DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and setbp1

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	XP_005165732.1	Gene:	setbp1 / 796785	ZFINID:	ZDB-GENE-060526-72	Length:	1438	Species:	Danio rerio

Alignment Length:	1313	Identity:	250/1313 - (19%)
Similarity:	413/1313 - (31%)	Gaps:	450/1313 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FVELMNSMS------STFNSDCATSTAEGGTLLNLNLAEDKTLKWRNLANNQFASKEKKHKDKEE 62
            |...|:|.|      |:.|:..:.||  ..:|.:.|  :|:.|  :.:....|.:.::|:..|:.
Zfish   250 FGSTMSSPSTDLLAASSVNTVMSPST--DSSLFSFN--KDRGL--QQVTEQVFGNIKRKYGRKDP 308

  Fly    63 EERKEARNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEPHTKCEIEEEGRKEMEYDQDVAK 127
            .:.....|              :|...||..:.:.:|            ::..:::..|.||.:.
Zfish   309 TKTPVMHN--------------LDLQWVKKMDRDTEN------------QDSAKEKQPYSQDKSA 347

  Fly   128 QDSEMEKKQN----------GKATSITVKMESNERAEKHATEIATTSTERWENESFKTEQQNKKA 182
            .:.|.||..|          |..|..|.:..|.:|..:..||.:..|..:...:..||:..::..
Zfish   348 FEEEPEKPINRLDDDNKTTTGCGTHYTEESRSKKRRNRKVTEDSMVSNAQTVQQDEKTDNTDQGC 412

  Fly   183 AEKEEEPILAATQKLEANAEP-----LTTTRIEVAVASPLVVSSASVKLAADATNQMRAATSAGA 242
            .:      |..|:|.:.||..     |..::.::                        |.|....
Zfish   413 TK------LKVTKKTDVNAPKQFGFNLQQSKEDI------------------------AGTVTDD 447

  Fly   243 ATLADKNVQVSPGGTRRSRRTPRPIDTPTSVTDEHVQVENKKFGKSEQYTDCSSHLERFTLDDNT 307
            |.:.....:.:|.|..||.                :.|:.:..|:..:..|      |:
Zfish   448 AEMFQNRPRKTPAGRARSM----------------IDVDKQTEGRQSKVKD------RW------ 484

  Fly   308 AIVRLQLKSE---PDKPSLTALSPEENSAPAPKRGRGRARKIRPDAEVETS----EVILPCEDSL 365
                |.|||:   |.|....:||.||..:..|         |.|.:.:.|:    .||.|.
Zfish   485 ----LYLKSQNSSPHKDLNQSLSIEEPPSAFP---------ITPSSPLYTNTNSLTVITPV---- 532

  Fly   366 GEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQEELGDAPLGDV--------KR----MRRSVRLGN 418
             :||.||.:|.|           |:.|:|..|....:|:..:        ||    |.:.|:|
Zfish   533 -KKKRGRPKKQP-----------LLTVETIHEGTATSPVSPIAHDSSNTSKRKKHNMSKLVQL-- 583

  Fly   419 RLHADGSPWEEVKTEALHPQPSA-ELSFAEVTSEILPLAVLDEKTPPKKRGRKAKTPCVKLESET 482
                           |.|..|.| :|...:...|    .||.::||.|.:..|.:....:|.|.:
Zfish   584 ---------------AFHKSPPAQQLQLKKSDQE----GVLKKRTPTKIKEVKMQNIINELLSTS 629

  Fly   483 SCG-------LPFANGNKKTNSS----GGCELQLPKR------SKRRIKPTPKILENDELRCEFE 530
            |.|       :|.:|......|:    .|.::.:.||      .||..||          |.:..
Zfish   630 SSGNLAPKPNVPVSNAMSTVASTIEARFGKQINVSKRGTIYIGKKRGRKP----------RADLS 684

  Fly   531 TKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDK----SDGSNFEGGPGHPAGTSAIK 591
            ::..|.....:.:......||.|..  ..|||||:...|.:    ....:..||..||..|..
Zfish   685 SQQDEHKASDKHSLLNSSPFENPLV--PSSNSSTTGMPSPRVMHSFSSHSAPGGAAHPVTTDT-- 745

  Fly   592 KRLFSKSQRDIENYGAAMLAKSKLPPCPDVEQFLNDIKASRINAN--RSPEERKLNKKQQ-RKLA 653
                  ||.|::.          :|....:...........:::|  .||.....|.... .::|
Zfish   746 ------SQHDLKT----------MPNLQPISALPTKTHKGLLSSNWKLSPPRLMANSPSHLSEVA 794

