DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment G9a and Kmt2b

DIOPT Version :9

Sequence 1:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	NP_001277502.1	Gene:	Kmt2b / 75410	MGIID:	109565	Length:	2722	Species:	Mus musculus

Alignment Length:	1114	Identity:	219/1114 - (19%)
Similarity:	371/1114 - (33%)	Gaps:	340/1114 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 QFASKEKK----------------------------HKDKEEEERKEARNQEEIEDIKALLADVV 85
            :|.||.||                            .||.:|.||...|.::|
Mouse   306 KFVSKAKKVKMGQLSQELESGQGHGQRGESWQDAPQRKDGDEPERGSCRKKQE------------ 358

  Fly    86 DAAAVKLEEEEAQNAEKVEPHTKCEIEEEGRK---EMEYDQDVAKQDSEMEK-KQNGKATS--IT 144
                .||||||.:..::.|...:.:..|:..|   |.|.::.||::::.:.| |:..|..|  :|
Mouse   359 ----QKLEEEEEEEEKEGEEKEEKDDNEDNNKQEEEEETERAVAEEEAMLAKEKEEAKLPSPPLT 419

  Fly   145 VKMES------------------------------------NERAEKHATEI-ATTSTERWENES 172
            ..:.|                                    .|:.|:....: ||.|.:|.....
Mouse   420 PPVPSPPPPLPPPSTSPPPPASPLPPPVSPPPPLSPPPYPAPEKQEESPPLVPATCSRKRGRPPL 484

  Fly   173 FKTEQQNKKAAEKEEEPILAATQKLEANAEPLTTTRIEVAVASPLVVSSASVKLAADATNQMRAA 237
            ..:::..::||....|..|:.|      ..|.|||...:. .||.||..::..|
Mouse   485 TPSQRAEREAARSGPEGTLSPT------PNPSTTTGSPLE-DSPTVVPKSTTFL----------- 531

  Fly   238 TSAGAATLADKNVQ--VSPGGTRRSRR---TPR--------------------PIDTPTSVTDEH 277
                      ||::  :.|..:.||.|   |||                    |:.|......|.
Mouse   532 ----------KNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEASIVRPPVATSPPAPQEP 586

  Fly   278 VQVENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQLKSE-PDKPSLTALSPEENSAPAPKRGRG 341
            |.|.:.....:...|......:|.::..........|..| |..|.....:|....|||....|.
Mouse   587 VPVSSPPRVPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPAPSPPPAPATPSRRP 651

  Fly   342 ---RARKIRP-DAEVETSEVIL----------------PCEDSLGEKKP---GRKRKLPDEPIDQ 383
               ||.:..| :|.::..|.:|                |.:||..|.:|   ||...|
Mouse   652 LLLRAPQFTPSEAHLKIYESVLTPPPLGALETPEPELPPADDSPAEPEPRAVGRTNHL------- 709

  Fly   384 QQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRLGNRLHADGSPWEEVKT----EALHP-QPSAE- 442
             .|...|.|.|...::...|.|     ..::..|.:|.....| :.::|    :||.| ||.|:
Mouse   710 -SLPRFVPVVTSPVKVEVPPHG-----APALSEGQQLQLQQPP-QALQTQLLPQALPPQQPQAQP 767

  Fly   443 ---------LSFAEVTS-EILPLAVLDEKTPPKKRGRKAKTPCVKLESE----TSCGLPF----- 488
                     |..|.|.| ..|||:.::||.  ....::||....|::.:    .:..:|.
Mouse   768 PPSPQHTPPLEKARVASLGSLPLSGVEEKM--FSLLKRAKVQLFKIDQQQQQKVAASMPLSPAVQ 830

  Fly   489 ---ANGNKKTNSSGGC-----ELQLPKRSKRRIKPTPKILENDELRCEFETKHIER---MTQWES 542
               |.|..|.....||     |....||.:.....:|  |:...:      ||:.|   :...::
Mouse   831 TEEAVGTVKQTPDRGCVRSEDESMEAKRDRASGPESP--LQGPRI------KHVCRHAAVALGQA 887

  Fly   543 AAAVDGDF---------------ETPTTGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAGTSAIKK 592
            .|.|..|.               ...|:..:.:.|..||.:.:|.:.:. .||...|.|::.
Mouse   888 RAMVPEDVPRLSALPLRDRQDLATEDTSSASETESVPSRSQREKVESAG-PGGDSEPTGSTG--- 948

