DRSC/TRiP Functional Genomics Resources

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Protein Alignment G9a and kmt2cb

DIOPT Version :9

Sequence 1:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster
Sequence 2:XP_009296384.1 Gene:kmt2cb / 568162 ZFINID:ZDB-GENE-070705-340 Length:4892 Species:Danio rerio


Alignment Length:1908 Identity:364/1908 - (19%)
Similarity:597/1908 - (31%) Gaps:682/1908 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 TSTAEGGTLLNLNLAEDKTLKWRNLANNQFASKEKKHKDKEEEERKEARNQEEIEDIKALLADVV 85
            |....||...::|.  |.|    |..:..|..:|:|.:.:|::||:..:..:|:|          
Zfish  3355 TQVQAGGESPHVNF--DDT----NPFSEGFQERERKERLREQQERQRMQIIKEVE---------- 3403

  Fly    86 DAAAVK--LEEEEAQNAEKVEPHTKCEIEEEGRKEME-YDQDVAKQDSEMEKKQNGKATSITVKM 147
             ...||  :|:::..|.:        :....|..:|. |:|::.:...:..:.|           
Zfish  3404 -RQHVKHCVEQQQVSNCQ--------DGTMRGLSQMPFYNQELPQDFMQPPRLQ----------- 3448

  Fly   148 ESNERAEKHATEIATTSTERWENESFKTEQQNKKAAEKEEEPILAATQKLEANAEPLTTTRIEVA 212
                              ::.:..:|..:|               .||:......|         
Zfish  3449 ------------------QQIQGPTFPQQQ---------------GTQQGYIGGPP--------- 3471

  Fly   213 VASPLVVSS----------ASVKLAADATNQMRAATSAGAATLADKNVQVSPGGTRRSRRTPRPI 267
              .||:.:.          |...||....|.::|.|.....::.....|..|.|      .|.|:
Zfish  3472 --RPLLGNGPFPQEMGSGFAPQNLAVHGPNLIQAQTRPQRYSVPHMMAQNPPQG------HPFPM 3528

  Fly   268 DTPTSVTDEH-------VQV----------ENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQLK 315
            :.||.:....       :|:          :.|:..|.::..||.|               |:..
Zfish  3529 EGPTPLPPNFPGPGPSLIQLYSNIIPEEKGKKKRNQKKKKDEDCES---------------LRAP 3578

  Fly   316 SEPDKP--SLTA-LSP---EENSAPAPKRGRGRARKIRPDAEVETSEVILPCEDSL-GEKKPGR- 372
            |.|..|  .:|| |:|   :.:|.|.      |...:..|.|.        ||.|. |...||. 
Zfish  3579 STPHTPHSDMTAPLTPCVSDTSSTPT------RNPMVFGDHEF--------CETSQPGSSTPGSM 3629

  Fly   373 --------KRKL--------PDEPIDQQQLSDLVV--VKTEQEELGDAPLGDVKRMRRSVRLGNR 419
                    :|:|        |:..:..:::.|.::  :|.|:.|..|.  ...|.:...:|:|  
Zfish  3630 SSQPHSELERQLSEGSCGGGPESAMGHEEMHDRILSNIKLEKVEANDC--HGHKPIDMEIRIG-- 3690

  Fly   420 LHADGSPWEEVKTEAL--HP--QPSAELSFAEVTSEILPLAVLDEKTPPKKRGRKAKTPCVKLES 480
                   ..:|:.|.:  ||  |..|..|..|..:|:|...:.:::|||.....:.....::.|.
Zfish  3691 -------MVKVEREIMLHHPSSQSPANSSKEEGGNELLKHLLKNKRTPPHALPHQRSEDSLRSEE 3748

  Fly   481 ETSCGLPFANGNKKTNSSGGCE----------LQLPKRSKRRIKPTPKILENDELRCE------- 528
            |.|............:|:|...          |.|..:.|:|.|.|||..:....||:       
Zfish  3749 EGSTESKAFFRQNSMDSTGTFSDSNHQDFPGPLILEDKKKQRNKRTPKSGDRPAPRCKKRKKEED 3813

  Fly   529 ---------------FETKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFE 578
                           .:.:|:..:...|....|:.....|..||             :.||.|..
Zfish  3814 ESQAVYSSTDPMITPLKQQHLSLLPLMEPLVGVNFAHLMPYGGG-------------QLDGENRL 3865

