DRSC/TRiP Functional Genomics Resources

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Protein Alignment G9a and KMT2D

DIOPT Version :9

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:XP_011537072.1 Gene:KMT2D / 8085 HGNCID:7133 Length:5556 Species:Homo sapiens


Alignment Length:1985 Identity:341/1985 - (17%)
Similarity:592/1985 - (29%) Gaps:715/1985 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 KEEEERKEARNQEEIEDIKALLADVVD-AAAVKLEEEEAQNAEKVEPHTKC----EIEEEGRKEM 119
            ::::::::.:.|..:..:..|...::. :...||..:...:.::::...:.    :::::.::::
Human  3859 QQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQL 3923

  Fly   120 EYDQDVAKQDSEMEKKQNGKATSITVKMESNERAEKHATEIATTSTERWENESFKTEQQNKKAAE 184
            :..|.:.:|..:.:::|.        :::..::.:....:......::.:.:.|:.:||.::...
Human  3924 QQQQQLQQQQLQQQQQQQ--------QLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGL 3980

  Fly   185 KEEEPILAATQKLEAN---------AEPL------------------TTTRIEVAVAS------- 215
            ..:...|.:.|:.:..         |:||                  ....::.||:|       
Human  3981 LNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGPS 4045

  Fly   216 -----PLVVSSASVKLAADATNQMRAATSAGAATLADKNVQVSPGGTRRSRRTPRPIDTPTSVTD 275
                 ||.:.:....:|.: ..:::.:.|..:..|.   ||..|.....|.:...|:..| ....
Human  4046 THQGGPLAIGTTPESMATE-PGEVKPSLSGDSQLLL---VQPQPQPQPSSLQLQPPLRLP-GQQQ 4105

  Fly   276 EHVQVENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQLKSEPDKPSLTALSPEENSAPAPKRGR 340
            :.|.:.:...|.|.......|..|..::....|...:.|..:|...:...|.|::.....|.:..
Human  4106 QQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNN 4170

  Fly   341 GRARKIRPDAEVETSE-----VILPCEDSLGEKKPGRKRKLPD----EPIDQQQLSDLVVVKTEQ 396
            ...:..:|...:::.:     .|:|....|..:..|...|.|.    .|..||||..|::.:..|
Human  4171 TGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQ 4235

  Fly   397 E----------------------------ELGDAP---------LGDVKRMRRSVRLGNRLHADG 424
            :                            :||..|         ||...|.:...||        
Human  4236 QSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRL-------- 4292

  Fly   425 SPWEEVKTEALHPQPSAELSFAEVTSEILPLAVLDEKTPP------KKRGRKAKTPCVKLESE-- 481
                        |.|...||...|...:.|       |||      .||..:..:|..:|.:|  
Human  4293 ------------PAPPGALSTGPVLGPVHP-------TPPPSSPQEPKRPSQLPSPSSQLPTEAQ 4338

  Fly   482 ---TSCGLP-------------------------FANG-------------NKKTNSS---GGCE 502
               |..|.|                         |:.|             .|...||   |..:
Human  4339 LPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSLVPGHLD 4403

  Fly   503 ----LQLPKRSKRRIKPTPKILENDELRCEFETKHIERMTQWESAAA------------------ 545
                ..:|:.|:..||..|:     |..|....:.::|....|...|                  
Human  4404 QVNGQVVPEASQLSIKQEPR-----EEPCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGH 4463

  Fly   546 --------------------------VDGDFETPTTG------GNGSNSS--------------- 563
                                      ::|..::...|      |..||..               
Human  4464 LLLQKLLRAKNVQLSTGRGSEGLRAEINGHIDSKLAGLEQKLQGTPSNKEDAAARKPLTPKPKRV 4528

  Fly   564 --------TSRQKSDKSDG--------------------------SNFE----GGPGHPA-GTSA 589
                    :||:|..|.||                          :||.    .|.|.|. |.|.
Human  4529 QKASDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLPLTEPAITANFSLFAPFGSGCPVNGQSQ 4593

  Fly   590 IKKRLFSKSQRDIENYGAAMLAK----------SKLPPC--PDVEQ-FLNDIKASRINANRSPEE 641
            ::....|.:.....:|.:.:|.|          |.|||.  |.|:| .:|.:..|. .....|::
Human  4594 LRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTPSE-ELGEHPKD 4657

  Fly   642 RKLNKKQQRKLAKQKEKHLKHLGL-------QKNHRDE---PSDNDSSNTDNEFFPTTRVQVGKP 696
            ....:..:|.|....|  :|.|.|       ..|..::   .||.||.:      |.:.|....|
Human  4658 AASARDSERALRDTSE--VKSLDLLAALPTPPHNQTEDVRMESDEDSDS------PDSIVPASSP 4714

  Fly   697 SVTLRVRNSVTKELPTTATLKSRR--------NPVVQAAKLTRRIGARAAGEVTEAARASVPIST 753
            ...|      .:|.|....|.|.|        :||:..                 ..|||:|: .
Human  4715 ESIL------GEEAPRFPHLGSGRWEQEDRALSPVIPL-----------------IPRASIPV-F 4755

  Fly   754 PDAEQLHSLDTSIQADVTPIRDLDMRPSTSRVSKFICLCQKPSQYYARNAPDSSYCCAIDHIDDQ 818
            ||.:...:|...:...: |:...: :...|.||..:.:.                ..|..:::..
Human  4756 PDTKPYGALGLEVPGKL-PVTTWE-KGKGSEVSVMLTVS----------------AAAAKNLNGV 4802

