Protein Alignment G9a and NSD2

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: NP_001427822.1
• Gene: NSD2 / 7468
• HGNCID: 12766
• Length: 1398
• Species: Homo sapiens
• Alignment Length: 1738
• Identity: 317/1738 - (18%)
• Similarity: 527/1738 - (30%)
• Gaps: 710/1738 - (40%)

  Fly   127 KQDSEMEKKQNGKATSITVKMESNERAEKHATEIATTSTERWENESF------------KTEQQN 179
            ||..|:....|||..|..|..|.:....|..   .::|.:....:.|            |.:...
Human    22 KQAPEILGSANGKTPSCEVNRECSVFLSKAQ---LSSSLQEGVMQKFNGHDALPFIPADKLKDLT 83

  Fly   180 KKAAEKE----EEPILAATQKLEANAEPLTTTRIEVAVASPLVVSSASVKLAADAT--------N 232
            .:....|    :..:...:|:::....|..||        |:...|..:||....|        .
Human    84 SRVFNGEPGAHDAKLRFESQEMKGIGTPPNTT--------PIKNGSPEIKLKITKTYMNGKPLFE 140

  Fly   233 QMRAATSAGAATLADKNVQVSPGGTRRSRRTP-----------------RPIDTPT--------- 271
            ......||...:.:::|.|......||:|:..                 ..|.:|:
Human   141 SSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKVFRRRC 205

  Fly   272 -----SVTDEH---VQVENKKFGKSEQY----TDC------SSHLERFTLDDNTAIVRLQLKSEP 318
                 :::.||   ::...:..|::|:.    ..|      ..||.::.:.|   :|..::...|
Human   206 VRGHVTLSSEHGHPMRAPARVLGRAEKIPAKKESCPNTGRDKDHLLKYNVGD---LVWSKVSGYP 267

  Fly   319 DKP----------SLTALSPEENSA---------PAPKR------------GRGRARKIRPDAEV 352
            ..|          |.|.|..::.||         .||:|            |.|:..|:
Human   268 WWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKL------ 326

  Fly   353 ETSEVILPCEDSLGEKKPGRKRKLP-DEPIDQQQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRL 416
                    |::| .::.|.:..|:. .:||..:..:...:...:.||.....:.:.|.....:.:
Human   327 --------CQES-AKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYV 382

  Fly   417 GNRLHADGSPWEEVKTEALHPQPSAELSFAE-----------VTSEIL--PLAVLDEKTPPKKRG 468
            |::||             |:||.:.|...|.           |:.|..  |.:|.:|..|.|:|
Human   383 GDQLH-------------LNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRR- 433

  Fly   469 RKAK--TPCVKLESETSCGLPFANGNKKTNSSGGCELQLPKRSKRRIKPTP-KILENDELRCEFE 530
            |:||  :....|||....|                            |.|| |..|.|..|
Human   434 RRAKLCSSAETLESHPDIG----------------------------KSTPQKTAEADPRR---- 466

  Fly   531 TKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAGTSAIKKRLF 595
                                        |..|...|:|:..|       .|....|.:|.:..:|
Human   467 ----------------------------GVGSPPGRKKTTVS-------MPRSRKGDAASQFLVF 496

  Fly   596 SKSQRDIENYGAAMLAKSKLPPCPDVEQFLNDIKASRINANRSPEERKLNKKQQRKLAKQKEKHL 660
            .:..||      .::|:.......::|:.|.    |:.:.....:..:.|.|.......|.|:..
Human   497 CQKHRD------EVVAEHPDASGEEIEELLR----SQWSLLSEKQRARYNTKFALVAPVQAEEDS 551

  Fly   661 KHL-GLQKNH----RDEPSDNDSSNTDNEFFPTTRVQVGKPSVTLRVRNSVT---------KELP 711
            .:: |.::||    :|...|.::.:|     |..|::..|.|  ||.|:::|         |.:.
Human   552 GNVNGKKRNHTKRIQDPTEDAEAEDT-----PRKRLRTDKHS--LRKRDTITDKTARTSSYKAME 609

  Fly   712 TTATLKS---------------RRNPVVQAAKLTRRIG----ARAAGEVTEAARASVPISTPDAE 757
            ..::|||               :||....||  :..:|    :..:..:||...:..|...|...
Human   610 AASSLKSQAATKNLSDACKPLKKRNRASTAA--SSALGFSKSSSPSASLTENEVSDSPGDEPSES 672

  Fly   758 QLHSLDTSIQADVTPIRDLDMRPSTSRVSKFIC-LCQKPSQYYARNAPDSSYCCAIDHIDDQKIG 821
            ...|.|.: |.:|:.......|..|:: .:::| ||:||........|    ||...|     :.
Human   673 PYESADET-QTEVSVSSKKSERGVTAK-KEYVCQLCEKPGSLLLCEGP----CCGAFH-----LA 726

