Protein Alignment cin and Gphn

DIOPT Version :10

• Sequence 1: NP_477030.1
• Gene: cin / 30973
• FlyBaseID: FBgn0000316
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: XP_006515964.1
• Gene: Gphn / 268566
• MGIID: 109602
• Length: 839
• Species: Mus musculus
• Alignment Length: 832
• Identity: 242/832 - (29%)
• Similarity: 363/832 - (43%)
• Gaps: 253/832 - (30%)

  Fly     4 ITFGVLTISDTCWQEPEKDTSGPILRQLIGE--TFANTQVIGNIVPDEKDIIQQELRKWIDREEL 66
            |..||||:||:|::...:|.||..|:.|:.:  ....|.....|||||.:.|::.|..|.|.:||
Mouse    15 IRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKEL 79

  Fly    67 RVILTTGGTGFAPRDVTPE-------------ATRQLLEKECPQLSMYITLESIKQTQYAALSRG 118
            .:|||||||||||||||||             ||::::|:|.|.:::.:.:.|:..|....|||.
Mouse    80 NLILTTGGTGFAPRDVTPEKFPTFPFCGLQKGATKEVIEREAPGMALAMLMGSLNVTPLGMLSRP 144

  Fly   119 LCGIAGNTLILNLPGSEKAVKECFQTISALLPHAVHLIGDDVSLVRKTHAEVQG----------- 172
            :|||.|.|||:|||||:|..:||||.|...||||:.|:.|.:..|::.|.|::.
Mouse   145 VCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPP 209

  Fly   173 --------------------------------SAQKSHICP------------------------ 181
                                            .:..|||..
Mouse   210 PTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAALAAKKHPFYTSPALFMANHGQP 274

  Fly   182 ---------HKTGTG-------------------------TDSD--------------------- 191
                     |.||:.                         |.|:
Mouse   275 IPGLISYSHHATGSADKRIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKQI 339

  Fly   192 ----------------------------------------------------------------- 191
                                                                             
Mouse   340 RRPDESKGVASRVGSLKARLPSCSSTYSVSELHSRLEGLKDELWRNRGYDLRVQSRCSSKENILR 404

  Fly   192 ---------------RNSPYPM-------LPVQEVLSII-FNTVQKTANLNKILL-EMNAPVNIP 232
                           |.||:|:       :.|.|:..:: ...:.....:.::|. ::.|..|:|
Mouse   405 ASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLP 469

  Fly   233 PFRASIKDGYAMKSTGFSGTKRVLGCIAAGDSPNSLPLAEDECYKINTGAPLPLEADCVVQVEDT 297
            ||.||:|||||:::....|.:.::|...||:.|.. .:...:..::.||||:|..||.|||||||
Mouse   470 PFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQ-TVMPGQVMRVTTGAPIPCGADAVVQVEDT 533

  Fly   298 KLLQLDKNGQESL-VDILVEPQAGLDVRPVGYDLSTNDRIFPA---LDPSPVVVKSLLASVG-NR 357
            :|::...:|.|.| |.|||:.:.|.|:||:|:|:...:.:...   :.||.:   .|||:|| ..
Mouse   534 ELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEI---GLLATVGVTE 595

  Fly   358 LILSK-PKVAIVSTGSELCSPRNQLTPGKIFDSNTTMLTELLVYFGFNCMHTCVLSDSFQRTKES 421
            :.::| |.||::|||:||.:|.:.|.||||.|||.:.|...:...|:..::..::.|:......:
Mouse   596 VEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNA 660

  Fly   422 LLELFEVVDFVICSGGVSMGDKDFVKSVLE-DLQFRIHCGRVNIKPGKPMTFASRK----DKYFF 481
            |.|.....|.:|.|||||||:||::|.||: ||..:||.|||.:|||.|.|||:..    .|..|
Mouse   661 LNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIF 725

  Fly   482 GLPGNPVSAFVTFHLFALPAIRFAAGWDRCKCSL----SVLNVKLLNDFSLDSRPEFVRASVISK 542
            .||||||||.||.:||.:||:|...|      .|    :::..:|..|..||.|||:.|..:...
Mouse   726 ALPGNPVSAVVTCNLFVVPALRKMQG------ILDPRPTIIKARLSCDVKLDPRPEYHRCILTWH 784

  Fly   543 SGE--LYASVNGNQISSRLQSIVGADVLINLPARTSDRPLAKAGEIFPASVL 592
            ..|  .:|...|||:||||.|:..|:.|:.||.:|........||:....|:
Mouse   785 HQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVI 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cin	NP_477030.1	MogA_MoaB	4..156	CDD:238451	74/166 (45%)
		MoeA	211..592	CDD:238452	148/398 (37%)
Gphn	XP_006515964.1	MogA_MoaB	15..182	CDD:238451	74/166 (45%)
		MoeA	430..836	CDD:238452	150/415 (36%)