Protein Alignment ewg and nrf1

DIOPT Version :9

• Sequence 1: NP_001245444.1
• Gene: ewg / 30975
• FlyBaseID: FBgn0005427
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_002931891.1
• Gene: nrf1 / 100488083
• XenbaseID: XB-GENE-980602
• Length: 527
• Species: Xenopus tropicalis
• Alignment Length: 637
• Identity: 231/637 - (36%)
• Similarity: 318/637 - (49%)
• Gaps: 145/637 - (22%)

  Fly    57 NVTTITA--TSGGQLQSAGNTSQSNGTTY-KIEMLEEDIQSLGSDD----DDEDLISSDGSLYEG 114
            ::|||.|  .:.....|.....|.:..|| ...||..|..|..|.:    ||.|:::|..:
 Frog    12 SLTTIEAHTVAHSVAHSVQQVQQVHVATYTDHNMLSADEDSPSSPEDTSYDDSDILNSTAT---- 72

  Fly   115 DLGSMPVNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRAIIYE 179
                    |::...||||||||:|||||:|:.|||||||.||:|||:|||||.||||||||.:.|
 Frog    73 --------DEITAHLAAAGPVGMAAAAAVATGKKRKRPHIFESNPSIRKRQQTRLLRKLRATLDE 129

  Fly   180 FTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQDDPSLF 244
            :|.|||:||:||..:|.|||..:|||||.|||:|:|..|::::::|::|||:.| |..||..|
 Frog   130 YTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHA-PVQQDINS-- 191

  Fly   245 ELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDAR 309
            :||.|.|||||..|:||||||||||||.||||||||||||||:||.:|.|||.::||||||.|.|
 Frog   192 DLPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPDDIPWANVRSDVR 256

  Fly   310 SEDDKQKVGGISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMELSNPPT 374
            :|:.||:|   |||.|||.||.||||.|||||||..|                  ||.:.:...|
 Frog   257 TEEQKQRV---SWTQALRTIVKNCYKQHGREDLLYAF------------------EDSQTTQVAT 300

  Fly   375 IHTVTTMTPP----TGNSNQPQQVNVVKINSAGTVITTHTAQSNTPAPTIIQSTNNQHVTTTATL 435
            .|.:..:.|.    ...||....|:::::.:..||.|...|   :..||.:         |.|.:
 Frog   301 THGIAHLVPSQTVVQTISNPDGTVSLIQVGTGATVATLADA---SELPTTV---------TVAQV 353

  Fly   436 PASTKIEICQAPAQNQQHHQHHQTHLPNAVHIQPVAGGQPQTIQLTTASGTATATAVQTTAAAVS 500
            ..||        ..:.:..|:..|          :.||: .|||.|.||     .|.|..|:...
 Frog   354 NYST--------VSDGEVEQNWAT----------LQGGE-MTIQTTQAS-----EATQAVASLAE 394

  Fly   501 AAQAHAHSQSQAHSQSSANQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDP 565
            ||.|.:|..:..   ::....:.::..|:|...:...||..   ..|.|||
 Frog   395 AAVAASHDMAPG---ATVTMALNSEAAAHAVATLAEATLQG---GGQIVLS-------------- 439

  Fly   566 NNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTETQDGQIYITTEDGQ 630
                                   ||..|.:..:..:.|.||.....:.:.|:          ||:
 Frog   440 -----------------------GETAAAVGALTGVQDANGAIWKRIVMKES----------DGR 471

  Fly   631 GYPVSVSNVISVPVSMYQSVMANVQQIQTNSDGTVCLAPMQVDTSINRSTST 682
            .     ..::.:||||||:|:.::    |..:|.|.:|...|...|:.||.|
 Frog   472 N-----KGLVQIPVSMYQTVVTSL----TQGNGPVQVAMAPVTARISDSTVT 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ewg	NP_001245444.1	Nrf1_DNA-bind	145..347	CDD:287464	130/201 (65%)
		Nrf1_activ_bdg	637..>672	CDD:256023	11/34 (32%)
nrf1	XP_002931891.1	Nrf1_DNA-bind	95..291	CDD:371088	131/219 (60%)
		Nrf1_activ_bdg	474..>517	CDD:313673	16/45 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	290	1.000	Domainoid score	I1525
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2490
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368670at33208
OrthoFinder	1	1.000	-	-		FOG0008233
OrthoInspector	1	1.000	-	-		oto103441
Panther	1	1.100	-	-	LDO	PTHR20338
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7277
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160