Protein Alignment G9a and kmt2cb

DIOPT Version :10

• Sequence 1: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: XP_009296384.1
• Gene: kmt2cb / 568162
• ZFINID: ZDB-GENE-070705-340
• Length: 4892
• Species: Danio rerio
• Alignment Length: 1908
• Identity: 364/1908 - (19%)
• Similarity: 597/1908 - (31%)
• Gaps: 682/1908 - (35%)

  Fly    21 TSTAEGGTLLNLNLAEDKTLKWRNLANNQFASKEKKHKDKEEEERKEARNQEEIEDIKALLADVV 85
            |....||...::|.  |.|    |..:..|..:|:|.:.:|::||:..:..:|:|
Zfish  3355 TQVQAGGESPHVNF--DDT----NPFSEGFQERERKERLREQQERQRMQIIKEVE---------- 3403

  Fly    86 DAAAVK--LEEEEAQNAEKVEPHTKCEIEEEGRKEME-YDQDVAKQDSEMEKKQNGKATSITVKM 147
             ...||  :|:::..|.:        :....|..:|. |:|::.:...:..:.|
Zfish  3404 -RQHVKHCVEQQQVSNCQ--------DGTMRGLSQMPFYNQELPQDFMQPPRLQ----------- 3448

  Fly   148 ESNERAEKHATEIATTSTERWENESFKTEQQNKKAAEKEEEPILAATQKLEANAEPLTTTRIEVA 212
                              ::.:..:|..:|               .||:......|
Zfish  3449 ------------------QQIQGPTFPQQQ---------------GTQQGYIGGPP--------- 3471

  Fly   213 VASPLVVSS----------ASVKLAADATNQMRAATSAGAATLADKNVQVSPGGTRRSRRTPRPI 267
              .||:.:.          |...||....|.::|.|.....::.....|..|.|      .|.|:
Zfish  3472 --RPLLGNGPFPQEMGSGFAPQNLAVHGPNLIQAQTRPQRYSVPHMMAQNPPQG------HPFPM 3528

  Fly   268 DTPTSVTDEH-------VQV----------ENKKFGKSEQYTDCSSHLERFTLDDNTAIVRLQLK 315
            :.||.:....       :|:          :.|:..|.::..||.|               |:..
Zfish  3529 EGPTPLPPNFPGPGPSLIQLYSNIIPEEKGKKKRNQKKKKDEDCES---------------LRAP 3578

  Fly   316 SEPDKP--SLTA-LSP---EENSAPAPKRGRGRARKIRPDAEVETSEVILPCEDSL-GEKKPGR- 372
            |.|..|  .:|| |:|   :.:|.|.      |...:..|.|.        ||.|. |...||.
Zfish  3579 STPHTPHSDMTAPLTPCVSDTSSTPT------RNPMVFGDHEF--------CETSQPGSSTPGSM 3629

  Fly   373 --------KRKL--------PDEPIDQQQLSDLVV--VKTEQEELGDAPLGDVKRMRRSVRLGNR 419
                    :|:|        |:..:..:::.|.::  :|.|:.|..|.  ...|.:...:|:|
Zfish  3630 SSQPHSELERQLSEGSCGGGPESAMGHEEMHDRILSNIKLEKVEANDC--HGHKPIDMEIRIG-- 3690

  Fly   420 LHADGSPWEEVKTEAL--HP--QPSAELSFAEVTSEILPLAVLDEKTPPKKRGRKAKTPCVKLES 480
                   ..:|:.|.:  ||  |..|..|..|..:|:|...:.:::|||.....:.....::.|.
Zfish  3691 -------MVKVEREIMLHHPSSQSPANSSKEEGGNELLKHLLKNKRTPPHALPHQRSEDSLRSEE 3748

  Fly   481 ETSCGLPFANGNKKTNSSGGCE----------LQLPKRSKRRIKPTPKILENDELRCE------- 528
            |.|............:|:|...          |.|..:.|:|.|.|||..:....||:
Zfish  3749 EGSTESKAFFRQNSMDSTGTFSDSNHQDFPGPLILEDKKKQRNKRTPKSGDRPAPRCKKRKKEED 3813

  Fly   529 ---------------FETKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFE 578
                           .:.:|:..:...|....|:.....|..||             :.||.|..
Zfish  3814 ESQAVYSSTDPMITPLKQQHLSLLPLMEPLVGVNFAHLMPYGGG-------------QLDGENRL 3865

