID:	FBgn0000022	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_571294.1	Gene:	ascl1a / 30466	ZFINID:	ZDB-GENE-980526-90	Length:	196	Species:	Danio rerio

Alignment Length:	173	Identity:	58/173 - (33%)
Similarity:	82/173 - (47%)	Gaps:	56/173 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SVIRRNARERNRVKQVNNGFSQLRQHIPAAVIADLSNGRRGIGPGANKKLSKVSTLKMAVEYIRR 89
            :|.|||.|||||||.|||||:.||:|:|        ||      .||||:|||.||:.||||||.
Zfish    79 AVARRNERERNRVKLVNNGFATLREHVP--------NG------AANKKMSKVETLRSAVEYIRA 129

  Fly    90 LQKVLHENDQQKQKQLHLQQQHLHFQQQQQHQHLYAWHQELQLQSPTGSTSSCNSISSYCKPATS 154
            ||::|.|:|.....          ||.              .:.|||.|.:..|.::|.
Zfish   130 LQQLLDEHDAVSAA----------FQS--------------GVLSPTISQNYSNDMNSM------ 164

  Fly   155 TIPGATPPNNFHTKLEASFEDYRNNSCSSGTEDEDILDYISLW 197
                |..|.:.::..|.|::..       ..|::::||:.: |
Zfish   165 ----AGSPVSSYSSDEGSYDPL-------SPEEQELLDFTN-W 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ac	NP_476824.1	HLH	30..96	CDD:197674	37/65 (57%)
ascl1a	NP_571294.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..54
		HLH	94..136	CDD:197674	29/55 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..186		6/43 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594066
Domainoid	1	1.000	69	1.000	Domainoid score	I9565
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I5117
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1131543at2759
OrthoFinder	1	1.000	-	-		FOG0001993
OrthoInspector	1	1.000	-	-		mtm6567
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3926
SonicParanoid	1	1.000	-	-		X2717
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.790