  Fly   819 KIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGCGIFCTQGKFVLCKQQHFFHPD 883
            .:.....||.::.|        ||.:|..|...|       ||.                     
Human  4803 MVAVAELLSMKIPN--------SYEVLFPESPAR-------AGT--------------------- 4831

  Fly   884 CAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLDTPERTSTV----TMKCQSLPVFLRT 944
                       |.:.|:.|..|.|...  |..|.|..|.|..::...|    |:|.|...:.|..
Human  4832 -----------EPKKGEAEGPGGKEKG--LEGKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLK 4883

  Fly   945 QKYKIKPARLTTSSHLTQFGTVENANT--------------PGATARNKGGLST----------- 984
            |:   .||....:.|...: .|.|.:.              |...|.:.....|           
Human  4884 QE---SPAPEPPTQHSYTY-NVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPL 4944

  Fly   985 -----AVTLSAASSPASKTNGAQRGRAGTSNSNSR----HALNSINFAQLIPESVMNVVLRGHVV 1040
                 ...|..||||.| .....|.|......:||    .....:.:.:|   .::..:.:|...
Human  4945 AEPPVPSPLPLASSPES-ARPKPRARPPEEGEDSRPPRLKKWKGVRWKRL---RLLLTIQKGSGR 5005

  Fly  1041 SASGRVTAEF------------TPRDM---YYAVQNDD--LERVAEILAADFNV---------LT 1079
            ....|..|||            .||||   .:..:..|  .:..|.:|..|.::         .|
Human  5006 QEDEREVAEFMEQLGTALRPDKVPRDMRRCCFCHEEGDGATDGPARLLNLDLDLWVHLNCALWST 5070

  Fly  1080 PIREYLNGTCLH--LVAHSGTLQMAYLLLCKGASS-------PDFVNIVDYELRTALMCAVMNEK 1135
            .:.|...|..::  :..|.|.|....|....||:|       |   |:..:.......|....:|
Human  5071 EVYETQGGALMNVEVALHRGLLTKCSLCQRTGATSSCNRMRCP---NVYHFACAIRAKCMFFKDK 5132

  Fly  1136 ---CDMLNLFLQCG----------------------ADVAIKG--------------------PD 1155
               |.|..:...|.                      |.:..:|                    |.
Human  5133 TMLCPMHKIKGPCEQELSSFAVFRRVYIERDEVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPH 5197

  Fly  1156 GKTSLHIAAQL--GNLEATQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLA 1218
            .....|.|..|  ...|||: |..|.||:.....:...| .::.|....::...|.|..|:|...
Human  5198 QMADFHSATALYPVGYEATR-IYWSLRTNNRRCCYRCSI-GENNGRPEFVIKVIEQGLEDLVFTD 5260

  Fly  1219 SLPQAVFLKLIN-----------IFLFISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVL 1272
            :.||||:.::|.           :.||..:|..::                       |..:|| 
Human  5261 ASPQAVWNRIIEPVAAMRKEADMLRLFPEYLKGEE-----------------------LFGLTV- 5301

  Fly  1273 LQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQLP-FDCIPNEESECGRT 1336
                                   |:|.|:                ||.|| .:...|.....||.
Human  5302 -----------------------HAVLRI----------------AESLPGVESCQNYLFRYGRH 5327

  Fly  1337 VGFNMQMRSFRPLGLRTFVVCADASNGREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCII 1401
            ....:.: ...|.|      ||.:    |.:.:...:.......:.|..::||.|.         
Human  5328 PLMELPL-MINPTG------CARS----EPKILTHYKRVFTSIISFDPHNNLMRPH--------- 5372

  Fly  1402 QQNSVQIDRRVSQMRICSCLDSCSSDRCQCNGASSQNWYTAES----RLNADFNYEDPAVIFECN 1462
            ..||..:.:...           |:...:.|...|:.:..::|    ||..::            
Human  5373 TLNSTSMSKAYQ-----------STFTGETNTPYSKQFVHSKSSQYRRLRTEW------------ 5414

  Fly  1463 DVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRR 1527
                      ||.|....:|           .:|.|:.|..::.|.|.|..|.|.|:....|:||
Human  5415 ----------KNNVYLARSR-----------IQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRR 5458

  Fly  1528 -------TDDSYYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCR 1585
                   ....|.|.::|.|.|||...|...|:.||||.||.:...|.::.:|    ||...|.|
Human  5459 EKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKED----KIIIISSR 5519

  Fly  1586 DIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTTCK 1620
            .|..|||:.:||...|...:|:  :.|.|....|:
Human  5520 RIPKGEELTYDYQFDFEDDQHK--IPCHCGAWNCR 5552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 ATP-synt_B 150..248 CDD:304375 16/136 (12%)
Ank_2 1056..1152 CDD:289560 22/140 (16%)
ANK 1088..1217 CDD:238125 33/184 (18%)
ANK repeat 1088..1120 CDD:293786 9/40 (23%)
ANK repeat 1124..1153 CDD:293786 6/53 (11%)
Ank_2 1127..1249 CDD:289560 32/179 (18%)
ANK 1155..1306 CDD:238125 30/163 (18%)
ANK repeat 1155..1196 CDD:293786 11/42 (26%)
ANK repeat 1199..1249 CDD:293786 12/60 (20%)
Ank_2 1205..1316 CDD:289560 18/121 (15%)
ANK repeat 1251..1283 CDD:293786 3/31 (10%)
ANK repeat 1285..1316 CDD:293786 3/30 (10%)
PreSET 1357..1466 CDD:128744 15/112 (13%)
SET 1495..1602 CDD:214614 39/113 (35%)
KMT2DXP_011537072.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157994
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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