  Fly   579 GGPGHPA---GTSAIKKRLFSKSQRDIENYGAAMLAKSKLPPCPDV---EQFLNDIKASRINANR 637
            .|....|   |.|....:|..| |.::.|   .....:.|||.|..   ::.||....:...|.:
Zfish  3866 SGTFGSASLDGVSDYYSQLIYK-QNNLSN---PPTPPASLPPTPPPVARQKLLNGFATTEELARK 3926

  Fly   638 S---------------PEERKLNKKQQRKLAKQKEKHLKHLGLQKNHRDEPSDN----------D 677
            .               |.|   .|.::..||:...:..|.:.:..:....|.:|          :
Zfish  3927 GGLIAGHDVTKGLLARPLE---FKAEEELLAQALAQGPKTVNVPASLPTPPHNNQEELRGQEHCE 3988

  Fly   678 SSNTDNEFFPTTRVQ--VGK-----PSVTLRVRNSVTKELPTTATLKSRRNPVVQAAKLTRRIGA 735
            ..||.:.|.|::..:  ||.     |.::|     |.:|.|:.|     .:||:....:.|....
Zfish  3989 DRNTPDSFVPSSSPESVVGMEISRYPDLSL-----VKEEPPSPA-----MSPVIPMFPVFRDKDV 4043

  Fly   736 RAAGEVTEAARASVPISTPDAEQLHSLDTSIQADVTPIRDLDMRPSTSRVSKFICLCQKPSQYYA 800
            :.....||      |.|.       ..|:|       .|.:....:|..||  |.:..||:
Zfish  4044 KLQEVKTE------PSSV-------FFDSS-------FRSVQNGSNTGLVS--IAIMLKPA---- 4082

  Fly   801 RNAPDSSYCCAIDHIDDQKIGCCNELSSEVHNLLR---PSQRVSYMILCDEHKKRLQSHNCCAGC 862
                      |.::|.|        :.:.:.:|:|   ||                 |:...:|.
Zfish  4083 ----------AAENITD--------VVAAIADLIRVKIPS-----------------SYEVSSGP 4112

  Fly   863 GIFCTQGKFVLCKQQHFFHPDC---------------AQRFILSTSYEKELGDEE--DQGVKFSS 910
            |     |.|...|..  ..|.|               .|..:|..::.|.:|.|:  |..|:..|
Zfish  4113 G-----GSFGAIKTS--VDPQCLASALPNGPRALRQAPQHLLLQHNHNKNIGGEQYRDGQVRPGS 4170

  Fly   911 PVLVLK---CPHCGLDTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTS------SH----LTQ 962
                 |   |.||         .|.:..:.:....:.::.|.:.:||.:.      ||    |..
Zfish  4171 -----KQQWCQHC---------KVVVLGKGVRKITKDEEVKPQESRLCSDGGLVFCSHSCLILHS 4221

  Fly   963 FGTVENANTPGATARNKGGLSTAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQLIP 1027
            ..:..|.|     |.||    .:|.|.:.|:.....:..|...:...:|...|.|     |||.|
Zfish  4222 SSSQSNGN-----ADNK----ASVPLLSESALKQSFSKVQHQYSNNMSSLDVHCL-----AQLQP 4272

  Fly  1028 ---------------------ESVMNVVLRGHVVSASGRVTAEFTPR------DMYY-------- 1057
                                 ||....:..||:     :||.:..||      |..:
Zfish  4273 KPSSPAPYLHMAFAPAKAIKTESKPRSISEGHL-----KVTVKLKPRLHSHLEDKQWHHGKRWKG 4332

  Fly  1058 ---------------AVQN--DDLERVAEILAADFNVLTPIRE--------------------YL 1085
                           |.|:  .:||...:.|.........||:                    .|
Zfish  4333 LRWRKWTIDIAMPKVAPQSSESELEERLKQLTTSLRPCLTIRDQRRCCFCQQIGDGMTDGPARLL 4397

  Fly  1086 N---GTCLHL----------VAHSGTL-------QMAYLLLCK-----GASSP----DFVNIVDY 1121
            |   .|.:||          ...:|.|       |....::|.     ||:|.    ..:||..:
Zfish  4398 NLDLDTWVHLNCALWSSEVYETQAGALINVGLARQRGQTVVCAFCQRLGATSGCHRLRCLNIYHF 4462

  Fly  1122 ELRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLHIAAQLGNLEATQLIVDSYRTSRNIT 1186
            .......|....:|..:.:.....||..|       ..||:..||          ..:...|.:
Zfish  4463 TCALQAGCTFFKDKTMLCHQHRPRGAGAA-------AGLHVEHQL----------RCFSVFRRV- 4509