  Fly   654 KQKEKHLKHLGLQKNHRDE--PS------DNDSSNTDNEFFPTTRVQVG---------------- 694
            ..||..|.  .:.::|.:|  ||      ||:|::...|..|.:|.:..
Zfish   795 SIKEVTLS--PVSESHSEETIPSDSGIGTDNNSTSDQTEKGPASRRRYSFDLCSFDATEAAIIDA 857

  Fly   695 ----------KPSVTLRVRNSVTKELPTTATLKS----RRNPVVQA-------AKLTR------- 731
                      |....:.|.|...:|     .||.    |:...:|:       |.|..
Zfish   858 KSKAARGHYQKHVTAVSVENFFAQE-----NLKKQKHRRKRKALQSQDDLQFMADLEELVSKFQV 917

  Fly   732 -RIGARAAGEVTEAARASV---------PISTPDAEQLHSLDTSIQADVTPIRDLDMRPSTSRVS 786
             ||..|......|.:..|:         |:.....:.||.|..|  :|.:..|......|...:|
Zfish   918 FRISHRNYKFYHENSYPSIFRLNFDHYYPMPYYPYDPLHYLRRS--SDKSKRRRGRPAKSDEPIS 980

  Fly   787 KFICL----CQKP-SQYYARNA-PDSSYCCAIDHIDDQKIG-------CCNELSSEVHNLLRP-- 836
            |...:    |..| ..|||..| |.:|...|...|:....|       ..:.|......|:||
Zfish   981 KMPFIQGFGCPVPGGNYYAPYAMPYTSMPLATSMINMGYYGQYPSPLYLSHALGPTASPLMRPPV 1045

  Fly   837 -----------------SQRVSYMILCDEHKKRLQSHNCCAGCGIFCTQGKFVLCKQQH---FFH 881
                             ..||..|.......:...||:..:.|     .|...|.|::|   :.|
Zfish  1046 PPPKFHPGASSCLSASSRHRVKNMPHEMSSSRMSDSHHPSSSC-----LGSVCLHKRKHKHKYKH 1105

  Fly   882 PDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLDTPERTSTVTMKCQSLPVFLRTQK 946
            .:           ::.:.:.||.|..||           |..:|...|.:..:.:      :...
Zfish  1106 KE-----------DQYIQEREDLGGLFS-----------GTQSPAFLSLLNERLE------KNSL 1142

  Fly   947 YKIKPARLTTSSHLTQFGTVENANTPGATARNKGGLSTAVTLSAASSPASKTNGAQRGRAGTSNS 1011
            .|:|..:  ...|.|        :|....:||...:.|..:||.:.|...|     |.|..|.|
Zfish  1143 SKLKDKQ--RGKHST--------DTSPKASRNYFEVDTLSSLSLSDSQHCK-----RTRGETLN- 1191

  Fly  1012 NSRHALNSINFAQLIPESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQNDDLERVAEILAADFN 1076
                     ||        :|:..|              .|.:...|.|:..|:...
Zfish  1192 ---------NF--------LNICTR--------------QPHERLRASQDQPLDLFK-------- 1217

  Fly  1077 VLTPIREYLNG--TCLHLVAHS----GTLQMAYLLLCKGAS----------SPDFVNIVDYELRT 1125
                 .::|.|  :.:|:..||    .|.:...:...:|.|          |........|:.|.
Zfish  1218 -----GQHLGGDDSSIHIRRHSLEDFTTYKEGSMASFQGCSEERAEQMYQCSTAVAEPSSYKRRP 1277

  Fly  1126 ALMCAVMNEKCDM 1138
            .|:..|...:|||
Zfish  1278 KLVEEVEEVQCDM 1290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	15/102 (15%)
		Ank_2	1056..1152	CDD:289560	19/99 (19%)
		ANK	1088..1217	CDD:238125	14/65 (22%)
		ANK repeat	1088..1120	CDD:293786	7/45 (16%)
		ANK repeat	1124..1153	CDD:293786	6/15 (40%)
		Ank_2	1127..1249	CDD:289560	5/12 (42%)
		ANK	1155..1306	CDD:238125
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		Ank_2	1205..1316	CDD:289560
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		PreSET	1357..1466	CDD:128744
		SET	1495..1602	CDD:214614
setbp1	XP_005165732.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593902
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930