  Fly   579 GGPGHPA---GTSAIKKRLFSKSQRDIENYGAAMLAKSKLPPCPDV---EQFLNDIKASRINANR 637
            .|....|   |.|....:|..| |.::.|   .....:.|||.|..   ::.||....:...|.:
Zfish  3866 SGTFGSASLDGVSDYYSQLIYK-QNNLSN---PPTPPASLPPTPPPVARQKLLNGFATTEELARK 3926

  Fly   638 S---------------PEERKLNKKQQRKLAKQKEKHLKHLGLQKNHRDEPSDN----------D 677
            .               |.|   .|.::..||:...:..|.:.:..:....|.:|          :
Zfish  3927 GGLIAGHDVTKGLLARPLE---FKAEEELLAQALAQGPKTVNVPASLPTPPHNNQEELRGQEHCE 3988

  Fly   678 SSNTDNEFFPTTRVQ--VGK-----PSVTLRVRNSVTKELPTTATLKSRRNPVVQAAKLTRRIGA 735
            ..||.:.|.|::..:  ||.     |.::|     |.:|.|:.|     .:||:....:.|....
Zfish  3989 DRNTPDSFVPSSSPESVVGMEISRYPDLSL-----VKEEPPSPA-----MSPVIPMFPVFRDKDV 4043

  Fly   736 RAAGEVTEAARASVPISTPDAEQLHSLDTSIQADVTPIRDLDMRPSTSRVSKFICLCQKPSQYYA 800
            :.....||      |.|.       ..|:|       .|.:....:|..||  |.:..||:    
Zfish  4044 KLQEVKTE------PSSV-------FFDSS-------FRSVQNGSNTGLVS--IAIMLKPA---- 4082

  Fly   801 RNAPDSSYCCAIDHIDDQKIGCCNELSSEVHNLLR---PSQRVSYMILCDEHKKRLQSHNCCAGC 862
                      |.::|.|        :.:.:.:|:|   ||                 |:...:|.
Zfish  4083 ----------AAENITD--------VVAAIADLIRVKIPS-----------------SYEVSSGP 4112

  Fly   863 GIFCTQGKFVLCKQQHFFHPDC---------------AQRFILSTSYEKELGDEE--DQGVKFSS 910
            |     |.|...|..  ..|.|               .|..:|..::.|.:|.|:  |..|:..|
Zfish  4113 G-----GSFGAIKTS--VDPQCLASALPNGPRALRQAPQHLLLQHNHNKNIGGEQYRDGQVRPGS 4170

  Fly   911 PVLVLK---CPHCGLDTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTS------SH----LTQ 962
                 |   |.||         .|.:..:.:....:.::.|.:.:||.:.      ||    |..
Zfish  4171 -----KQQWCQHC---------KVVVLGKGVRKITKDEEVKPQESRLCSDGGLVFCSHSCLILHS 4221

  Fly   963 FGTVENANTPGATARNKGGLSTAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQLIP 1027
            ..:..|.|     |.||    .:|.|.:.|:.....:..|...:...:|...|.|     |||.|
Zfish  4222 SSSQSNGN-----ADNK----ASVPLLSESALKQSFSKVQHQYSNNMSSLDVHCL-----AQLQP 4272

  Fly  1028 ---------------------ESVMNVVLRGHVVSASGRVTAEFTPR------DMYY-------- 1057
                                 ||....:..||:     :||.:..||      |..:        
Zfish  4273 KPSSPAPYLHMAFAPAKAIKTESKPRSISEGHL-----KVTVKLKPRLHSHLEDKQWHHGKRWKG 4332

  Fly  1058 ---------------AVQN--DDLERVAEILAADFNVLTPIRE--------------------YL 1085
                           |.|:  .:||...:.|.........||:                    .|
Zfish  4333 LRWRKWTIDIAMPKVAPQSSESELEERLKQLTTSLRPCLTIRDQRRCCFCQQIGDGMTDGPARLL 4397

  Fly  1086 N---GTCLHL----------VAHSGTL-------QMAYLLLCK-----GASSP----DFVNIVDY 1121
            |   .|.:||          ...:|.|       |....::|.     ||:|.    ..:||..:
Zfish  4398 NLDLDTWVHLNCALWSSEVYETQAGALINVGLARQRGQTVVCAFCQRLGATSGCHRLRCLNIYHF 4462

  Fly  1122 ELRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLHIAAQLGNLEATQLIVDSYRTSRNIT 1186
            .......|....:|..:.:.....||..|       ..||:..||          ..:...|.: 
Zfish  4463 TCALQAGCTFFKDKTMLCHQHRPRGAGAA-------AGLHVEHQL----------RCFSVFRRV- 4509