  Fly  1187 SFLSFIDAQDEGGWTAMVWAAELGHTDIV------RLASLPQAV---FLKLINIFLFISFLLNQD 1242
                ::...:.....|.|...|.|||..|      .:..||.|:   |.....||
Zfish  4510 ----YVQRDELRQLAAAVQQPERGHTFRVGSLLFHAMGQLPPALMPTFHSSTAIF---------- 4560

  Fly  1243 ADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIA 1307
             .|..    ..|.|:||..|..        .:....|:|:..||.           ....|.:|.
Zfish  4561 -PPGY----EATRLYWSMRHGQ--------KRCRYVCSVEEHEGR-----------AEFSIRVIE 4601

  Fly  1308 NG-ADLMIKNKAEQLPFD----CIPNEESECGRTVGFNMQMRSFRPLGLRTFVV--CADASNGRE 1365
            .| .||::.:.:.:..::    .:....:|.|....|.:.::.....||....|  .|::..|.|
Zfish  4602 QGYEDLVLTDTSAKGVWEKVLGPVAERRAETGMLRLFPIYLKGEDLFGLTISAVTRIAESLPGVE 4666

  Fly  1366 A----------RPIQVV----------RNELAMSENEDEADSL-MWPDFRYVTQCIIQQNSVQID 1409
            |          .|:.|:          |:||......:....| .||   .:::||  |||....
Zfish  4667 ACSRYRFRYGRNPLLVLPLSMNSSGSARSELQTYPQHERVKILSSWP---RISRCI--QNSTVAA 4726

  Fly  1410 RRVSQMRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCKN 1474
            ...|..:  ..:.|.||...:.......|.|.|.||:
Zfish  4727 SASSHSK--HFVHSKSSQYRRLASDWKSNVYLAHSRI---------------------------- 4761

  Fly  1475 RVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRR-------TDDSY 1532
                                :|.|:.|...:.|.|.|..|.|:||....|.||       ...:|
Zfish  4762 --------------------QGLGLFAARAIEKQTMVIEYMGDILRTEVAMRRELLYKAKNRPAY 4806

  Fly  1533 YFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDY 1597
            .|.:|:...|||...|:..|:.||||.||.:...|.:| :.|:.  |...:|| |:.|||:|:||
Zfish  4807 MFCIDSERVIDATNSGSPARYINHSCSPNCVAEVVTFE-RGYKI--IISAACR-IERGEELCYDY 4867

  Fly  1598 GEKFWRVEHRSCVGCRCLTTTCK 1620
              |...|..:|.:.|.|....|:
Zfish  4868 --KLTPVNDQSKIPCHCGAAKCR 4888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412	13/122 (11%)
		EHMT_ZBD	786..933	CDD:411018	32/169 (19%)
		ANKYR	1063..1322	CDD:440430	57/317 (18%)
		ANK repeat	1088..1120	CDD:293786	12/57 (21%)
		ANK repeat	1124..1153	CDD:293786	5/28 (18%)
		ANK repeat	1155..1196	CDD:293786	5/40 (13%)
		ANK repeat	1199..1249	CDD:293786	14/58 (24%)
		ANK repeat	1251..1283	CDD:293786	7/31 (23%)
		ANK repeat	1285..1316	CDD:293786	7/31 (23%)
		SET_EHMT	1391..1622	CDD:380941	61/237 (26%)
kmt2cb	XP_009296384.1	PHD_SF	232..319	CDD:473978
		PHD1_KMT2C_like	332..377	CDD:276984
		PHD2_KMT2C	379..424	CDD:277069
		PHD3_KMT2C	459..507	CDD:276986
		PHD_SF	947..1003	CDD:473978
		PHD5_KMT2C_like	1004..1050	CDD:276988
		PHD_SF	1081..1131	CDD:473978
		HMG-box_KMT2C	1672..1752	CDD:438835
		PHA03247	<1871..2385	CDD:223021
		GBP_C	<3168..3268	CDD:460721
		PHA03247	<3273..3602	CDD:223021	58/347 (17%)
		PHD_SF	4379..4483	CDD:473978	16/103 (16%)
		FYRN	4535..4586	CDD:461787	13/73 (18%)
		FYRC	4595..4676	CDD:461788	15/80 (19%)
		SET	4739..4891	CDD:394802	53/204 (26%)