DRSC/TRiP Functional Genomics Resources

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Protein Alignment G9a and SETD1A

DIOPT Version :10

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:NP_055527.1 Gene:SETD1A / 9739 HGNCID:29010 Length:1707 Species:Homo sapiens


Alignment Length:1092 Identity:217/1092 - (19%)
Similarity:360/1092 - (32%) Gaps:361/1092 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 AEGGTL---------LNLNLAEDKTLKWRNLANNQ------------FASKEKKHKDKEEEERKE 67
            |||.||         |.:.:.|.|::..|:|....            :.|||:|.|..:...:::
Human   780 AEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQ 844

  Fly    68 ARNQEEIEDIKAL---LADVVDAA-------------------AVKL-----------EEEEAQN 99
            |: :|:.|..|..   |..:||.|                   |::|           |..||..
Human   845 AK-EEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASE 908

  Fly   100 AEKVEPHTKCEIEEEGRKEMEYD--------QDVAKQDSEMEKKQNGKATSITVKMESNERAEKH 156
            .::..|.|..| |:|...|.|.:        ....|:|.|..|.|.....|..:..|..|.:::.
Human   909 EKRPRPSTPAE-EDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQES 972

  Fly   157 ATEIATTSTERWENESFKTE--QQNKKAAE----KEEEPILAATQKL--EANAEPLTTTRIEVAV 213
            ::|......|..|.:..:.|  ...||..|    ::||...::...|  :::.|..:|:..|.: 
Human   973 SSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESS- 1036

  Fly   214 ASPLVVSSASVKLAADATNQMRAATSAGAATLADKNVQVSPGGTRRSRRTPRPIDTPTSVTDEHV 278
                  ||:|...::.:::...:::|:..::..|:..:..|.....:...||.:..||....| |
Human  1037 ------SSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVE-V 1094

  Fly   279 QVENKKFGK-----SEQYTDCSSHLERFTLDDNTAIVRLQLKSEPDKPSLTALSPEENSA----- 333
            .|..:..|.     .||  :.|........:::.....|:....|..|...|..|:|..:     
Human  1095 PVPERVAGSPVTPLPEQ--EASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPL 1157

  Fly   334 -PAPKRGRGRARKIRPDAEVETSEVILPCED-------------SLGEKKP-GRKRKLPDEPIDQ 383
             |.||    :.||....:.:|    ::|..:             ....|.| |.:|.:.:.|:|.
Human  1158 LPPPK----KRRKTVSFSAIE----VVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDH 1214

  Fly   384 QQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGNRLHADGSPWEEVKTEALHPQPSAELSFAEV 448
            ..|     ||:..||        |.|..|| |.|.|    |...||.:.|     |..|:.    
Human  1215 ASL-----VKSWPEE--------VSRGGRS-RAGGR----GRLTEEEEAE-----PGTEVD---- 1252

  Fly   449 TSEILPLAVL-DEKTPPKKRGRKAKTPCVKLESETSCGLPFANGNKKTNSSGGCELQLPKRS--- 509
                  |||| |....|.:||..|              ||....::.|.:|...|...|..|   
Human  1253 ------LAVLADLALTPARRGLPA--------------LPAVEDSEATETSDEAERPRPLLSHIL 1297

  Fly   510 -----KRRIKPTP-----------------------KILENDE-LRCEFETKHIERMTQWESAAA 545
                 ...:||||                       ::||..| :..|.|....:::.|......
Human  1298 LEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGE 1362

  Fly   546 VDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAGTSAIKKRLFSKSQRDIENYGAAML 610
            .:|:.|         ......:.||.|..|:.||         |:::|......|          
Human  1363 EEGEEE---------GEEEEEESSDSSSSSDGEG---------ALRRRSLRSHAR---------- 1399

  Fly   611 AKSKLPPCP------------DVEQ--FLNDIKASRINANRSPEERKLNKKQQRKLAKQ------ 655
             :.:.||.|            :.||  .|.||    .|:....|:....:....:|.:|      
Human  1400 -RRRPPPPPPPPPPRAYEPRSEFEQMTILYDI----WNSGLDSEDMSYLRLTYERLLQQTSGADW 1459

  Fly   656 -KEKHLKH-----LGLQKNHR---DEPSDNDSSNTDNE-FFPTTRVQVGK-----PSVTLRVRNS 705
             .:.|..|     |...|..|   |.|.::.:.:..:| ::|.::.:..|     | |:.|....
Human  1460 LNDTHWVHHTITNLTTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCP-VSARQLEG 1523

  Fly   706 VTKELPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTEAARASVPISTPDAEQLHSLDTSIQADV 770
            |..: .|...|..||:   :..:|...||..|             |...|..:|:.|        
Human  1524 VDTQ-GTNRVLSERRS---EQRRLLSAIGTSA-------------IMDSDLLKLNQL-------- 1563

  Fly   771 TPIRDLDMRPSTSRVSKFICLCQKP-----------------------SQYYARNAPDSSYCCAI 812
             ..|...:|...||:.::.....:|                       .:.|.:....|||...:
Human  1564 -KFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRV 1627

  Fly   813 DH---IDDQKIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGCGIFCTQGKFVLC 874
            ||   ||..|   |..|:..:::...|                    ||.|......:|.|.|: 
Human  1628 DHDTIIDATK---CGNLARFINHCCTP--------------------NCYAKVITIESQKKIVI- 1668

  Fly   875 KQQHFFHPDCAQRFILSTSYEKE-LGDEEDQGVKFSSPVLVLKCP-HCGLDT 924
                               |.|: :|.:|:....:..|:...|.| .||.::
Human  1669 -------------------YSKQPIGVDEEITYDYKFPLEDNKIPCLCGTES 1701

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 PTZ00121 <68..>188 CDD:173412 35/166 (21%)
EHMT_ZBD 786..933 CDD:411018 28/167 (17%)
ANKYR 1063..1322 CDD:440430
ANK repeat 1088..1120 CDD:293786
ANK repeat 1124..1153 CDD:293786
ANK repeat 1155..1196 CDD:293786
ANK repeat 1199..1249 CDD:293786
ANK repeat 1251..1283 CDD:293786
ANK repeat 1285..1316 CDD:293786
SET_EHMT 1391..1622 CDD:380941
SETD1ANP_055527.1 Interaction with WDR82. /evidence=ECO:0000269|PubMed:37030068 60..89
RRM_Set1A 92..186 CDD:409964
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..308
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 331..363
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 381..486
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 506..655
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 834..854 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 891..1251 84/401 (21%)
PRK12323 <1070..>1130 CDD:481241 12/62 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1264..1293 9/42 (21%)
HCFC1-binding motif (HBM) 1299..1303 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1307..1417 24/138 (17%)
Interaction with CFP1 1415..1450 7/38 (18%)
N-SET 1425..1562 CDD:463344 32/158 (20%)
Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269|PubMed:17998332 1450..1537 18/88 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1472..1499 6/26 (23%)
WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483 1492..1497 0/4 (0%)
RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827 1537..1542 1/7 (14%)
SET_SETD1 1556..1703 CDD:380946 35/198 (18%)
Blue background indicates that the domain is not in the aligned region.

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