  Fly  1187 SFLSFIDAQDEGGWTAMVWAAELGHTDIV------RLASLPQAV---FLKLINIFLFISFLLNQD 1242
                ::...:.....|.|...|.|||..|      .:..||.|:   |.....||          
Zfish  4510 ----YVQRDELRQLAAAVQQPERGHTFRVGSLLFHAMGQLPPALMPTFHSSTAIF---------- 4560

  Fly  1243 ADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIA 1307
             .|..    ..|.|:||..|..        .:....|:|:..||.           ....|.:|.
Zfish  4561 -PPGY----EATRLYWSMRHGQ--------KRCRYVCSVEEHEGR-----------AEFSIRVIE 4601

  Fly  1308 NG-ADLMIKNKAEQLPFD----CIPNEESECGRTVGFNMQMRSFRPLGLRTFVV--CADASNGRE 1365
            .| .||::.:.:.:..::    .:....:|.|....|.:.::.....||....|  .|::..|.|
Zfish  4602 QGYEDLVLTDTSAKGVWEKVLGPVAERRAETGMLRLFPIYLKGEDLFGLTISAVTRIAESLPGVE 4666

  Fly  1366 A----------RPIQVV----------RNELAMSENEDEADSL-MWPDFRYVTQCIIQQNSVQID 1409
            |          .|:.|:          |:||......:....| .||   .:::||  |||....
Zfish  4667 ACSRYRFRYGRNPLLVLPLSMNSSGSARSELQTYPQHERVKILSSWP---RISRCI--QNSTVAA 4726

  Fly  1410 RRVSQMRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCKN 1474
            ...|..:  ..:.|.||...:.......|.|.|.||:                            
Zfish  4727 SASSHSK--HFVHSKSSQYRRLASDWKSNVYLAHSRI---------------------------- 4761

  Fly  1475 RVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRR-------TDDSY 1532
                                :|.|:.|...:.|.|.|..|.|:||....|.||       ...:|
Zfish  4762 --------------------QGLGLFAARAIEKQTMVIEYMGDILRTEVAMRRELLYKAKNRPAY 4806

  Fly  1533 YFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDY 1597
            .|.:|:...|||...|:..|:.||||.||.:...|.:| :.|:.  |...:|| |:.|||:|:||
Zfish  4807 MFCIDSERVIDATNSGSPARYINHSCSPNCVAEVVTFE-RGYKI--IISAACR-IERGEELCYDY 4867

  Fly  1598 GEKFWRVEHRSCVGCRCLTTTCK 1620
              |...|..:|.:.|.|....|:
Zfish  4868 --KLTPVNDQSKIPCHCGAAKCR 4888

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
G9aNP_001259088.1 ATP-synt_B 150..248 CDD:304375 13/107 (12%)
Ank_2 1056..1152 CDD:289560 26/169 (15%)
ANK 1088..1217 CDD:238125 29/160 (18%)
ANK repeat 1088..1120 CDD:293786 12/57 (21%)
ANK repeat 1124..1153 CDD:293786 5/28 (18%)
Ank_2 1127..1249 CDD:289560 24/130 (18%)
ANK 1155..1306 CDD:238125 29/159 (18%)
ANK repeat 1155..1196 CDD:293786 5/40 (13%)
ANK repeat 1199..1249 CDD:293786 14/58 (24%)
Ank_2 1205..1316 CDD:289560 26/120 (22%)
ANK repeat 1251..1283 CDD:293786 7/31 (23%)
ANK repeat 1285..1316 CDD:293786 7/31 (23%)
PreSET 1357..1466 CDD:128744 26/129 (20%)
SET 1495..1602 CDD:214614 41/113 (36%)
kmt2cbXP_009296384.1 PHD_SF 232..319 CDD:304600
PHD1_KMT2C_like 332..377 CDD:276984
PHD2_KMT2C 379..424 CDD:277069
PHD3_KMT2C 459..507 CDD:276986
PHD_SF 947..1003 CDD:304600
PHD5_KMT2C_like 1004..1050 CDD:276988
PHD_SF 1081..1131 CDD:304600
HMG 1691..1744 CDD:197700
DUF4200 3168..3262 CDD:290574
Med15 3255..>3659 CDD:255446 72/418 (17%)
PHD_SF 4379..4483 CDD:304600 16/103 (16%)
FYRN 4536..4586 CDD:283589 13/72 (18%)
FYRC 4594..4673 CDD:283590 15/78 (19%)
SET 4753..4868 CDD:214614 45/168 (27%)
PostSET 4877..4892 CDD:214703 3/12 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593904
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.930

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