DRSC/TRiP Functional Genomics Resources

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Protein Alignment G9a and SETDB2

DIOPT Version :9

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:NP_114121.2 Gene:SETDB2 / 83852 HGNCID:20263 Length:719 Species:Homo sapiens


Alignment Length:615 Identity:113/615 - (18%)
Similarity:177/615 - (28%) Gaps:295/615 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly  1267 DTITVLLQSGADCN-------VQNVEGDTPL------HIACRHSVTRMCIALIANGADLMIKNKA 1318
            |:.:.|.....||:       ..|::|:.||      |...||:.|.      ::.:.|.:..| 
Human   135 DSSSNLSYQSHDCSGACLMKMPLNLKGENPLQLPIKCHFQRRHAKTN------SHSSALHVSYK- 192

  Fly  1319 EQLPFDCIPNEESECGRTV-----------------------GFNMQMRSFRPLGLRTFVVC-AD 1359
                        :.|||::                       .||..::..|....:..||. .|
Human   193 ------------TPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYVQLARNYPKQKEVVSDVD 245

  Fly  1360 ASNGREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQIDRRVSQMR-ICSCLDS 1423
            .|||.|:.||...          :|.||...|.|:|  :..:...:..:....|... .|.|.:.
Human   246 ISNGVESVPISFC----------NEIDSRKLPQFKY--RKTVWPRAYNLTNFSSMFTDSCDCSEG 298

  Fly  1424 C-SSDRCQCNGASSQNWYT---AESRLNADFNY-----EDPAVIFECNDVCGCNQLSCKNRVVQN 1479
            | ...:|.|...:::|..|   :..::...:.|     :.|..|:||:.:|.||:..|:|||||:
Human   299 CIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQH 363

  Fly  1480 GTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILT------------------------ 1520
            |.:..||:.:.|.  ||||||.|.::.:||||..|:|.:|:                        
Human   364 GPQVRLQVFKTEQ--KGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDENGRDENTMKNIF 426

  Fly  1521 --------------------AMEADRRT------------------------------------- 1528
                                .:|...||                                     
Human   427 SKKRKLEVACSDCEVEVLPLGLETHPRTAKTEKCPPKFSNNPKELTVETKYDNISRIQYHSVIRD 491

  Fly  1529 ----------------------------------------------------------------- 1528
                                                                             
Human   492 PESKTAIFQHNGKKMEFVSSESVTPEDNDGFKPPREHLNSKTKGAQKDSSSNHVDEFEDNLLIES 556

  Fly  1529 ----------------------------------------------------------------- 1528
                                                                             
Human   557 DVIDITKYREETPPRSRCNQATTLDNQNIKKAIEVQIQKPQEGRSTACQRQQVFCDEELLSETKN 621

  Fly  1529 ---DDSYYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAG 1590
               |....|:..|...:||...|||.||.||||.||:|...||.|..:..||.:|||:.|.:.|.
Human   622 TSSDSLTKFNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKAR 686

  Fly  1591 EEICFDYGEKFWRVEHRSCVGCRCLTTTCK 1620
            .|:.:|||.:...|..:. :.|:|....|:
Human   687 TELTWDYGYEAGTVPEKE-IFCQCGVNKCR 715

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 ATP-synt_B 150..248 CDD:304375
Ank_2 1056..1152 CDD:289560
ANK 1088..1217 CDD:238125
ANK repeat 1088..1120 CDD:293786
ANK repeat 1124..1153 CDD:293786
Ank_2 1127..1249 CDD:289560
ANK 1155..1306 CDD:238125 12/51 (24%)
ANK repeat 1155..1196 CDD:293786
ANK repeat 1199..1249 CDD:293786
Ank_2 1205..1316 CDD:289560 13/61 (21%)
ANK repeat 1251..1283 CDD:293786 4/22 (18%)
ANK repeat 1285..1316 CDD:293786 8/36 (22%)
PreSET 1357..1466 CDD:128744 26/119 (22%)
SET 1495..1602 CDD:214614 48/320 (15%)
SETDB2NP_114121.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..102
HMT_MBD 164..224 CDD:238689 11/78 (14%)
Pre-SET 246..359 CDD:282838 29/124 (23%)
SET 367..>428 CDD:214614 17/62 (27%)
S-adenosyl-L-methionine binding. /evidence=ECO:0000250 377..379 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 508..547 0/38 (0%)
SET <630..696 CDD:214614 30/65 (46%)