DRSC/TRiP Functional Genomics Resources

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Protein Alignment G9a and KMT2B

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	NP_055542.1	Gene:	KMT2B / 9757	HGNCID:	15840	Length:	2715	Species:	Homo sapiens

Alignment Length:	132	Identity:	41/132 - (31%)
Similarity:	62/132 - (46%)	Gaps:	13/132 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1496 GWGVRALANVPKGTFVGSYTGEILTAMEADRRTD-------DSYYFDLDNGHCIDANYYGNVTRF 1553
            |.|:....|:..|..|..|:|.::.::..|:|..       ..|.|.:|:...:||..:||..||
Human  2586 GRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARF 2650

  Fly  1554 FNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTT 1618
            .|||||||.....:..|.|.:    |..|:.|.|..|||:.:||  ||...:..:.:.|.|....
Human  2651 INHSCEPNCFSRVIHVEGQKH----IVIFALRRILRGEELTYDY--KFPIEDASNKLPCNCGAKR 2709

  Fly  1619 CK 1620
            |:
Human  2710 CR 2711

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375
		Ank_2	1056..1152	CDD:289560
		ANK	1088..1217	CDD:238125
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		Ank_2	1127..1249	CDD:289560
		ANK	1155..1306	CDD:238125
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		Ank_2	1205..1316	CDD:289560
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		PreSET	1357..1466	CDD:128744
		SET	1495..1602	CDD:214614	37/112 (33%)
KMT2B	NP_055542.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
		Menin-binding motif (MBM). /evidence=ECO:0000269\|PubMed:22327296	17..36
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..302
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..518
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..771
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..868
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..959
		zf-CXXC	958..1005	CDD:251032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1027..1132
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1146..1166
		PHD1_KMT2B	1203..1249	CDD:277064
		PHD2_KMT2B	1251..1300	CDD:277066
		PHD3_KMT2B	1337..1393	CDD:277068
		Bromo_ALL-1	1374..1516	CDD:99925
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1545..1567
		ePHD_KMT2B	1581..1685	CDD:277164
		FYRN	1734..1780	CDD:283589
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1806..1978
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2008..2093
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2118..2162
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2280..2412
		FYRC	2413..2497	CDD:197781
		WDR5 interaction motif (WIN). /evidence=ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:22665483	2508..2513
		SET	<2559..2715	CDD:225491	41/132 (31%)
		SET	2577..2697	CDD:214614	38/116 (33%)