DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and SETDB1

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	NP_001353346.1	Gene:	SETDB1 / 9869	HGNCID:	10761	Length:	1292	Species:	Homo sapiens

Alignment Length:	207	Identity:	62/207 - (29%)
Similarity:	96/207 - (46%)	Gaps:	27/207 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1344 RSFRPLGLRTFVVCADASNGREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQI 1408
            |.|:|  .:.|....|.:.|:|..|:..|          :|.|:...|...|..: .|....|.|
Human   669 RKFQP--YKPFYYILDITYGKEDVPLSCV----------NEIDTTPPPQVAYSKE-RIPGKGVFI 720

  Fly  1409 DRRVSQMRICSCLDSC-SSDRCQCNGASSQ-NWYTAESRLNADFNYED-------PAVIFECNDV 1464
            :.....:..|.|.|.| ...:|.|:..:.| ...|...::|.:..|:.       |..::|||..
Human   721 NTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKR 785

  Fly  1465 CGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADR--- 1526
            |.|:...|.||:||:|.:..||:.  :.|.||||:|.|.::.||:||..|.|:|||...||:
Human   786 CKCDPNMCTNRLVQHGLQVRLQLF--KTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGL 848

  Fly  1527 RTDDSYYFDLDN 1538
            ...|.|:.:||:
Human   849 EMGDEYFANLDH 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375
		Ank_2	1056..1152	CDD:289560
		ANK	1088..1217	CDD:238125
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		Ank_2	1127..1249	CDD:289560
		ANK	1155..1306	CDD:238125
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		Ank_2	1205..1316	CDD:289560
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		PreSET	1357..1466	CDD:128744	26/117 (22%)
		SET	1495..1602	CDD:214614	21/47 (45%)
SETDB1	NP_001353346.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..147
		DUF5604	193..250	CDD:408109
		Tudor_SETDB1_rpt1	260..341	CDD:410453
		Tudor_SETDB1_rpt2	348..401	CDD:410548
		MBD	598..673	CDD:128673	2/3 (67%)
		SET_SETDB1	675..>876	CDD:380915	59/199 (30%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250	814..816		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..1161
		SET	<1203..1292	CDD:394802
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250	1224..1225
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158015
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840