DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment y and yellow-e

DIOPT Version :9

Sequence 1:	NP_476792.1	Gene:	y / 30980	FlyBaseID:	FBgn0004034	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_524344.1	Gene:	yellow-e / 41653	FlyBaseID:	FBgn0041711	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	145/554 - (26%)
Similarity:	235/554 - (42%)	Gaps:	96/554 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILVTLITLVTPSWAAYK------LQERYSWSQLDFAF-PNTRLKDQALASGDYIPQNALPVGVEH 65
            |||.:|..|.  |:...      ||....|..|.:.| |...:.|...    |.|||.|..|:..
  Fly     4 ILVGVICAVL--WSPVSQALTPGLQVAKQWKLLRYNFEPQAPVSDPNF----YNPQNVLITGLAV 62

  Fly    66 FGNRLFVTVPRWRDGIPATLTYINMDRSLTGSPELIPYPDWRSNTAG----DCANSI-TTAYRIK 125
            ..:|:||..|:...|:|:|::::: ......||.|..:|||..:..|    :|::.| |:.||::
  Fly    63 TDDRIFVATPKLFSGVPSTVSWVS-KAQFGDSPTLNAFPDWTFSNTGRSDFNCSDLILTSVYRLR 126

  Fly   126 VDECGRLWVLDTGTVGIGNTTTNPCPYAVNVFDLTTDTRIRRYELPGVDTNPNTFIANIAVD--I 188
            ||.|.|:|:||.|...........||..:.|.||.||..:||.:.|.......:...|:.:|  .
  Fly   127 VDSCNRIWLLDAGISRSLEDYEITCPPKILVVDLATDRVVRRIDFPPEVLRGESLFTNMVIDETT 191

  Fly   189 GKNCDDAYAYFADELGYGLIAYSWELNKSWRFSAHSYFFPDPLRGDFNVAGINFQWGE------E 247
            .|.|||.:.|..|.:..|:|.|....:.:||.| |...:|||   ||..:.|:    |      :
  Fly   192 AKGCDDVFVYITDTVEPGIIVYDSGKDVTWRVS-HPAMYPDP---DFAQSEIH----EHRFVLMD 248

  Fly   248 GIFGMSLSPIRSDGYRT--LYFSPLASHRQFAVSTRILRDETRTEDSYHDFVALDERGPNSHTTS 310
            |:.|::...      ||  :||.|||:.|.|:|...:||.....:....| |.|..:..:.....
  Fly   249 GVVGLTFDE------RTGVVYFQPLATDRVFSVHKNVLRAGPLPDGKMLD-VKLVGKKSSQGIGL 306

  Fly   311 RVMSDDGIELFNLIDQNAVGCWHSSMPYSPQFHGIV-DRDDVGLVFPADVKIDENKN--VWVLSD 372
            .|...|...:|:.:.:.|:..|:   |.:.|...:. |||.  |.|.||:...:::.  ::.::.
  Fly   307 AVSPFDSSLIFSPLSETAIASWN---PTTNQQSVLAFDRDQ--LQFVADITTTKSEPGVIYAIAS 366

  Fly   373 RMPVFLLSDLDYSDTNFRIYTAPLA---TLIENTVC--------DLRN----NAYGPPNTVSIPK 422
            :...|.|.:|:.::.|.||....|.   :|:.:.|.        .|.|    |.:|..:|.::..
  Fly   367 KFHRFFLKNLNPNEFNNRIVRLELPAGNSLLGHRVALPAPPTHNSLLNYGVFNTHGQASTNALQT 431

  Fly   423 QAVLP-MGPPLYTKQYRPVLPQKPQT----SWASSPP----------PPSRTYLPANSGNVVSS- 471
            ....| :..|..||.     |.|.:|    ::::..|          |||:    |...|...|
  Fly   432 YFTSPALTTPFTTKS-----PFKFETGGIVNYSARNPFTALNQGEAFPPSK----ATRDNFQRSY 487

  Fly   472 ISVSTNSVGPAG----VEVPKAYIFNQHNGINYE 501
            :.....:..||.    |.||......:|:|..|:
  Fly   488 LDTLVGTTSPAATTRVVSVPPTAFSGRHSGYYYQ 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
y	NP_476792.1	MRJP	119..405	CDD:308585	82/301 (27%)
yellow-e	NP_524344.1	MRJP	120..393	CDD:281074	81/292 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449236
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3386
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D940689at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10009
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850