Protein Alignment ewg and NRF1

DIOPT Version :9

• Sequence 1: NP_001245444.1
• Gene: ewg / 30975
• FlyBaseID: FBgn0005427
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_001280092.1
• Gene: NRF1 / 4899
• HGNCID: 7996
• Length: 522
• Species: Homo sapiens
• Alignment Length: 625
• Identity: 228/625 - (36%)
• Similarity: 315/625 - (50%)
• Gaps: 127/625 - (20%)

  Fly    69 LQSAGNTSQSNGTTYKIEMLEEDIQ----------SLGSDDDDEDLISSDGSLYEGDLGSMPVND 123
            ::..|.|...:..|.:...:.:.:|          |:.|.|:|......|.|..:.|:.:....|
Human     1 MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAAD 65

  Fly   124 DVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRAIIYEFTGRVGKQA 188
            :|...||||||||:|||||:|:.|||||||.||:|||:|||||.||||||||.:.|:|.|||:||
Human    66 EVTAHLAAAGPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQA 130

  Fly   189 VVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQDDPSLFELPGLVIDG 253
            :||..:|.|||..:|||||.|||:|:|..|::::::|::|||:.||.|.:.:.   |||.|.|||
Human   131 IVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQEVNS---ELPPLTIDG 192

  Fly   254 IPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKVG 318
            ||..|:||||||||||||.||||||||||||||:||.:|.|||:::||||||.|.|:|:.||:|
Human   193 IPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRV- 256

  Fly   319 GISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMELSNPPTIHTVTTMTP 383
              |||.|||.||.||||.|||||||..|.|.:.:..|..:.|             ..|.|.:.|.
Human   257 --SWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQATATHS-------------IAHLVPSQTV 306

  Fly   384 PTGNSNQPQQVNVVKINSAGTVITTHTAQSNTPAPTIIQSTNNQHVTTTATLPASTKIEICQAPA 448
            ....||....|:::::.:..||.|...| |..|....:...|...|       |..::|...|..
Human   307 VQTFSNPDGTVSLIQVGTGATVATLADA-SELPTTVTVAQVNYSAV-------ADGEVEQNWATL 363

  Fly   449 QNQQHHQHHQTHLPNAVHIQPVAGGQPQTIQLTTASGTATATAVQTTAAAVSAAQAHAHSQSQAH 513
            |                      ||: .|||.|.|| .||........|||:|:|.
Human   364 Q----------------------GGE-MTIQTTQAS-EATQAVASLAEAAVAASQE--------- 395

  Fly   514 SQSSANQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTA 578
                                                :.|.|..|::|......:.:.||.:.|
Human   396 ------------------------------------MQQGATVTMALNSEAAAHAVATLAEAT-- 422

  Fly   579 QVQGVATL-HQGEGGATIQTVQSLTDVNGHENMTVDLTETQDGQIYITTEDGQGYPVSVSNVISV 642
             :||...: ..||..|.:..:..:.|.||.      ....:.|:.:|.|:...|       ::.:
Human   423 -LQGGGQIVLSGETAAAVGALTGVQDANGL------FMADRAGRKWILTDKATG-------LVQI 473

  Fly   643 PVSMYQSVMANVQQIQTNSDGTVCLAPMQVDTSINRSTST 682
            ||||||:|:.::.|    .:|.|.:|...|.|.|:.|..|
Human   474 PVSMYQTVVTSLAQ----GNGPVQVAMAPVTTRISDSAVT 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ewg	NP_001245444.1	Nrf1_DNA-bind	145..347	CDD:287464	129/201 (64%)
		Nrf1_activ_bdg	637..>672	CDD:256023	11/34 (32%)
NRF1	NP_001280092.1	Nrf1_DNA-bind	87..283	CDD:402218	129/201 (64%)
		Nrf1_activ_bdg	468..>512	CDD:313673	17/53 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140691
Domainoid	1	1.000	295	1.000	Domainoid score	I1489
eggNOG	1	0.900	-	-		E1_2C0QX
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	332	1.000	Inparanoid score	I2428
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368670at33208
OrthoFinder	1	1.000	-	-		FOG0008233
OrthoInspector	1	1.000	-	-		oto89620
orthoMCL	1	0.900	-	-		OOG6_108487
Panther	1	1.100	-	-	LDO	PTHR20338
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4559
SonicParanoid	1	1.000	-	-		X7277
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790