Protein Alignment cin and GPHN

DIOPT Version :10

• Sequence 1: NP_477030.1
• Gene: cin / 30973
• FlyBaseID: FBgn0000316
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: XP_011534642.1
• Gene: GPHN / 10243
• HGNCID: 15465
• Length: 825
• Species: Homo sapiens
• Alignment Length: 818
• Identity: 242/818 - (29%)
• Similarity: 362/818 - (44%)
• Gaps: 239/818 - (29%)

  Fly     4 ITFGVLTISDTCWQEPEKDTSGPILRQLIGE--TFANTQVIGNIVPDEKDIIQQELRKWIDREEL 66
            |..||||:||:|::...:|.||..|:.|:.:  ....|.....|||||.:.|::.|..|.|.:||
Human    15 IRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKEL 79

  Fly    67 RVILTTGGTGFAPRDVTPE-------------ATRQLLEKECPQLSMYITLESIKQTQYAALSRG 118
            .:|||||||||||||||||             ||::::|:|.|.:::.:.:.|:..|....|||.
Human    80 NLILTTGGTGFAPRDVTPEKFPTFPFCGLQKGATKEVIEREAPGMALAMLMGSLNVTPLGMLSRP 144

  Fly   119 LCGIAGNTLILNLPGSEKAVKECFQTISALLPHAVHLIGDDVSLVRKTHAEVQG----------- 172
            :|||.|.|||:|||||:|..:||||.|...||||:.|:.|.:..|::.|.|::.
Human   145 VCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPP 209

  Fly   173 --------------------------------SAQKSHI-------------------------- 179
                                            .:..|||
Human   210 PTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAAIAAKKHPFYTSPAVVMAHGEQP 274

  Fly   180 -------------------------------------------------------CP-------- 181
                                                                   ||
Human   275 IPGLINYSHHSTDERIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKQIRRP 339

  Fly   182 ------------------------HKTG--------------------------TGTD------S 190
                                    |..|                          :..|      .
Human   340 DESKGVASRVGSLKLHRKLEELRDHLEGNVKGYSLRVNVQSRCSSKENILRASHSAVDITKVARR 404

  Fly   191 DRNSPYPM-------LPVQEVLSII-FNTVQKTANLNKILL-EMNAPVNIPPFRASIKDGYAMKS 246
            .|.||:|:       :.|.|:..:: ...:.....:.::|. ::.|..|:|||.||:|||||:::
Human   405 HRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRA 469

  Fly   247 TGFSGTKRVLGCIAAGDSPNSLPLAEDECYKINTGAPLPLEADCVVQVEDTKLLQLDKNGQESL- 310
            ....|.:.::|...||:.|.. .:...:..::.||||:|..||.|||||||:|::...:|.|.|
Human   470 ADGPGDRFIIGESQAGEQPTQ-TVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELE 533

  Fly   311 VDILVEPQAGLDVRPVGYDLSTNDRIFPA---LDPSPVVVKSLLASVG-NRLILSK-PKVAIVST 370
            |.|||:.:.|.|:||:|:|:...:.:...   :.||.:   .|||:|| ..:.::| |.||::||
Human   534 VRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEI---GLLATVGVTEVEVNKFPVVAVMST 595

  Fly   371 GSELCSPRNQLTPGKIFDSNTTMLTELLVYFGFNCMHTCVLSDSFQRTKESLLELFEVVDFVICS 435
            |:||.:|.:.|.||||.|||.:.|...:...|:..::..::.|:......:|.|.....|.:|.|
Human   596 GNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITS 660

  Fly   436 GGVSMGDKDFVKSVLE-DLQFRIHCGRVNIKPGKPMTFASRK----DKYFFGLPGNPVSAFVTFH 495
            ||||||:||::|.||: ||..:||.|||.:|||.|.|||:..    .|..|.||||||||.||.:
Human   661 GGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCN 725

  Fly   496 LFALPAIRFAAGWDRCKCSL----SVLNVKLLNDFSLDSRPEFVRASVISKSGE--LYASVNGNQ 554
            ||.:||:|...|      .|    :::..:|..|..||.|||:.|..:.....|  .:|...|||
Human   726 LFVVPALRKMQG------ILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQ 784

  Fly   555 ISSRLQSIVGADVLINLPARTSDRPLAKAGEIFPASVL 592
            :||||.|:..|:.|:.||.:|........||:....|:
Human   785 MSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVI 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cin	NP_477030.1	MogA_MoaB	4..156	CDD:238451	74/166 (45%)
		MoeA	211..592	CDD:238452	148/398 (37%)
GPHN	XP_011534642.1	MogA_MoaB	15..182	CDD:238451	74/166 (45%)
		MoeA	416..822	CDD:238452	150/415 (36%)