  Fly   822 C------------CNELSSEVHNLLRPSQRVSYMILCDEHK---KRLQSHNCCAGCGIFCTQGKF 871
            |            |:|.:|.:|:          ..:|.|.|   ||.....|          ||
Human   727 CLGLSRRPEGRFTCSECASGIHS----------CFVCKESKTDVKRCVVTQC----------GK- 770

  Fly   872 VLCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLDTPER---TSTVTM 933
                   |:|..|.:::.|:..        |.:|  |..|  :..|..|....|..   :....|
Human   771 -------FYHEACVKKYPLTVF--------ESRG--FRCP--LHSCVSCHASNPSNPRPSKGKMM 816

  Fly   934 KCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARNKGGLSTAVTLSAASSPASKT 998
            :|...||                                   |.:.|....|...|..:|
Human   817 RCVRCPV-----------------------------------AYHSGDACLAAGCSVIAS----- 841

  Fly   999 NGAQRGRAGTSNSNSRHALNSINFAQLIPESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQNDD 1063
                               |||             :...|..:..|:
Human   842 -------------------NSI-------------ICTAHFTARKGK------------------ 856

  Fly  1064 LERVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLC-KGASSPDFVNIVDYELRTAL 1127
                                          .|...:.:::..:| ||.|               |
Human   857 ------------------------------RHHAHVNVSWCFVCSKGGS---------------L 876

  Fly  1128 MCAVMNEKC------DMLNLFLQCGADVAIKGPDGK---------TSLH----IAAQLGNLEATQ 1173
            :|.   |.|      |.||          |:.|||.         ..||    |..:|||
Human   877 LCC---ESCPAAFHPDCLN----------IEMPDGSWFCNDCRAGKKLHFQDIIWVKLGN----- 923

  Fly  1174 LIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIV---------RLASLPQAVFLKLI 1229
                 ||                   |    |.||:.|...|         .:...|
Human   924 -----YR-------------------W----WPAEVCHPKNVPPNIQKMKHEIGEFP-------- 952

  Fly  1230 NIFLFISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIAC 1294
             :|.|.|    :|             .:|:  |...:              ...:|||.    ..
Human   953 -VFFFGS----KD-------------YYWT--HQARV--------------FPYMEGDR----GS 979

  Fly  1295 RHSVTRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPLGLRTFVVCAD 1359
            |:...|        |...:.||..          :|:|.           .||.:.|:
Human   980 RYQGVR--------GIGRVFKNAL----------QEAEA-----------RFREIKLQ------- 1008

  Fly  1360 ASNGREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSC 1424
                ||||..|         |:|.:.     |.:::          :::::...:::|.:. |..
Human  1009 ----REARETQ---------ESERKP-----PPYKH----------IKVNKPYGKVQIYTA-DIS 1044

  Fly  1425 SSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECN-DVCGCNQLSCKNRVVQNGTRTPLQIV 1488
            ...:|.|..       |.|:....|....:..::|||: .||...:. |:|:..........:|:
Human  1045 EIPKCNCKP-------TDENPCGFDSECLNRMLMFECHPQVCPAGEF-CQNQCFTKRQYPETKII 1101

  Fly  1489 ECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRRTDDS--------YYFDLDNGHCIDAN 1545
            :.:  .||||:.|..::.||.||..|.||::...|...|...:        |...:|....|||.
Human  1102 KTD--GKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAG 1164

  Fly  1546 YYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCV 1610
            ..||.:||.||||:||...:: :..:.|.|   :..|:..||.||.|:.|:|        :..|:
Human  1165 PKGNYSRFMNHSCQPNCETLK-WTVNGDTR---VGLFAVCDIPAGTELTFNY--------NLDCL 1217

  Fly  1611 G-----CRCLTTTCKYASQSSSTNASPTNATTAPENETGTLSSTNTEK 1653
            |     |||..:.|     |......|..:||....|.|..:...|.:
Human  1218 GNEKTVCRCGASNC-----SGFLGDRPKTSTTLSSEEKGKKTKKKTRR 1260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412	14/76 (18%)
		EHMT_ZBD	786..933	CDD:411018	33/165 (20%)
		ANKYR	1063..1322	CDD:440430	45/287 (16%)
		ANK repeat	1088..1120	CDD:293786	5/32 (16%)
		ANK repeat	1124..1153	CDD:293786	8/34 (24%)
		ANK repeat	1155..1196	CDD:293786	10/53 (19%)
		ANK repeat	1199..1249	CDD:293786	11/58 (19%)
		ANK repeat	1251..1283	CDD:293786	2/31 (6%)
		ANK repeat	1285..1316	CDD:293786	6/30 (20%)
		SET_EHMT	1391..1622	CDD:380941	61/244 (25%)
NSD2	NP_001427822.1	None