DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HK1 and Hex-A

DIOPT Version :9

Sequence 1:NP_001309294.1 Gene:HK1 / 3098 HGNCID:4922 Length:952 Species:Homo sapiens
Sequence 2:NP_524848.1 Gene:Hex-A / 45875 FlyBaseID:FBgn0001186 Length:541 Species:Drosophila melanogaster


Alignment Length:453 Identity:215/453 - (47%)
Similarity:299/453 - (66%) Gaps:14/453 - (3%)


- Green bases have known domain annotations that are detailed below.


Human   499 AEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDF 563
            ||:.:.:.|......||.:.:.|:..|:..|:..||.|.||..|.||...::|:..|:|.|.|.|
  Fly    89 AEKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGKF 153

Human   564 LALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKG 628
            ||||||||||||||:.::  :....:|.::|||||..||.|:|.:|||||..|:|:|:....:..
  Fly   154 LALDLGGTNFRVLLIHLQ--ENNDFQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFMAEHNVYK 216

Human   629 PRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDT 693
            .|:|||||||||.:|..|..|:|.||||||.....|..|||.||:|||.||.:..:||.|::|||
  Fly   217 ERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDT 281

Human   694 VGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGD---QGQMCINMEWGAFGDNGCLDD 755
            .||:|:||::...|::|||||||:||||||.::..|:...:   :..:.||.|||||||||.||.
  Fly   282 TGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNGALDF 346

Human   756 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETK 820
            :||.:||.:|.:|:|.|||.:||||||||:||:||.:|:..|:.|.||.||.||.|.|||:|.||
  Fly   347 VRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGLFFTK 411

Human   821 FLSQIESDRLA-LLQVRAILQQLGL-NSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIREN 883
            ::|:||:|... ....|.:|::||| |:|..|...|:.:|..||:|||.|..||:|.:::|    
  Fly   412 YVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLINK---- 472

Human   884 RGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKEL-SPKCNVSFLLSEDGSGKGAALITAVGVR 945
              :|...|||||||::|:.||.|..:|.:.:.:| .|......:|||||||:||||:.||..|
  Fly   473 --MDEPTVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLMLSEDGSGRGAALVAAVACR 533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HK1NP_001309294.1 PTZ00107 47..495 CDD:240270
Hexokinase_1 56..254 CDD:278764
Hexokinase_2 260..494 CDD:281689
PTZ00107 497..942 CDD:240270 212/448 (47%)
Hexokinase_1 504..702 CDD:278764 93/197 (47%)
Hexokinase_2 708..942 CDD:281689 115/239 (48%)
Hex-ANP_524848.1 Hexokinase_1 95..290 CDD:395278 93/196 (47%)
Hexokinase_2 296..530 CDD:397683 115/239 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 225 1.000 Domainoid score I2536
eggNOG 1 0.900 - - E1_COG5026
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H100530
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1153545at2759
OrthoFinder 1 1.000 - - FOG0000301
OrthoInspector 1 1.000 - - mtm8559
orthoMCL 1 0.900 - - OOG6_100418
Panther 1 1.100 - - O PTHR19443
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2154
SonicParanoid 1 1.000 - - X170
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.850

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