  Fly   593 RLFSKSQRDIENYGAAMLAKSKLPPC------PDVEQFLNDIKASRINANRSPEE----RKLNKK 647
            .|....:|.:.::....:..::...|      .|....:|.:...:.....:.::    ||.:|.
Mouse   949 ALAHTPRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKKQCCVYRKCDKI 1013

  Fly   648 QQRK---LAKQKEKHLKHLGLQKNHRDEPSDNDSSNTDNEFFPTTRVQVGKPSVTLRVRNSVTKE 709
            :.||   |||:....:|.|        .|.|:|.|...:...|..|...|        .....:|
Mouse  1014 EARKMERLAKKGRTIVKTL--------LPWDSDESPEASPGPPGPRRGAG--------AGGSREE 1062

  Fly   710 LPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTEAARASVP-------ISTPDAEQLHSLDTSIQ 767
            :..|...:.:.:.::|.....|.:..|.:.:|.|.:..|.|       ..||...:|..|:...|
Mouse  1063 VGATPGPEEQDSLLLQRKSARRCVKQRPSYDVFEDSDDSEPGGPPAPRRRTPREHELPVLEPEEQ 1127

  Fly   768 A-----DVTPIRDLDMRPSTSRVSKFICLCQKPSQYY------ARNAPDSSYCCAIDHIDDQKI- 820
            :     .:.|:..|..|   .|:.| ..|...|...:      .:.:||..:...:|..:|..:
Mouse  1128 SRPRKPTLQPVLQLKAR---RRLDK-DALAPGPFASFPNGWTGKQKSPDGVHRVRVDFKEDCDLE 1188

  Fly   821 -----GCCNELSS-----EVHNLLRPSQRVSYMILC------------DEHKKRLQSHN---CCA 860
                 |..:.|:|     .:..||..|:.:..::.|            :|.::....|.   ||.
Mouse  1189 NVWLMGGLSVLTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPSPQHRDTWCCR 1253

  Fly   861 GCGIFC----TQGK----FVLCKQ-QHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLK 916
            .|. ||    .:|:    .:.|:: :|.:||.|     |..||...........:..:    .::
Mouse  1254 RCK-FCHVCGRKGRGSKHLLECERCRHAYHPAC-----LGPSYPTRATRRRRHWICSA----CVR 1308

  Fly   917 CPHCGLDTP 925
            |..||. ||
Mouse  1309 CKSCGA-TP 1316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	20/98 (20%)
		Ank_2	1056..1152	CDD:289560
		ANK	1088..1217	CDD:238125
		ANK repeat	1088..1120	CDD:293786
		ANK repeat	1124..1153	CDD:293786
		Ank_2	1127..1249	CDD:289560
		ANK	1155..1306	CDD:238125
		ANK repeat	1155..1196	CDD:293786
		ANK repeat	1199..1249	CDD:293786
		Ank_2	1205..1316	CDD:289560
		ANK repeat	1251..1283	CDD:293786
		ANK repeat	1285..1316	CDD:293786
		PreSET	1357..1466	CDD:128744
		SET	1495..1602	CDD:214614
Kmt2b	NP_001277502.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
		Menin-binding motif (MBM). /evidence=ECO:0000250\|UniProtKB:Q9UMN6	17..36
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..524		48/240 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..783		54/254 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	831..872		10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..964		11/68 (16%)
		zf-CXXC	963..1010	CDD:251032	4/46 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1076		10/59 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1088..1138		10/49 (20%)
		PHD1_KMT2B	1209..1255	CDD:277064	8/45 (18%)
		PHD2_KMT2B	1257..1306	CDD:277066	11/57 (19%)
		PHD3_KMT2B	1343..1399	CDD:277068
		Bromo_ALL-1	1380..1522	CDD:99925
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1550..1572
		ePHD_KMT2B	1587..1691	CDD:277164
		FYRN	1740..1786	CDD:283589
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2065..2113
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2125..2169
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2288..2365
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2391..2417
		FYRC	2420..2504	CDD:197781
		WDR5 interaction motif (WIN). /evidence=ECO:0000250\|UniProtKB:Q9UMN6	2515..2520
		SET	<2566..2722	CDD:225491
		SET	2584..2704	CDD:214614
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q03164	2659..2660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930