DRSC/TRiP Functional Genomics Resources

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Protein Alignment G9a and KMT2C

DIOPT Version :9

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:XP_005250082.1 Gene:KMT2C / 58508 HGNCID:13726 Length:4983 Species:Homo sapiens


Alignment Length:1909 Identity:345/1909 - (18%)
Similarity:599/1909 - (31%) Gaps:617/1909 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 TSTAEGGTLLNLNLAEDKTLKWRNLANNQFA----SKEKKHKDKEEEERKEARNQEEIEDIKALL 81
            |.|...||:.|.|.......:.....||.|:    .:|:|.:.:|::||:..:..:|::..:|| 
Human  3379 TCTPAPGTVSNANPQSGPPPRVEFDDNNPFSESFQERERKERLREQQERQRIQLMQEVDRQRAL- 3442

  Fly    82 ADVVDAAAVKLEEEEAQNAEKVEPHTK------------CE-------IEEEGRKEMEYDQDVAK 127
                 ...:::|:.....:|.....|.            |:       :::..:.:.:..|.:.:
Human  3443 -----QQRMEMEQHGMVGSEISSSRTSVSQIPFYSSDLPCDFMQPLGPLQQSPQHQQQMGQVLQQ 3502

  Fly   128 QDSEMEKKQNGKATSITVK--MESNERAEKHATEIATTSTERWENESFKTEQQNKKAAEKEEEPI 190
            |:.     |.|...|.:.:  |::|||.:........      ::.|......|..:. |:....
Human  3503 QNI-----QQGSINSPSTQTFMQTNERRQVGPPSFVP------DSPSIPVGSPNFSSV-KQGHGN 3555

  Fly   191 LAATQKLEANAEPLTTTRIEVAVASPLVVSSASVKLAADATNQMRAATSAGAATLADKNVQVSP- 254
            |:.|...::...|..|..:.   |:|.|.:| |:....|:|.....:......:|......:.| 
Human  3556 LSGTSFQQSPVRPSFTPALP---AAPPVANS-SLPCGQDSTITHGHSYPGSTQSLIQLYSDIIPE 3616

  Fly   255 --GGTRRSRRTPRPIDTPTSVTDEHVQVENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQLKSE 317
              |..:|:|:..|..|           .|:.| ..|..::|.::                     
Human  3617 EKGKKKRTRKKKRDDD-----------AESTK-APSTPHSDITA--------------------- 3648

  Fly   318 PDKPSLTALSPEENSAPAPKRGRGRARKIRPDAEVETSEVILPCEDSL--GEKKPGRKRKLPDEP 380
            |..|.::    |..|.||.    ....::...|:.|:.|.:.|...::  |:.....:.|||:..
Human  3649 PPTPGIS----ETTSTPAV----STPSELPQQADQESVEPVGPSTPNMAAGQLCTELENKLPNSD 3705

  Fly   381 IDQQQLSDLVVVKTEQEELG-DAPLGDVKRMRRSVRLGNRLHADGSPWEEVKTEALHPQPSAELS 444
            ..|...:......:|.::|. :.|                     :..||:|.|      .||..
Human  3706 FSQATPNQQTYANSEVDKLSMETP---------------------AKTEEIKLE------KAETE 3743

  Fly   445 FAEVTSEILPLAVLDEKTPPKKRGRKAKTPCVKLESET-SCGLPFANGNKKTNSSGGCEL--QLP 506
            ......|    ..|:|:...|..|.....|....:|.. |.|.|.|.|:      .|.||  .|.
Human  3744 SCPGQEE----PKLEEQNGSKVEGNAVACPVSSAQSPPHSAGAPAAKGD------SGNELLKHLL 3798

  Fly   507 KRSKR----RIKPTPKILENDELRCEFETKHIERMTQWES----AAAVDGDF----ETPTTGGNG 559
            |..|.    ..||...|...|:  |..:.|.:|:....|.    .|.:.|.|    :.|.|.|  
Human  3799 KNKKSSSLLNQKPEGSICSEDD--CTKDNKLVEKQNPAEGLQTLGAQMQGGFGCGNQLPKTDG-- 3859

