Protein Alignment ewg and Nrf1

DIOPT Version :9

• Sequence 1: NP_001245444.1
• Gene: ewg / 30975
• FlyBaseID: FBgn0005427
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_006505068.1
• Gene: Nrf1 / 18181
• MGIID: 1332235
• Length: 546
• Species: Mus musculus
• Alignment Length: 599
• Identity: 221/599 - (36%)
• Similarity: 305/599 - (50%)
• Gaps: 107/599 - (17%)

  Fly    69 LQSAGNTSQSNGTTYKIEMLEEDIQ----------SLGSDDDDEDLISSDGSLYEGDLGSMPVND 123
            ::..|.|...:..|.:...:.:.:|          |:.|.|:|......|.|..:.|:.:....|
Mouse     1 MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAAD 65

  Fly   124 DVAHQLAAA------------GPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRAI 176
            :|...||||            ||||:|||||:|:.|||||||.||:|||:|||||.||||||||.
Mouse    66 EVTAHLAAAVLGIKPRASHILGPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQTRLLRKLRAT 130

  Fly   177 IYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQDDP 241
            :.|:|.|||:||:||..:|.|||..:|||||.|||:|:|..|::::::|::|||:.||.|.:.:.
Mouse   131 LDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQEVNS 195

  Fly   242 SLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRM 306
               |||.|.|||||..|:||||||||||||.||||||||||||||:||.:|.|||:::||||||.
Mouse   196 ---ELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRS 257

  Fly   307 DARSEDDKQKVGGISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMELSN 371
            |.|:|:.||:|   |||.|||.||.||||.|||||||..|.|.:.:..|..:.|
Mouse   258 DVRTEEQKQRV---SWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQATTTHS----------- 308

  Fly   372 PPTIHTVTTMTPPTGNSNQPQQVNVVKINSAGTVITTHTAQSNTPAPTIIQSTNNQHVTTTATLP 436
              ..|.|.:.|.....||....|:::::.:..||.|...| |..|....:...|...|
Mouse   309 --IAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADA-SELPTTVTVAQVNYSAV------- 363

  Fly   437 ASTKIEICQAPAQNQQHHQHHQTHLPNAVHIQPVAGGQPQTIQLTTASGTATATAVQTTAAAVSA 501
            |..::|...|..|                      ||: .|||.|.||        :.|.|..|.
Mouse   364 ADGEVEQNWATLQ----------------------GGE-MTIQTTQAS--------EATQAVASL 397

  Fly   502 AQAHAHSQSQAHSQSSANQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQN---ADGTVSLIQV 563
            |:|...:..:....::....:.::..|:|...:...||..   ..|.|||..   |.|.::.:|
Mouse   398 AEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQG---GGQIVLSGETAAAVGALTGVQ- 458

  Fly   564 DPNNP----IITLPDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTET------- 617
            |.|.|    ..|:....||. |....:|...|...|     :.:|...|::..:.:|.
Mouse   459 DANGPDGVHAWTISKAVTAP-QAAGKIHTDFGKGFI-----MAEVMKDEDLKEESSENAAKAAGK 517

  Fly   618 --QDGQIYITTEDG 629
              |.|:.|: .|||
Mouse   518 YKQQGRAYV-VEDG 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ewg	NP_001245444.1	Nrf1_DNA-bind	145..347	CDD:287464	129/201 (64%)
		Nrf1_activ_bdg	637..>672	CDD:256023
Nrf1	XP_006505068.1	Nrf1_DNA-bind	87..295	CDD:371088	139/213 (65%)
		TGS_YchF_OLA1	462..537	CDD:340516	17/76 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830664
Domainoid	1	1.000	295	1.000	Domainoid score	I1480
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	333	1.000	Inparanoid score	I2402
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008233
OrthoInspector	1	1.000	-	-		oto93189
orthoMCL	1	0.900	-	-		OOG6_108487
Panther	1	1.100	-	-	LDO	PTHR20338
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4559
SonicParanoid	1	1.000	-	-		X7277
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.880