Protein Alignment G9a and ezh2

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: NP_001070747.1
• Gene: ezh2 / 768133
• ZFINID: ZDB-GENE-041111-259
• Length: 760
• Species: Danio rerio
• Alignment Length: 220
• Identity: 67/220 - (30%)
• Similarity: 94/220 - (42%)
• Gaps: 50/220 - (22%)

  Fly  1399 CIIQQNSVQIDRRVS---QMRI--CSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVI 1458
            |:..||..:...:.|   |.|.  |.|...|::.:|.|        |.|               :
Zfish   550 CVTAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPC--------YLA---------------V 591

  Fly  1459 FECN-DVC---------GCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGS 1513
            .||: |:|         ....:||||..:|.|.:..|.:...:  ..|||:.....|.|..|:..
Zfish   592 RECDPDLCLTCGAAEHWDSKNVSCKNCSIQRGAKKHLLLAPSD--VAGWGIFIKEPVQKNEFISE 654

  Fly  1514 YTGEILTAMEADRRTD------DSYYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQ 1572
            |.|||::..|||||..      .|:.|:|:|...:||...||..||.|||..||.. .:|...:.
Zfish   655 YCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCY-AKVMMVNG 718

  Fly  1573 DYRFPKIAFFSCRDIDAGEEICFDY 1597
            |:|   |..|:.|.|..|||:.|||
Zfish   719 DHR---IGIFAKRAIQTGEELFFDY 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412
		EHMT_ZBD	786..933	CDD:411018
		ANKYR	1063..1322	CDD:440430
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		SET_EHMT	1391..1622	CDD:380941	67/220 (30%)
ezh2	NP_001070747.1	EZH2_WD-Binding	39..68	CDD:463308
		PRC2_HTH_1	159..262	CDD:436286
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..231
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..444
		preSET_CXC	573..604	CDD:408079	11/53 (21%)
		SET_EZH2	623..742	CDD:380995	45/124 (36%)