  Fly   560 SNSSTSRQKSDKSDGSNFEGGPGHP-------------AGTSA---IKKRL-------------- 594
             .|.|.:|:|.::..:..:..|...             :.|..   :|::|              
Human  3860 -GSETKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSTDTFTHLKQQLSLLPLMEPIIGVNF 3923

  Fly   595 ----------FSKSQRDIENYGAAML----------------------AKSKLPPCPD---VEQF 624
                      |:...|.:..:|:|.|                      ..:.|||.|.   .::.
Human  3924 AHFLPYGSGQFNSGNRLLGTFGSATLEGVSDYYSQLIYKQNNLSNPPTPPASLPPTPPPMACQKM 3988

  Fly   625 LNDIKASRINANRS-------------PEERKLN-KKQQRKLAKQKEKHLKHLGLQKNHRDEPSD 675
            .|....:...|.::             |:..:|. :.|...||:...:..|.:.:..:....|.:
Human  3989 ANGFATTEELAGKAGVLVSHEVTKTLGPKPFQLPFRPQDDLLARALAQGPKTVDVPASLPTPPHN 4053

  Fly   676 NDSS----------NTDNEFFPTTR------VQVGK-PSVTL-------RVRNSVTKELPTTA-- 714
            |...          :|.:.|.|::.      |:|.: |.::|       .|.:.:...||:||  
Human  4054 NQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPDLSLVKEEPPEPVPSPIIPILPSTAGK 4118

  Fly   715 TLKSRRNPV-VQAAKL--TRRIGARAAGEVTEAARASVPISTPDAEQLHSLDTSIQADVTPIRDL 776
            :.:||||.: .:...|  ....|....|..:.....::.:....||.:.|:..:. :|:..:|  
Human  4119 SSESRRNDIKTEPGTLYFASPFGPSPNGPRSGLISVAITLHPTAAENISSVVAAF-SDLLHVR-- 4180

  Fly   777 DMRPSTSRVSKFICLCQKPSQYYARNAPDSSYCCAIDHIDDQKIGCCNELSSEVHNLLR------ 835
                             .|:.|...:|||..   ::..:...:|.  ..|....|.|||      
Human  4181 -----------------IPNSYEVSSAPDVP---SMGLVSSHRIN--PGLEYRQHLLLRGPPPGS 4223

  Fly   836 --PSQRVSYMILCDEHKKRLQSHN------------------------------CC------AGC 862
              |.:.||        ..||:..|                              ||      .|.
Human  4224 ANPPRLVS--------SYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCHCKVVILGS 4280

  Fly   863 GIFCTQGKFVLCKQQH------------FFHPDCAQRFILSTSYEKELGDEEDQGV--------- 906
            |:..:.....|..:..            |...:|   |||.:|..:....|..:.:         
Human  4281 GVRKSFKDLTLLNKDSRESTKRVEKDIVFCSNNC---FILYSSTAQAKNSENKESIPSLPQSPMR 4342

  Fly   907 --------KFSSPVLVLKCPHCGLDTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHL--- 960
                    ::|:.:..|.. ||....||:.|.......:.|......:.:.||..|..:..|   
Human  4343 ETPSKAFHQYSNNISTLDV-HCLPQLPEKASPPASPPIAFPPAFEAAQVEAKPDELKVTVKLKPR 4406

  Fly   961 --TQFGTVENANTPGATAR----NKGGLSTAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNS 1019
              ...|..|:........|    .|..:...:.......|..........:.|||          
Human  4407 LRAVHGGFEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTS---------- 4461

  Fly  1020 INFAQLIPESVMNVVLRGHVVSASGRVTAEFTPRD----MYYAVQNDDL-ERVAEILAADFNV-- 1077
                 |.|:.|                     |:|    .:...:.|.| :..|.:|..|.::  
Human  4462 -----LKPDPV---------------------PKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWV 4500

  Fly  1078 -------LTPIREYLNGTCLHL-VAHSGTLQMAYLLLCK-GASSP----DFVNIVDYELRTALMC 1129
                   .|.:.|...|..::: :|....|||..:...| ||:|.    ...||..:.......|
Human  4501 HLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKAQC 4565

  Fly  1130 AVMNEK---CDM----------LNLF------------LQCGADVAIKGPD------GKTSLHIA 1163
            ....:|   |.|          |:.|            ::..|.:..:|..      |....|..
Human  4566 MFFKDKTMLCPMHKPKGIHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTI 4630

  Fly  1164 AQL--GNLEA----TQLIVDSYRTSRNITS---------FLSFIDAQDEGGWTAMVWAAELGHTD 1213
            .||  ..::|    ..|....|..||...|         :|..|:.:| |....::...|.||.|
Human  4631 GQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKD-GRPVFVIRIVEQGHED 4694

  Fly  1214 IVRLASLPQAVFLKLINIFLFISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGAD 1278
            :|.....|:.|:.|::              :|..|....:.:|.....:..|.|...:.:.:   
Human  4695 LVLSDISPKGVWDKIL--------------EPVACVRKKSEMLQLFPAYLKGEDLFGLTVSA--- 4742

  Fly  1279 CNVQNVEGDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQM 1343
              |..:....|...||.:...|..            :|...:||.                    
Human  4743 --VARIAESLPGVEACENYTFRYG------------RNPLMELPL-------------------- 4773

  Fly  1344 RSFRPLGLRTFVVCADASNGREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQI 1408
             :..|.|      ||              |:|..||              .:|.:.:::.::   
Human  4774 -AVNPTG------CA--------------RSEPKMS--------------AHVKRFVLRPHT--- 4800

  Fly  1409 DRRVSQMRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCK 1473
                        |:|.|:.:      |.|:..|.|  |||.::.:            ..:..|.:
Human  4801 ------------LNSTSTSK------SFQSTVTGE--LNAPYSKQ------------FVHSKSSQ 4833

  Fly  1474 NRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRR-------TDDS 1531
            .|.::  |.....:.....:.:|.|:.|..::.|.|.|..|.|.|:....|:|:       ....
Human  4834 YRKMK--TEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGV 4896

  Fly  1532 YYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFD 1596
            |.|.:||.|.|||...|...|:.||||.||.:...|.:|    |..||...|.|.|..|||:|:|
Human  4897 YMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFE----RGHKIIISSSRRIQKGEELCYD 4957

  Fly  1597 YGEKFWRVEHRSCVGCRCLTTTCK 1620
            |...|...:|:  :.|.|....|:
Human  4958 YKFDFEDDQHK--IPCHCGAVNCR 4979

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 ATP-synt_B 150..248 CDD:304375 18/97 (19%)
Ank_2 1056..1152 CDD:289560 25/136 (18%)
ANK 1088..1217 CDD:238125 37/180 (21%)
ANK repeat 1088..1120 CDD:293786 10/37 (27%)
ANK repeat 1124..1153 CDD:293786 7/53 (13%)
Ank_2 1127..1249 CDD:289560 31/167 (19%)
ANK 1155..1306 CDD:238125 32/171 (19%)
ANK repeat 1155..1196 CDD:293786 12/61 (20%)
ANK repeat 1199..1249 CDD:293786 9/49 (18%)
Ank_2 1205..1316 CDD:289560 18/110 (16%)
ANK repeat 1251..1283 CDD:293786 4/31 (13%)
ANK repeat 1285..1316 CDD:293786 4/30 (13%)
PreSET 1357..1466 CDD:128744 17/108 (16%)
SET 1495..1602 CDD:214614 41/113 (36%)
KMT2CXP_005250082.1 ePHD1_KMT2C 248..331 CDD:277166
PHD1_KMT2C_like 344..389 CDD:276984
PHD2_KMT2C 391..436 CDD:277069
PHD3_KMT2C 467..518 CDD:276986
PHD4_KMT2C 953..1009 CDD:277071
PHD5_KMT2C_like 1010..1056 CDD:276988
RanBP2-type Zn finger 1085..1107 CDD:275375
PHD6_KMT2C 1087..1137 CDD:277073
HMG-box 1671..1722 CDD:294061
DUF2962 1709..>1792 CDD:288077
SYCE1 <3198..3287 CDD:291886
ePHD2_KMT2C 4474..4578 CDD:277167 21/103 (20%)
FYRN 4624..4674 CDD:283589 10/49 (20%)
FYRC 4680..4761 CDD:283590 17/99 (17%)
SET <4797..4983 CDD:225491 59/226 (26%)
SET 4844..4965 CDD:214614 42/124 (34%)
PostSET 4967..4983 CDD:214703 4/15 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158040
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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